Two Sigma Investments
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Two Sigma Investments’s Castle Biosciences CSTL Stock Holding History

Two Sigma Investments’s Portfolio CSTL Stock Details CSTL Fund Activity
Bought
Maintained
Sold
Quarter Market Value Status Shares Change in
Stake 		Trade Value Portfolio Weight Portfolio Position
2026
Q1 		$6.11M Buy
248,840
+164,774
+196% +$5.4M ﹤0.01% 1803
2025
Q4 		$3.27M Buy
84,066
+58,366
+227% +$1.88M ﹤0.01% 2079
2025
Q3 		$585K Sell
25,700
-2,541
-9% -$51.6K ﹤0.01% 2911
2025
Q2 		$577K Sell
28,241
-111,544
-80% -$2.07M ﹤0.01% 2522
2025
Q1 		$2.8M Buy
+139,785
New +$3.46M 0.01% 1519
2024
Q4 		– Sell
-9,800
Closed -$279K – 3253
2024
Q3 		$279K Sell
9,800
-7,000
-42% -$178K ﹤0.01% 2698
2024
Q2 		$366K Buy
16,800
+100
+0.6% +$2.23K ﹤0.01% 2513
2024
Q1 		$370K Sell
16,700
-600
-3% -$13.1K ﹤0.01% 2465
2023
Q4 		$373K Buy
17,300
+4,500
+35% +$79.2K ﹤0.01% 2600
2023
Q3 		$216K Sell
12,800
-19,100
-60% -$334K ﹤0.01% 2612
2023
Q2 		$438K Buy
31,900
+9,276
+41% +$188K ﹤0.01% 2384
2023
Q1 		$514K Sell
22,624
-31,321
-58% -$765K ﹤0.01% 2188
2022
Q4 		$1.27M Sell
53,945
-67,603
-56% -$1.57M ﹤0.01% 1575
2022
Q3 		$3.17M Sell
121,548
-27,881
-19% -$782K 0.01% 953
2022
Q2 		$3.28M Buy
+149,429
New +$3.47M 0.01% 946
2022
Q1 		– Sell
-135,367
Closed -$5.8M – 3009
2021
Q4 		$5.8M Buy
135,367
+62,401
+86% +$3.26M 0.01% 1107
2021
Q3 		$4.85M Buy
72,966
+30,028
+70% +$2.11M 0.01% 1251
2021
Q2 		$3.15M Sell
42,938
-49,286
-53% -$3.26M 0.01% 1511
2021
Q1 		$6.31M Buy
92,224
+22,409
+32% +$1.68M 0.02% 923
2020
Q4 		$4.69M Buy
69,815
+65,615
+1,562% +$3.56M 0.01% 977
2020
Q3 		$216K Sell
4,200
-25,852
-86% -$1.15M ﹤0.01% 2778
2020
Q2 		$1.13M Buy
+30,052
New +$1.03M 0.01% 1465

Other funds holding CSTL

BlackRock
BlackRock New York $5.72T AUM 30.48% 1-Year Est. Return
RI
RTW Investments New York $10B AUM 135.35% 1-Year Est. Return
Principal Financial Group
Principal Financial Group Des Moines, Iowa $187B AUM 18.48% 1-Year Est. Return
PCM
Portolan Capital Management Boston, Massachusetts $1.88B AUM 115.74% 1-Year Est. Return
VCM
Vanguard Capital Management Malvern, Pennsylvania $4.04T AUM
Dimensional Fund Advisors
Dimensional Fund Advisors Austin, Texas $481B AUM 30.42% 1-Year Est. Return
SPPAM
Summit Partners Public Asset Management Boston, Massachusetts $3.72B AUM 162.29% 1-Year Est. Return
VPM
Vanguard Portfolio Management Malvern, Pennsylvania $1.91T AUM
Allianz Asset Management
Allianz Asset Management Munich, Germany $95.4B AUM 38.74% 1-Year Est. Return
State Street
State Street Boston, Massachusetts $2.9T AUM 29.55% 1-Year Est. Return

Two Sigma Investments's CSTL Position: Q1 2026 in Review

Two Sigma Investments increased its Castle Biosciences (CSTL) stake by 196% in Q1 2026, buying an estimated $5.4M and bringing the position to 248,840 shares worth $6.11M. The position accounts for ﹤0.01% of the portfolio, ranked #1803.

Two Sigma Investments first reported a position in CSTL in Q2 2020 and has held it in 22 quarters since. The position peaked at $6.31M in Q1 2021. 186 funds tracked by Wall St. Rank hold CSTL as of Q1 2026.

  • Two Sigma Investments held 248,840 shares of Castle Biosciences worth $6.11M as of Q1 2026.
  • Two Sigma Investments bought 164,774 Castle Biosciences shares in Q1 2026, an estimated $5.4M.
  • Castle Biosciences made up ﹤0.01% of Two Sigma Investments's portfolio in Q1 2026, its #1803 holding.
  • Two Sigma Investments first reported a position in Castle Biosciences in Q2 2020 and has held it in 22 quarters since.
  • Two Sigma Investments's Castle Biosciences position peaked at $6.31M in Q1 2021.
  • 186 funds tracked by Wall St. Rank held Castle Biosciences as of Q1 2026.

Based on Two Sigma Investments's 13F filing for Q1 2026, filed 15 May 2026.