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Design Therapeutics
DSGN

117 hedge funds and large institutions have $358M invested in Design Therapeutics in 2025 Q4 according to their latest regulatory filings, with 31 funds opening new positions, 39 increasing their positions, 28 reducing their positions, and 8 closing their positions.

New
Increased
Maintained
Reduced
Closed

4,504% more call options, than puts

Call options by funds: $4.7M | Put options by funds: $102K

288% more first-time investments, than exits

New positions opened: 31 | Existing positions closed: 8

39% more repeat investments, than reductions

Existing positions increased: 39 | Existing positions reduced: 28

38% more capital invested

Capital invested by funds: $260M → $358M (+$98.1M)

23% more funds holding

Funds holding: 95 → 117 (+22)

6.4% more ownership

Funds ownership: 60.57% → 66.97% (+6.4%)

0% more funds holding in top 10

Funds holding in top 10: 2 → 2 (0)

Holders
117
Holders Change
+22
Holders Change %
+23.16%
% of All Funds
1.42%
Holding in Top 10
2
Holding in Top 10 Change
–
Holding in Top 10 Change %
–
% of All Funds
0.02%
New
31
Increased
39
Reduced
28
Closed
8
Calls
$4.7M
Puts
$102K
Net Calls
+$4.59M
Net Calls Change
+$4.59M

Top Buyers

Rank Fund Capital Flow
1
Point72 Asset Management
Point72 Asset Management
Connecticut
+$15.9M
2
VC
Vivo Capital
California
+$12.6M
3
RCM
RA Capital Management
Massachusetts
+$7.72M
4
Morgan Stanley
Morgan Stanley
New York
+$4.12M
5
BBA
Baker Bros. Advisors
New York
+$4.07M

Top Sellers

Rank Fund Capital Flow
1
TCM
Tang Capital Management
California
-$13.4M
2
FLSM
Frazier Life Sciences Management
California
-$11.2M
3
LGM
Logos Global Management
California
-$9.04M
4
MB
MPM BioImpact
Massachusetts
-$4.18M
5
KCM
Kynam Capital Management
New Jersey
-$1.92M
Name Holding Trade Value Shares
Change 		Change in
Stake
Charles Schwab
26
Charles Schwab
California
$2.22M -$86.7K -11,071 -4%
Jane Street
27
Jane Street
New York
$2.12M +$851K +108,679 +92%
Marshall Wace
28
Marshall Wace
United Kingdom
$2.12M +$1.77M +225,528 New
EC
29
Elmind Capital
New York
$1.95M +$1.63M +207,900 New
Jacobs Levy Equity Management
30
Jacobs Levy Equity Management
New Jersey
$1.83M +$1.52M +194,611 New
AG
31
Algert Global
California
$1.76M +$1.47M +187,769 New
Millennium Management
32
Millennium Management
New York
$1.7M +$877K +112,043 +163%
Ameriprise
33
Ameriprise
Minnesota
$1.49M +$1.24M +158,383 New
ACP
34
Acuta Capital Partners
California
$1.42M +$1.18M +150,906 New
N
35
Nuveen
North Carolina
$1.17M -$60.8K -7,768 -6%
Raymond James Financial
36
Raymond James Financial
Florida
$1.03M +$859K +109,763 New
DP
37
Diadema Partners
New Jersey
$941K +$786K +100,320 New
TI
38
Trexquant Investment
Connecticut
$938K +$783K +99,967 New
BNP Paribas Financial Markets
39
BNP Paribas Financial Markets
France
$889K +$702K +89,695 +1,747%
Barclays
40
Barclays
United Kingdom
$817K -$8.74K -1,116 -1%
Bank of New York Mellon
41
Bank of New York Mellon
New York
$797K -$19.6K -2,500 -3%
EI
42
EAM Investors
California
$741K +$618K +78,949 New
BCM
43
Bridgeway Capital Management
Texas
$736K -$859K -109,700 -58%
LCM
44
Lynx1 Capital Management
Puerto Rico
$652K +$27.9K +3,562 +5%
PWM
45
Palumbo Wealth Management
New York
$651K +$135K +17,296 +33%
Susquehanna International Group
46
Susquehanna International Group
Pennsylvania
$580K +$375K +47,829 +341%
American Century Companies
47
American Century Companies
Missouri
$542K +$54.4K +6,946 +14%
Canada Pension Plan Investment Board
48
Canada Pension Plan Investment Board
Ontario, Canada
$512K +$428K +54,600 New
Corient Private Wealth
49
Corient Private Wealth
Florida
$506K +$422K +53,930 New
SEI Investments
50
SEI Investments
Pennsylvania
$495K +$413K +52,730 New
1
2
3 4 5

DSGN Hedge Fund Activity: Q4 2025 in Review

117 of the 8,223 institutional investors tracked by Wall St. Rank reported a position in Design Therapeutics (DSGN) for Q4 2025, worth a combined $358M — up 38% from $260M a quarter earlier.

Buyers outnumbered sellers: 31 funds opened new DSGN positions and 8 closed out — a net gain of 23 holders — while 39 added to existing stakes and 28 trimmed.

The largest buyer was Point72 Asset Management, adding an estimated $15.9M. The largest seller was Tang Capital Management, exiting entirely with an estimated $13.4M sold.

  • 117 institutional investors held Design Therapeutics (DSGN) as of Q4 2025, up from 95 in Q3 2025.
  • Funds reported $358M of Design Therapeutics stock for Q4 2025, up 38% quarter-over-quarter.
  • 31 funds opened new Design Therapeutics positions in Q4 2025 and 8 closed out, a net change of +23 holders.
  • The largest Design Therapeutics buyer in Q4 2025 was Point72 Asset Management, an estimated $15.9M added.
  • The largest Design Therapeutics seller in Q4 2025 was Tang Capital Management, an estimated $13.4M sold.

Based on aggregated 13F filings for Q4 2025.