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Design Therapeutics
DSGN

98 hedge funds and large institutions have $133M invested in Design Therapeutics in 2025 Q1 according to their latest regulatory filings, with 13 funds opening new positions, 28 increasing their positions, 37 reducing their positions, and 10 closing their positions.

New
Increased
Maintained
Reduced
Closed

30% more first-time investments, than exits

New positions opened: 13 | Existing positions closed: 10

3% more funds holding

Funds holding: 95 → 98 (+3)

1.61% more ownership

Funds ownership: 59.1% → 60.71% (+1.6%)

0% more funds holding in top 10

Funds holding in top 10: 2 → 2 (0)

12% less call options, than puts

Call options by funds: $15K | Put options by funds: $17K

24% less repeat investments, than reductions

Existing positions increased: 28 | Existing positions reduced: 37

36% less capital invested

Capital invested by funds: $206M → $133M (-$73.4M)

Holders
98
Holders Change
+3
Holders Change %
+3.16%
% of All Funds
1.31%
Holding in Top 10
2
Holding in Top 10 Change
–
Holding in Top 10 Change %
–
% of All Funds
0.03%
New
13
Increased
28
Reduced
37
Closed
10
Calls
$15K
Puts
$17K
Net Calls
-$2K
Net Calls Change
-$14K

Top Buyers

Rank Fund Capital Flow
1
KCM
Kynam Capital Management
New Jersey
+$4.31M
2
WP
Woodline Partners
California
+$3.08M
3
TCM
Tang Capital Management
California
+$954K
4
Wellington Management Group
Wellington Management Group
Massachusetts
+$675K
5
DCM
Driehaus Capital Management
Illinois
+$655K

Top Sellers

Rank Fund Capital Flow
1
EC
EcoR1 Capital
California
-$2.63M
2
Walleye Capital
Walleye Capital
New York
-$871K
3
D.E. Shaw & Co
D.E. Shaw & Co
New York
-$559K
4
BlackRock
BlackRock
New York
-$475K
5
Morgan Stanley
Morgan Stanley
New York
-$469K
Name Holding Trade Value Shares
Change 		Change in
Stake
AIP
76
Ameritas Investment Partners
Nebraska
$9.92K – – –
Legal & General Group
77
Legal & General Group
United Kingdom
$9.91K – – –
California State Teachers Retirement System (CalSTRS)
78
California State Teachers Retirement System (CalSTRS)
California
$8.78K – – –
Zurich Cantonal Bank
79
Zurich Cantonal Bank
Switzerland
$8.36K +$10.3K +2,165 New
Mirae Asset Global Investments
80
Mirae Asset Global Investments
South Korea
$7.98K +$38 +8 +0.4%
New York State Common Retirement Fund
81
New York State Common Retirement Fund
New York
$7.82K – – –
GFM
82
GF Fund Management
China
$5.59K +$1.24K +260 +22%
AB
83
Amalgamated Bank
New York
$5K – – –
CA
84
Clearstead Advisors
Ohio
$2.35K – – –
PWMG
85
Private Wealth Management Group
New Jersey
$2.15K – – –
SCM
86
Sterling Capital Management
North Carolina
$2.09K -$2.21K -463 -46%
CCM
87
Coldstream Capital Management
Washington
$2.07K +$2.55K +535 New
Simplex Trading
88
Simplex Trading
Illinois
$1K -$23.4K -4,905 -95%
Daiwa Securities Group
89
Daiwa Securities Group
Japan
$1K +$1.67K +350 New
MPWT
90
MassMutual Private Wealth & Trust
Connecticut
$923 – – –
GI
91
GAMMA Investing
California
$880 -$4.02K -842 -79%
PS
92
Principal Securities
Iowa
$457 – – –
Osaic Holdings
93
Osaic Holdings
Arizona
$189 -$115 -24 -33%
EWA
94
EverSource Wealth Advisors
Alabama
$120 +$148 +31 New
BIG
95
Brooklyn Investment Group
New York
$74 +$91 +19 New
FFA
96
Farther Finance Advisors
California
$68 – – –
EC
97
EcoR1 Capital
California
– -$2.63M -426,683 Closed
Walleye Capital
98
Walleye Capital
New York
– -$871K -141,127 Closed
XT
99
XTX Topco
Cayman Islands
– -$299K -48,424 Closed
Squarepoint
100
Squarepoint
New York
– -$297K -48,186 Closed
1 2 3
4
5

DSGN Hedge Fund Activity: Q1 2025 in Review

98 of the 7,459 institutional investors tracked by Wall St. Rank reported a position in Design Therapeutics (DSGN) for Q1 2025, worth a combined $133M — down 36% from $206M a quarter earlier.

Buyers outnumbered sellers: 13 funds opened new DSGN positions and 10 closed out — a net gain of 3 holders — while 28 added to existing stakes and 37 trimmed.

The largest buyer was Kynam Capital Management, opening a new position worth an estimated $4.31M. The largest seller was EcoR1 Capital, exiting entirely with an estimated $2.63M sold.

  • 98 institutional investors held Design Therapeutics (DSGN) as of Q1 2025, up from 95 in Q4 2024.
  • Funds reported $133M of Design Therapeutics stock for Q1 2025, down 36% quarter-over-quarter.
  • 13 funds opened new Design Therapeutics positions in Q1 2025 and 10 closed out, a net change of +3 holders.
  • The largest Design Therapeutics buyer in Q1 2025 was Kynam Capital Management, an estimated $4.31M added.
  • The largest Design Therapeutics seller in Q1 2025 was EcoR1 Capital, an estimated $2.63M sold.

Based on aggregated 13F filings for Q1 2025.