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Castle Biosciences

180 hedge funds and large institutions have $516M invested in Castle Biosciences in 2025 Q1 according to their latest regulatory filings, with 29 funds opening new positions, 77 increasing their positions, 54 reducing their positions, and 44 closing their positions.

New
Increased
Maintained
Reduced
Closed

79% more call options, than puts

Call options by funds: $200K | Put options by funds: $112K

43% more repeat investments, than reductions

Existing positions increased: 77 | Existing positions reduced: 54

0% more funds holding in top 10

Funds holding in top 10: 22 (0)

3.89% less ownership

Funds ownership: 94.63%90.74% (-3.9%)

9% less funds holding

Funds holding: 197180 (-17)

27% less capital invested

Capital invested by funds: $706M → $516M (-$190M)

34% less first-time investments, than exits

New positions opened: 29 | Existing positions closed: 44

Holders
180
Holders Change
-17
Holders Change %
-8.63%
% of All Funds
2.41%
Holding in Top 10
2
Holding in Top 10 Change
Holding in Top 10 Change %
% of All Funds
0.03%
New
29
Increased
77
Reduced
54
Closed
44
Calls
$200K
Puts
$112K
Net Calls
+$88K
Net Calls Change
-$2.62M
Name Holding Trade Value Shares
Change
Change in
Stake
Millennium Management
26
Millennium Management
New York
$5.1M -$7.28M -294,060 -54%
TI
27
Trexquant Investment
Connecticut
$4.98M +$1.12M +45,420 +22%
Charles Schwab
28
Charles Schwab
California
$4.85M -$411K -16,608 -6%
CSS
29
Cubist Systematic Strategies
Connecticut
$4.76M +$1.49M +60,161 +34%
Point72 Asset Management
30
Point72 Asset Management
Connecticut
$4.73M -$7.7M -310,886 -57%
Allspring Global Investments
31
Allspring Global Investments
North Carolina
$4.36M +$5.14M +207,761 +2,071%
Morgan Stanley
32
Morgan Stanley
New York
$4.24M -$2.35M -94,884 -31%
ACM
33
Advisors Capital Management
New Jersey
$4.04M +$563K +22,752 +13%
SAM
34
Silvercrest Asset Management
New York
$3.98M -$28.4K -1,148 -0.6%
D.E. Shaw & Co
35
D.E. Shaw & Co
New York
$3.79M +$2.44M +98,614 +109%
Connor, Clark & Lunn Investment Management (CC&L)
36
Connor, Clark & Lunn Investment Management (CC&L)
British Columbia, Canada
$3.54M +$202K +8,176 +5%
Goldman Sachs
37
Goldman Sachs
New York
$3.51M -$6.37M -257,425 -59%
Tudor Investment Corp
38
Tudor Investment Corp
Connecticut
$3.43M +$2.51M +101,306 +145%
SCM
39
Shelton Capital Management
Colorado
$3.28M
New York State Common Retirement Fund
40
New York State Common Retirement Fund
New York
$3.27M -$642K -25,942 -14%
AG
41
Algert Global
California
$2.89M -$128K -5,180 -3%
Two Sigma Investments
42
Two Sigma Investments
New York
$2.8M +$3.46M +139,785 New
AQR Capital Management
43
AQR Capital Management
Connecticut
$2.74M +$2.87M +115,907 +549%
Franklin Resources
44
Franklin Resources
California
$1.98M +$630K +25,449 +35%
Squarepoint
45
Squarepoint
New York
$1.95M +$1.98M +80,043 +462%
BC
46
Birchview Capital
Vermont
$1.77M +$258K +10,404 +13%
Bank of New York Mellon
47
Bank of New York Mellon
New York
$1.68M -$10.3K -418 -0.5%
BCI
48
Brinker Capital Investments
Pennsylvania
$1.57M +$250K +10,093 +15%
OPS
49
Orion Portfolio Solutions
Nebraska
$1.57M +$250K +10,093 +15%
ECM
50
ExodusPoint Capital Management
New York
$1.55M +$1.64M +66,079 +575%

CSTL Hedge Fund Activity: Q1 2025 in Review

180 of the 7,458 institutional investors tracked by Wall St. Rank reported a position in Castle Biosciences (CSTL) for Q1 2025, worth a combined $516M — down 27% from $706M a quarter earlier.

Sellers outnumbered buyers: 44 funds closed out of CSTL and 29 opened new positions — a net loss of 15 holders — while 54 trimmed existing stakes and 77 added.

The largest buyer was Schroder Investment Management Group, opening a new position worth an estimated $14.8M. The largest seller was Wasatch Advisors, cutting an estimated $19.7M.

  • 180 institutional investors held Castle Biosciences (CSTL) as of Q1 2025, down from 197 in Q4 2024.
  • Funds reported $516M of Castle Biosciences stock for Q1 2025, down 27% quarter-over-quarter.
  • 29 funds opened new Castle Biosciences positions in Q1 2025 and 44 closed out, a net change of -15 holders.
  • The largest Castle Biosciences buyer in Q1 2025 was Schroder Investment Management Group, an estimated $14.8M added.
  • The largest Castle Biosciences seller in Q1 2025 was Wasatch Advisors, an estimated $19.7M sold.

Based on aggregated 13F filings for Q1 2025.