CSTL icon

Castle Biosciences

21.42 USD
-1.33
5.85%
At close Updated Sep 12, 4:00 PM EDT
Pre-market
After hours
21.42
0.00
0%
1 day
-5.85%
5 days
-9.39%
1 month
10.75%
3 months
13.82%
6 months
9.12%
Year to date
-23.61%
1 year
-30.18%
5 years
-56.78%
10 years
0.09%
 

About: Castle Biosciences Inc is a molecular diagnostics company. The group provides test solutions for the diagnosis and treatment of dermatologic cancers, Barrett's esophagus (BE), and uveal melanoma. The product portfolio of the company includes DecisionDx-Melanoma, a risk stratification gene expression profile (GEP) test; DecisionDx-SCC, a risk stratification test for cutaneous squamous cell carcinoma; MyPath Melanoma, a diagnostic GEP test for use in patients with difficult-to-diagnose melanocytic lesions; and TissueCypher, a test to predict future development of progression of high-grade dysplasia and/or esophageal cancer. It also provides DecisionDx-UM, a risk stratification GEP test. The company also offers its products to the skin cancer and gastroenterology markets.

Employees: 798

0
Funds holding %
of 7,462 funds
Analysts bullish %

Fund manager confidence

Based on 2025 Q2 regulatory disclosures by fund managers ($100M+ AUM)

450% more call options, than puts

Call options by funds: $22K | Put options by funds: $4K

59% more repeat investments, than reductions

Existing positions increased: 70 | Existing positions reduced: 44

1.17% more ownership

Funds ownership: 90.74% [Q1] → 91.91% (+1.17%) [Q2]

5% more capital invested

Capital invested by funds: $516M [Q1] → $542M (+$25.5M) [Q2]

16% less funds holding

Funds holding: 180 [Q1] → 152 (-28) [Q2]

62% less first-time investments, than exits

New positions opened: 16 | Existing positions closed: 42

100% less funds holding in top 10

Funds holding in top 10: 2 [Q1] → 0 (-2) [Q2]

Research analyst outlook

1 Wall Street Analyst provided 1 year price targets over the past 3 months

Low target
$37
73% upside
Avg. target
$37
73% upside
High target
$37
73% upside

1 analyst rating

positive
100%
neutral
0%
negative
0%
Canaccord Genuity
Kyle Mikson
$37
Buy
Maintained
9 Sep 2025

Financial journalist opinion

Based on 4 articles about CSTL published over the past 30 days

Neutral
GlobeNewsWire
4 days ago
New Data at American Foregut Society's 2025 Annual Meeting Demonstrates TissueCypher® Can Detect High-Risk Barrett's Esophagus Patients Not Identified by Pathology to Support Improved Care Decisions
FRIENDSWOOD, Texas, Sept. 09, 2025 (GLOBE NEWSWIRE) -- Castle Biosciences, Inc. (Nasdaq: CSTL), a company improving health through innovative tests that guide patient care, today announced that new data demonstrating the personalized risk stratification provided by its TissueCypher Barrett's Esophagus test will be shared via a podium presentation at the American Foregut Society's (AFS) 2025 Annual Meeting, taking place Sept.
New Data at American Foregut Society's 2025 Annual Meeting Demonstrates TissueCypher® Can Detect High-Risk Barrett's Esophagus Patients Not Identified by Pathology to Support Improved Care Decisions
Positive
Seeking Alpha
11 days ago
Castle Biosciences: Strong Margins, Solid Balance Sheet, And Big Upside Potential
Castle Biosciences effectively translates complex diagnostics into a scalable, high-margin business, with strong clinical demand and a robust balance sheet supporting long-term growth. The investment thesis centers on margin expansion and payer coverage; current valuation does not reflect the company's profit potential or future margin upside. Key risks include reimbursement uncertainty for DecisionDx-SCC and insurer behavior, but Castle's cash reserves and diversified test portfolio provide a cushion.
Castle Biosciences: Strong Margins, Solid Balance Sheet, And Big Upside Potential
Neutral
GlobeNewsWire
19 days ago
New Evidence Published Supporting Use of DecisionDx®-SCC Test in Guiding and Improving Treatment Pathway Decisions in NCCN High-Risk Cutaneous Squamous Cell Carcinoma
New validation study shows DecisionDx-SCC significantly outperforms current staging systems in predicting risk of local recurrence and metastasis for NCCN high-risk patients Clinician survey confirms test results align with treatment decision-making thresholds for adjuvant radiation therapy and surveillance imaging FRIENDSWOOD, Texas, Aug. 25, 2025 (GLOBE NEWSWIRE) -- Castle Biosciences, Inc. (Nasdaq: CSTL), a company improving health through innovative tests that guide patient care, today announced the publication of two new studies related to its DecisionDx-SCC test, adding to its validated uses for patients with high-risk cutaneous squamous cell carcinoma (SCC).1,2 DecisionDx-SCC is a gene expression profile test (40-GEP) designed to use a patient's tumor biology to predict individual risk of metastasis as well as response to adjuvant radiation therapy (ART). The first study represents an expanded clinical use milestone, demonstrating that DecisionDx-SCC predicts local recurrence in patients classified as high-risk by National Comprehensive Cancer Network (NCCN) guidelines who have undergone Mohs resection, thereby adding a third use to the test's existing capabilities.
New Evidence Published Supporting Use of DecisionDx®-SCC Test in Guiding and Improving Treatment Pathway Decisions in NCCN High-Risk Cutaneous Squamous Cell Carcinoma
Neutral
GlobeNewsWire
23 days ago
Castle Biosciences to Participate in Upcoming Investor Conferences
FRIENDSWOOD, Texas, Aug. 21, 2025 (GLOBE NEWSWIRE) -- Castle Biosciences, Inc. (Nasdaq: CSTL), a company improving health through innovative tests that guide patient care, today announced that its executive management is scheduled to present a company overview at Baird's 2025 Global Healthcare Conference on Wednesday, Sept. 10, 2025, at 10:15 a.m.
Castle Biosciences to Participate in Upcoming Investor Conferences
Neutral
Seeking Alpha
1 month ago
Castle Biosciences, Inc. (CSTL) Q2 2025 Earnings Call Transcript
Castle Biosciences, Inc. (NASDAQ:CSTL ) Q2 2025 Earnings Conference Call August 4, 2025 4:30 PM ET Company Participants Camilla Zuckero - Vice President of Investor Relations & Corporate Affairs Derek J. Maetzold - Founder, CEO, President & Director Frank Stokes - CFO & Treasurer Conference Call Participants Catherine Walden Ramsey Schulte - Robert W.
Castle Biosciences, Inc. (CSTL) Q2 2025 Earnings Call Transcript
Positive
The Motley Fool
1 month ago
Castle (CSTL) Q2 Revenue Tops Estimates
Castle (CSTL) Q2 Revenue Tops Estimates
Castle (CSTL) Q2 Revenue Tops Estimates
Positive
Zacks Investment Research
1 month ago
Castle Biosciences, Inc. (CSTL) Q2 Earnings and Revenues Surpass Estimates
Castle Biosciences, Inc. (CSTL) came out with quarterly earnings of $0.15 per share, beating the Zacks Consensus Estimate of a loss of $0.51 per share. This compares to earnings of $0.31 per share a year ago.
Castle Biosciences, Inc. (CSTL) Q2 Earnings and Revenues Surpass Estimates
Neutral
GlobeNewsWire
1 month ago
Castle Biosciences Reports Second Quarter 2025 Results
Delivered Q2 2025 revenue of $86 million Q 2 2025 total test reports for our core revenue drivers (DecisionDx ® -Melanoma, TissueCypher ® ) increased 33% over Q 2 2024 Raising full-year 2025 revenue guidance range to $310-320 million from $287-297 million Conference call and webcast today at 4:30 p.m. ET FRIENDSWOOD, Texas, Aug. 04, 2025 (GLOBE NEWSWIRE) -- Castle Biosciences, Inc. (Nasdaq: CSTL), a company improving health through innovative tests that guide patient care, today announced its financial results for the second quarter and six months ended June 30, 2025.
Castle Biosciences Reports Second Quarter 2025 Results
Negative
Zacks Investment Research
1 month ago
New Strong Sell Stocks for August 1st
CRSP, CSTL and SIGI have been added to the Zacks Rank #5 (Strong Sell) List on August 1, 2025.
New Strong Sell Stocks for August 1st
Neutral
GlobeNewsWire
1 month ago
Castle Biosciences to Present at the Canaccord Genuity 45th Annual Growth Conference
Castle Biosciences' executive management will present a company overview at the Canaccord Genuity 45th Annual Growth Conference Aug. 12, 2025 at 12:30pm ET
Castle Biosciences to Present at the Canaccord Genuity 45th Annual Growth Conference
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