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Design Therapeutics
DSGN

98 hedge funds and large institutions have $133M invested in Design Therapeutics in 2025 Q1 according to their latest regulatory filings, with 13 funds opening new positions, 28 increasing their positions, 37 reducing their positions, and 10 closing their positions.

New
Increased
Maintained
Reduced
Closed

30% more first-time investments, than exits

New positions opened: 13 | Existing positions closed: 10

3% more funds holding

Funds holding: 95 → 98 (+3)

1.61% more ownership

Funds ownership: 59.1% → 60.71% (+1.6%)

0% more funds holding in top 10

Funds holding in top 10: 2 → 2 (0)

12% less call options, than puts

Call options by funds: $15K | Put options by funds: $17K

24% less repeat investments, than reductions

Existing positions increased: 28 | Existing positions reduced: 37

36% less capital invested

Capital invested by funds: $206M → $133M (-$73.4M)

Holders
98
Holders Change
+3
Holders Change %
+3.16%
% of All Funds
1.31%
Holding in Top 10
2
Holding in Top 10 Change
–
Holding in Top 10 Change %
–
% of All Funds
0.03%
New
13
Increased
28
Reduced
37
Closed
10
Calls
$15K
Puts
$17K
Net Calls
-$2K
Net Calls Change
-$14K

Top Buyers

Rank Fund Capital Flow
1
KCM
Kynam Capital Management
New Jersey
+$4.31M
2
WP
Woodline Partners
California
+$3.08M
3
TCM
Tang Capital Management
California
+$954K
4
Wellington Management Group
Wellington Management Group
Massachusetts
+$675K
5
DCM
Driehaus Capital Management
Illinois
+$655K

Top Sellers

Rank Fund Capital Flow
1
EC
EcoR1 Capital
California
-$2.63M
2
Walleye Capital
Walleye Capital
New York
-$871K
3
D.E. Shaw & Co
D.E. Shaw & Co
New York
-$559K
4
BlackRock
BlackRock
New York
-$475K
5
Morgan Stanley
Morgan Stanley
New York
-$469K
Name Holding Trade Value Shares
Change 		Change in
Stake
N
26
Nuveen
North Carolina
$568K -$51.4K -10,776 -7%
Two Sigma Advisers
27
Two Sigma Advisers
New York
$566K -$416K -87,200 -37%
Wellington Management Group
28
Wellington Management Group
Massachusetts
$546K +$675K +141,519 New
Two Sigma Investments
29
Two Sigma Investments
New York
$497K -$359K -75,184 -37%
BCM
30
Bridgeway Capital Management
Texas
$439K -$69.7K -14,600 -11%
Bank of New York Mellon
31
Bank of New York Mellon
New York
$368K – – –
Millennium Management
32
Millennium Management
New York
$340K +$420K +87,988 New
Barclays
33
Barclays
United Kingdom
$324K -$93.3K -19,565 -19%
GCP
34
GSA Capital Partners
United Kingdom
$278K -$220K -46,179 -39%
LCM
35
Lynx1 Capital Management
Puerto Rico
$255K +$315K +65,954 New
PWM
36
Palumbo Wealth Management
New York
$225K +$17.1K +3,582 +7%
Prudential Financial
37
Prudential Financial
New Jersey
$218K +$429 +90 +0.2%
BNP Paribas Financial Markets
38
BNP Paribas Financial Markets
France
$204K +$60K +12,583 +31%
RhumbLine Advisers
39
RhumbLine Advisers
Massachusetts
$179K -$31.3K -6,563 -12%
American Century Companies
40
American Century Companies
Missouri
$171K +$25.3K +5,300 +14%
Susquehanna International Group
41
Susquehanna International Group
Pennsylvania
$167K +$28.2K +5,911 +16%
AllianceBernstein
42
AllianceBernstein
Tennessee
$162K – – –
Assenagon Asset Management
43
Assenagon Asset Management
Luxembourg
$143K -$94K -19,700 -35%
UBS Group
44
UBS Group
Switzerland
$127K -$161K -33,768 -51%
AQR Capital Management
45
AQR Capital Management
Connecticut
$123K +$8.99K +1,885 +6%
Deutsche Bank
46
Deutsche Bank
Germany
$109K +$167 +35 +0.1%
Corient Private Wealth
47
Corient Private Wealth
Florida
$104K – – –
Citigroup
48
Citigroup
New York
$88.3K -$7.62K -1,597 -7%
SO
49
STRS Ohio
Ohio
$87.2K -$47.7K -10,000 -31%
Bank of America
50
Bank of America
North Carolina
$85.6K -$62K -12,994 -37%
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DSGN Hedge Fund Activity: Q1 2025 in Review

98 of the 7,459 institutional investors tracked by Wall St. Rank reported a position in Design Therapeutics (DSGN) for Q1 2025, worth a combined $133M — down 36% from $206M a quarter earlier.

Buyers outnumbered sellers: 13 funds opened new DSGN positions and 10 closed out — a net gain of 3 holders — while 28 added to existing stakes and 37 trimmed.

The largest buyer was Kynam Capital Management, opening a new position worth an estimated $4.31M. The largest seller was EcoR1 Capital, exiting entirely with an estimated $2.63M sold.

  • 98 institutional investors held Design Therapeutics (DSGN) as of Q1 2025, up from 95 in Q4 2024.
  • Funds reported $133M of Design Therapeutics stock for Q1 2025, down 36% quarter-over-quarter.
  • 13 funds opened new Design Therapeutics positions in Q1 2025 and 10 closed out, a net change of +3 holders.
  • The largest Design Therapeutics buyer in Q1 2025 was Kynam Capital Management, an estimated $4.31M added.
  • The largest Design Therapeutics seller in Q1 2025 was EcoR1 Capital, an estimated $2.63M sold.

Based on aggregated 13F filings for Q1 2025.