DFTX

Definium Therapeutics

206 hedge funds and large institutions have $909M invested in Definium Therapeutics in 2025 Q4 according to their latest regulatory filings, with 49 funds opening new positions, 91 increasing their positions, 31 reducing their positions, and 30 closing their positions.

New
Increased
Maintained
Reduced
Closed

more repeat investments, than reductions

Existing positions increased: | Existing positions reduced:

more call options, than puts

Call options by funds: $ | Put options by funds: $

more capital invested

Capital invested by funds: $ → $

more funds holding in top 10

Funds holding in top 10:

63% more first-time investments, than exits

New positions opened: 49 | Existing positions closed: 30

16.66% more ownership

Funds ownership: 52.23%68.89% (+17%)

6% more funds holding

Funds holding: 194206 (+12)

Holders
206
Holders Change
Holders Change %
% of All Funds
Holding in Top 10
5
Holding in Top 10 Change
Holding in Top 10 Change %
% of All Funds
New
Increased
Reduced
Closed
Calls
$23.4M
Puts
$10.8M
Net Calls
Net Calls Change

Top Buyers

1 +$61.9M
2 +$42.4M
3 +$29.5M
4
BlackRock
BlackRock
New York
+$28.9M
5
Balyasny Asset Management
Balyasny Asset Management
Illinois
+$16.2M

Top Sellers

1 -$15.2M
2 -$8.87M
3 -$7.08M
4
ABG
Ally Bridge Group
New York
-$4.26M
5
Citadel Advisors
Citadel Advisors
Florida
-$1.6M
Name Holding Trade Value Shares
Change
Change in
Stake
Teacher Retirement System of Texas
126
Teacher Retirement System of Texas
Texas
$158K
BHCM
127
Brevan Howard Capital Management
Jersey
$149K
DWM
128
Diversify Wealth Management
Utah
$149K
TPWM
129
Twelve Points Wealth Management
Massachusetts
$147K
XT
130
XTX Topco
Cayman Islands
$147K
SA
131
Sanctuary Advisors
Indiana
$144K
FDCDDQ
132
Federation des caisses Desjardins du Quebec
Quebec, Canada
$142K
Osaic Holdings
133
Osaic Holdings
Arizona
$141K
S
134
SharpePoint
Arizona
$136K
KWMG
135
King Wealth Management Group
Florida
$134K
Russell Investments Group
136
Russell Investments Group
United Kingdom
$119K
FHA
137
Flagship Harbor Advisors
Massachusetts
$117K
AIP
138
Ameritas Investment Partners
Nebraska
$102K
HCM
139
Hollencrest Capital Management
California
$101K
PNC Financial Services Group
140
PNC Financial Services Group
Pennsylvania
$94.9K
NSIM
141
North Star Investment Management
Illinois
$89.7K
Carson Wealth (CWM LLC)
142
Carson Wealth (CWM LLC)
Nebraska
$72K
TRCT
143
Tower Research Capital (TRC)
New York
$58K
Walleye Trading
144
Walleye Trading
New York
$57K
SIS
145
Sound Income Strategies
Florida
$55.5K
SCM
146
Sterling Capital Management
North Carolina
$52.4K
Fifth Third Bancorp
147
Fifth Third Bancorp
Ohio
$44.2K
AB
148
Amalgamated Bank
New York
$40K
CA
149
Crewe Advisors
Utah
$26.8K
GFM
150
GF Fund Management
China
$25.9K