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DFTX

Definium Therapeutics
DFTX

208 hedge funds and large institutions have $909M invested in Definium Therapeutics in 2025 Q4 according to their latest regulatory filings, with 50 funds opening new positions, 92 increasing their positions, 31 reducing their positions, and 30 closing their positions.

New
Increased
Maintained
Reduced
Closed

197% more repeat investments, than reductions

Existing positions increased: 92 | Existing positions reduced: 31

117% more call options, than puts

Call options by funds: $23.4M | Put options by funds: $10.8M

94% more capital invested

Capital invested by funds: $469M → $909M (+$440M)

67% more funds holding in top 10

Funds holding in top 10: 3 → 5 (+2)

67% more first-time investments, than exits

New positions opened: 50 | Existing positions closed: 30

16.66% more ownership

Funds ownership: 52.23% → 68.89% (+17%)

7% more funds holding

Funds holding: 195 → 208 (+13)

Holders
208
Holders Change
+13
Holders Change %
+6.67%
% of All Funds
2.53%
Holding in Top 10
5
Holding in Top 10 Change
+2
Holding in Top 10 Change %
+66.67%
% of All Funds
0.06%
New
50
Increased
92
Reduced
31
Closed
30
Calls
$23.4M
Puts
$10.8M
Net Calls
+$12.6M
Net Calls Change
+$2.18M

Top Buyers

Rank Fund Capital Flow
1
ACA
Avoro Capital Advisors
New York
+$61.9M
2
DCM
Driehaus Capital Management
Illinois
+$42.4M
3
Janus Henderson Group
Janus Henderson Group
United Kingdom
+$29.5M
4
BlackRock
BlackRock
New York
+$28.9M
5
Balyasny Asset Management
Balyasny Asset Management
Illinois
+$16.2M

Top Sellers

Rank Fund Capital Flow
1
CC
Commodore Capital
New York
-$15.2M
2
Blackstone Inc
Blackstone Inc
New York
-$8.87M
3
TCM
Tang Capital Management
California
-$7.08M
4
ABG
Ally Bridge Group
New York
-$4.26M
5
Citadel Advisors
Citadel Advisors
Florida
-$1.6M
Name Holding Trade Value Shares
Change 		Change in
Stake
SWP
176
Strategic Wealth Partners
Ohio
$2.22K +$2.05K +166 New
CIBC Private Wealth Group
177
CIBC Private Wealth Group
Georgia
$2.02K – – –
AF
178
Allworth Financial
California
$1.98K +$780 +63 +74%
NA
179
NewEdge Advisors
Louisiana
$1.87K -$25 -2 -1%
Optiver Holding
180
Optiver Holding
Netherlands
$1.65K -$1.18K -95 -44%
HWM
181
HighMark Wealth Management
Minnesota
$1.34K – – –
NS
182
NBC Securities
Alabama
$1.34K – – –
SS
183
SBI Securities
Japan
$1.22K -$173 -14 -13%
RAM
184
Reflection Asset Management
South Carolina
$898 +$817 +66 New
Federated Hermes
185
Federated Hermes
Pennsylvania
$897 +$829 +67 New
AWM
186
Activest Wealth Management
Florida
$884 – – –
KBFS
187
Kohmann Bosshard Financial Services
Ohio
$884 +$817 +66 New
MASM
188
MH & Associates Securities Management
California
$884 +$817 +66 New
MCM
189
MAI Capital Management
Ohio
$791 +$606 +49 +490%
TCM
190
Tradewinds Capital Management
Washington
$710 – – –
SS
191
Sunbelt Securities
Texas
$589 – – –
PMFA
192
Plante Moran Financial Advisors
Michigan
$482 – – –
FGAM
193
Financial Gravity Asset Management
Texas
$469 -$161 -13 -27%
CAM
194
Chesapeake Asset Management
New York
$441 – – –
RF
195
Robbins Farley
New Hampshire
$375 – – –
PWPS
196
Pinnacle Wealth Planning Services
Ohio
$335 +$309 +25 New
RIAS
197
Rachor Investment Advisory Services
Michigan
$335 +$309 +25 New
EP
198
Essential Partners
California
$281 +$210 +17 +425%
CIAM
199
Caitong International Asset Management
Hong Kong
$201 +$186 +15 New
CB
200
CNB Bank
Pennsylvania
$134 – – –
6 7
8
9 10

DFTX Hedge Fund Activity: Q4 2025 in Review

208 of the 8,223 institutional investors tracked by Wall St. Rank reported a position in Definium Therapeutics (DFTX) for Q4 2025, worth a combined $909M — up 94% from $469M a quarter earlier.

Buyers outnumbered sellers: 50 funds opened new DFTX positions and 30 closed out — a net gain of 20 holders — while 92 added to existing stakes and 31 trimmed.

The largest buyer was Avoro Capital Advisors, opening a new position worth an estimated $61.9M. The largest seller was Commodore Capital, cutting an estimated $15.2M.

  • 208 institutional investors held Definium Therapeutics (DFTX) as of Q4 2025, up from 195 in Q3 2025.
  • Funds reported $909M of Definium Therapeutics stock for Q4 2025, up 94% quarter-over-quarter.
  • 50 funds opened new Definium Therapeutics positions in Q4 2025 and 30 closed out, a net change of +20 holders.
  • The largest Definium Therapeutics buyer in Q4 2025 was Avoro Capital Advisors, an estimated $61.9M added.
  • The largest Definium Therapeutics seller in Q4 2025 was Commodore Capital, an estimated $15.2M sold.

Based on aggregated 13F filings for Q4 2025.