|
1
|
DekaBank Deutsche Girozentrale
Frankfurt,
Germany
|
$759K
|
–
|
–
|
–
|
|
|
2
|
|
–
|
-$94.3M
|
-5,994,276
|
Closed
|
|
|
3
|
Armistice Capital
New York
|
–
|
-$92.8M
|
-5,900,000
|
Closed
|
|
|
4
|
Redmile Group
San Francisco,
California
|
–
|
-$83.3M
|
-5,296,643
|
Closed
|
|
|
5
|
Deerfield Management
New York
|
–
|
-$80.7M
|
-5,127,270
|
Closed
|
|
|
6
|
Vanguard Group
Malvern,
Pennsylvania
|
–
|
-$71.8M
|
-4,565,044
|
Closed
|
|
|
7
|
State Street
Boston,
Massachusetts
|
–
|
-$48.7M
|
-3,098,806
|
Closed
|
|
|
8
|
|
–
|
-$30.9M
|
-1,962,841
|
Closed
|
|
|
9
|
Dimensional Fund Advisors
Austin,
Texas
|
–
|
-$25.3M
|
-1,606,132
|
Closed
|
|
|
10
|
|
–
|
-$24.2M
|
-1,539,826
|
Closed
|
|
|
11
|
Polar Capital Holdings
London,
United Kingdom
|
–
|
-$23.6M
|
-1,500,000
|
Closed
|
|
|
12
|
Frazier Life Sciences Management
Palo Alto,
California
|
–
|
-$22.9M
|
-1,455,837
|
Closed
|
|
|
13
|
Nuveen
Charlotte,
North Carolina
|
–
|
-$22.4M
|
-1,425,282
|
Closed
|
|
|
14
|
Geode Capital Management
Boston,
Massachusetts
|
–
|
-$19.7M
|
-1,254,317
|
Closed
|
|
|
15
|
Emerald Advisers
Leola,
Pennsylvania
|
–
|
-$16.4M
|
-1,044,871
|
Closed
|
|
|
16
|
Emerald Mutual Fund Advisers Trust
Leola,
Pennsylvania
|
–
|
-$13M
|
-824,402
|
Closed
|
|
|
17
|
Jefferies Financial Group
New York
|
–
|
-$12.9M
|
-822,515
|
Closed
|
|
|
18
|
Assenagon Asset Management
Senningerberg,
Luxembourg
|
–
|
-$12.7M
|
-809,923
|
Closed
|
|
|
19
|
Millennium Management
New York
|
–
|
-$12.5M
|
-797,100
|
Closed
|
|
|
20
|
Parkman Healthcare Partners
Stamford,
Connecticut
|
–
|
-$11.5M
|
-729,230
|
Closed
|
|
|
21
|
Braidwell
Stamford,
Connecticut
|
–
|
-$9.59M
|
-609,643
|
Closed
|
|
|
22
|
Tang Capital Management
San Diego,
California
|
–
|
-$9.44M
|
-600,000
|
Closed
|
|
|
23
|
New Leaf Venture Partners
New York
|
–
|
-$9.08M
|
-576,975
|
Closed
|
|
|
24
|
Charles Schwab
San Francisco,
California
|
–
|
-$8.36M
|
-531,475
|
Closed
|
|
|
25
|
Renaissance Technologies
New York
|
–
|
-$8.34M
|
-530,200
|
Closed
|
|
