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Design Therapeutics

95 hedge funds and large institutions have $260M invested in Design Therapeutics in 2025 Q3 according to their latest regulatory filings, with 14 funds opening new positions, 17 increasing their positions, 38 reducing their positions, and 11 closing their positions.

New
Increased
Maintained
Reduced
Closed

800% more call options, than puts

Call options by funds: $9K | Put options by funds: $1K

123% more capital invested

Capital invested by funds: $116M → $260M (+$143M)

100% more funds holding in top 10

Funds holding in top 10: 12 (+1)

27% more first-time investments, than exits

New positions opened: 14 | Existing positions closed: 11

3% more funds holding

Funds holding: 9295 (+3)

0.26% less ownership

Funds ownership: 60.83%60.57% (-0.26%)

55% less repeat investments, than reductions

Existing positions increased: 17 | Existing positions reduced: 38

Holders
95
Holders Change
+3
Holders Change %
+3.26%
% of All Funds
1.25%
Holding in Top 10
2
Holding in Top 10 Change
+1
Holding in Top 10 Change %
+100%
% of All Funds
0.03%
New
14
Increased
17
Reduced
38
Closed
11
Calls
$9K
Puts
$1K
Net Calls
+$8K
Net Calls Change
-$36K
Name Holding Trade Value Shares
Change
Change in
Stake
SOCM
1
SR One Capital Management
Pennsylvania
$49.1M
LGM
2
Logos Global Management
California
$27.5M -$2.82M -562,627 -13%
Point72 Asset Management
3
Point72 Asset Management
Connecticut
$25.2M +$7.68M +1,533,334 +85%
BlackRock
4
BlackRock
New York
$15.4M -$1.76M -351,355 -15%
FLSM
5
Frazier Life Sciences Management
California
$14.7M
TCM
6
Tang Capital Management
California
$13.4M
BBA
7
Baker Bros. Advisors
New York
$12.9M
AC
8
Almitas Capital
California
$11.5M
Vanguard Group
9
Vanguard Group
Pennsylvania
$10.9M -$140K -27,873 -2%
DCM
10
Driehaus Capital Management
Illinois
$8.1M
KCM
11
Kynam Capital Management
New Jersey
$7.75M
Fidelity Investments
12
Fidelity Investments
Massachusetts
$5.58M -$1.05M -210,349 -22%
Geode Capital Management
13
Geode Capital Management
Massachusetts
$5.24M -$493K -98,395 -12%
State Street
14
State Street
Massachusetts
$4.78M -$425K -84,815 -12%
Acadian Asset Management
15
Acadian Asset Management
Massachusetts
$4.65M -$49.4K -9,859 -2%
WP
16
Woodline Partners
California
$4.61M -$826K -164,825 -21%
MB
17
MPM BioImpact
Massachusetts
$4.18M
Citadel Advisors
18
Citadel Advisors
Florida
$4.17M -$1.44M -286,773 -34%
RCM
19
RA Capital Management
Massachusetts
$3.58M +$2.38M +475,699 New
D.E. Shaw & Co
20
D.E. Shaw & Co
New York
$2.81M -$87K -17,372 -4%
Northern Trust
21
Northern Trust
Illinois
$2.23M -$331K -65,989 -18%
Dimensional Fund Advisors
22
Dimensional Fund Advisors
Texas
$2.11M -$168K -33,546 -11%
Renaissance Technologies
23
Renaissance Technologies
New York
$2.07M +$32.6K +6,500 +2%
Goldman Sachs
24
Goldman Sachs
New York
$1.97M +$110K +21,986 +9%
Charles Schwab
25
Charles Schwab
California
$1.87M -$15.1K -3,015 -1%

DSGN Hedge Fund Activity: Q3 2025 in Review

95 of the 7,621 institutional investors tracked by Wall St. Rank reported a position in Design Therapeutics (DSGN) for Q3 2025, worth a combined $260M — up 123% from $116M a quarter earlier.

Buyers outnumbered sellers: 14 funds opened new DSGN positions and 11 closed out — a net gain of 3 holders — while 17 added to existing stakes and 38 trimmed.

The largest buyer was Point72 Asset Management, adding an estimated $7.68M. The largest seller was Logos Global Management, cutting an estimated $2.82M.

  • 95 institutional investors held Design Therapeutics (DSGN) as of Q3 2025, up from 92 in Q2 2025.
  • Funds reported $260M of Design Therapeutics stock for Q3 2025, up 123% quarter-over-quarter.
  • 14 funds opened new Design Therapeutics positions in Q3 2025 and 11 closed out, a net change of +3 holders.
  • The largest Design Therapeutics buyer in Q3 2025 was Point72 Asset Management, an estimated $7.68M added.
  • The largest Design Therapeutics seller in Q3 2025 was Logos Global Management, an estimated $2.82M sold.

Based on aggregated 13F filings for Q3 2025.