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Crinetics Pharmaceuticals

225 hedge funds and large institutions have $4.49B invested in Crinetics Pharmaceuticals in 2025 Q3 according to their latest regulatory filings, with 41 funds opening new positions, 86 increasing their positions, 73 reducing their positions, and 35 closing their positions.

New
Increased
Maintained
Reduced
Closed

416% more call options, than puts

Call options by funds: $45.9M | Put options by funds: $8.9M

49% more capital invested

Capital invested by funds: $3.01B → $4.49B (+$1.48B)

33% more funds holding in top 10

Funds holding in top 10: 68 (+2)

18% more repeat investments, than reductions

Existing positions increased: 86 | Existing positions reduced: 73

17% more first-time investments, than exits

New positions opened: 41 | Existing positions closed: 35

2.69% more ownership

Funds ownership: 111.68%114.37% (+2.7%)

1% more funds holding

Funds holding: 222225 (+3)

Holders
225
Holders Change
+3
Holders Change %
+1.35%
% of All Funds
2.95%
Holding in Top 10
8
Holding in Top 10 Change
+2
Holding in Top 10 Change %
+33.33%
% of All Funds
0.1%
New
41
Increased
86
Reduced
73
Closed
35
Calls
$45.9M
Puts
$8.9M
Net Calls
+$37M
Net Calls Change
+$34.3M
Name Holding Trade Value Shares
Change
Change in
Stake
Fidelity Investments
1
Fidelity Investments
Massachusetts
$591M +$1.97M +61,499 +0.4%
Vanguard Group
2
Vanguard Group
Pennsylvania
$382M -$2.75M -86,003 -0.9%
Wellington Management Group
3
Wellington Management Group
Massachusetts
$349M +$82.3M +2,574,683 +44%
BlackRock
4
BlackRock
New York
$316M +$5.37M +167,882 +2%
DCM
5
Driehaus Capital Management
Illinois
$270M +$2.61M +81,588 +1%
FCM
6
Farallon Capital Management
California
$240M +$35.9M +1,124,000 +24%
T. Rowe Price Associates
7
T. Rowe Price Associates
Maryland
$221M -$9.09M -284,256 -5%
EC
8
EcoR1 Capital
California
$179M
Janus Henderson Group
9
Janus Henderson Group
United Kingdom
$161M +$14.3M +448,471 +13%
PBA
10
Paradigm Biocapital Advisors
New York
$106M +$6.63M +207,221 +9%
Geode Capital Management
11
Geode Capital Management
Massachusetts
$94.9M +$2.09M +65,505 +3%
State Street
12
State Street
Massachusetts
$92M -$32.5M -1,016,599 -32%
Jennison Associates
13
Jennison Associates
New York
$85.2M +$1.84M +57,616 +3%
Point72 Asset Management
14
Point72 Asset Management
Connecticut
$83.4M +$165K +5,172 +0.3%
SL
15
Siren LLC
Connecticut
$70.3M
NHAS
16
Novo Holdings A/S
Denmark
$67.7M +$2.4M +75,000 +5%
Pictet Asset Management
17
Pictet Asset Management
Switzerland
$61M +$8.47M +264,785 +22%
JP Morgan Chase
18
JP Morgan Chase
New York
$52.4M +$29.6M +926,765 +279%
American Century Companies
19
American Century Companies
Missouri
$47.2M +$9.11M +284,897 +34%
O
20
OrbiMed
New York
$45.8M -$1.6M -50,000 -4%
FLAM
21
First Light Asset Management
Minnesota
$39.2M +$2.47M +77,380 +9%
Citadel Advisors
22
Citadel Advisors
Florida
$36.8M +$7.38M +230,872 +35%
HRCM
23
Hood River Capital Management
Florida
$36.8M -$175K -5,466 -0.6%
RI
24
RTW Investments
New York
$36.3M +$13M +405,387 +87%
GKIM
25
GW&K Investment Management
Massachusetts
$35.4M -$3.85M -120,264 -12%

CRNX Hedge Fund Activity: Q3 2025 in Review

225 of the 7,621 institutional investors tracked by Wall St. Rank reported a position in Crinetics Pharmaceuticals (CRNX) for Q3 2025, worth a combined $4.49B — up 49% from $3.01B a quarter earlier.

Buyers outnumbered sellers: 41 funds opened new CRNX positions and 35 closed out — a net gain of 6 holders — while 86 added to existing stakes and 73 trimmed.

The largest buyer was Wellington Management Group, adding an estimated $82.3M. The largest seller was State Street, cutting an estimated $32.5M.

  • 225 institutional investors held Crinetics Pharmaceuticals (CRNX) as of Q3 2025, up from 222 in Q2 2025.
  • Funds reported $4.49B of Crinetics Pharmaceuticals stock for Q3 2025, up 49% quarter-over-quarter.
  • 41 funds opened new Crinetics Pharmaceuticals positions in Q3 2025 and 35 closed out, a net change of +6 holders.
  • The largest Crinetics Pharmaceuticals buyer in Q3 2025 was Wellington Management Group, an estimated $82.3M added.
  • The largest Crinetics Pharmaceuticals seller in Q3 2025 was State Street, an estimated $32.5M sold.

Based on aggregated 13F filings for Q3 2025.