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Design Therapeutics

92 hedge funds and large institutions have $116M invested in Design Therapeutics in 2025 Q2 according to their latest regulatory filings, with 5 funds opening new positions, 35 increasing their positions, 34 reducing their positions, and 11 closing their positions.

New
Increased
Maintained
Reduced
Closed

3% more repeat investments, than reductions

Existing positions increased: 35 | Existing positions reduced: 34

0.12% more ownership

Funds ownership: 60.71%60.83% (+0.12%)

6% less funds holding

Funds holding: 9892 (-6)

13% less capital invested

Capital invested by funds: $133M → $116M (-$16.6M)

50% less funds holding in top 10

Funds holding in top 10: 21 (-1)

55% less first-time investments, than exits

New positions opened: 5 | Existing positions closed: 11

Holders
92
Holders Change
-6
Holders Change %
-6.12%
% of All Funds
1.21%
Holding in Top 10
1
Holding in Top 10 Change
-1
Holding in Top 10 Change %
-50%
% of All Funds
0.01%
New
5
Increased
35
Reduced
34
Closed
11
Calls
$44K
Puts
Net Calls
+$44K
Net Calls Change
+$46K
Name Holding Trade Value Shares
Change
Change in
Stake
SOCM
1
SR One Capital Management
Pennsylvania
$22M
LGM
2
Logos Global Management
California
$14.2M
BlackRock
3
BlackRock
New York
$8.07M -$315K -84,220 -3%
FLSM
4
Frazier Life Sciences Management
California
$6.58M
Point72 Asset Management
5
Point72 Asset Management
Connecticut
$6.09M -$39.8K -10,640 -0.6%
TCM
6
Tang Capital Management
California
$6M +$374K +100,000 +6%
BBA
7
Baker Bros. Advisors
New York
$5.77M -$115K -30,843 -2%
AC
8
Almitas Capital
California
$5.16M +$290K +77,539 +5%
Vanguard Group
9
Vanguard Group
Pennsylvania
$4.96M +$165K +44,107 +3%
DCM
10
Driehaus Capital Management
Illinois
$3.63M +$609K +162,837 +18%
KCM
11
Kynam Capital Management
New Jersey
$3.47M +$470K +125,562 +14%
Fidelity Investments
12
Fidelity Investments
Massachusetts
$3.21M +$11.8K +3,148 +0.3%
Citadel Advisors
13
Citadel Advisors
Florida
$2.83M -$459K -122,667 -13%
Geode Capital Management
14
Geode Capital Management
Massachusetts
$2.68M +$69.3K +18,511 +2%
WP
15
Woodline Partners
California
$2.62M +$493K +131,843 +20%
State Street
16
State Street
Massachusetts
$2.42M +$19.2K +5,138 +0.7%
Acadian Asset Management
17
Acadian Asset Management
Massachusetts
$2.11M -$13.5K -3,605 -0.6%
MB
18
MPM BioImpact
Massachusetts
$1.87M -$29K -7,756 -1%
D.E. Shaw & Co
19
D.E. Shaw & Co
New York
$1.32M -$17.2K -4,603 -1%
Northern Trust
20
Northern Trust
Illinois
$1.22M -$41.7K -11,135 -3%
Dimensional Fund Advisors
21
Dimensional Fund Advisors
Texas
$1.06M +$92.7K +24,761 +9%
Renaissance Technologies
22
Renaissance Technologies
New York
$902K +$10.5K +2,800 +1%
Charles Schwab
23
Charles Schwab
California
$846K -$27.8K -7,426 -3%
Goldman Sachs
24
Goldman Sachs
New York
$807K -$99.4K -26,557 -10%
Morgan Stanley
25
Morgan Stanley
New York
$720K -$128K -34,328 -14%

DSGN Hedge Fund Activity: Q2 2025 in Review

92 of the 7,596 institutional investors tracked by Wall St. Rank reported a position in Design Therapeutics (DSGN) for Q2 2025, worth a combined $116M — down 13% from $133M a quarter earlier.

Sellers outnumbered buyers: 11 funds closed out of DSGN and 5 opened new positions — a net loss of 6 holders — while 34 trimmed existing stakes and 35 added.

The largest buyer was Driehaus Capital Management, adding an estimated $609K. The largest seller was Wellington Management Group, exiting entirely with an estimated $546K sold.

  • 92 institutional investors held Design Therapeutics (DSGN) as of Q2 2025, down from 98 in Q1 2025.
  • Funds reported $116M of Design Therapeutics stock for Q2 2025, down 13% quarter-over-quarter.
  • 5 funds opened new Design Therapeutics positions in Q2 2025 and 11 closed out, a net change of -6 holders.
  • The largest Design Therapeutics buyer in Q2 2025 was Driehaus Capital Management, an estimated $609K added.
  • The largest Design Therapeutics seller in Q2 2025 was Wellington Management Group, an estimated $546K sold.

Based on aggregated 13F filings for Q2 2025.