CalciMedica
CALC
30 hedge funds and large institutions have $24.1M invested in CalciMedica in 2025 Q4 according to their latest regulatory filings, with 6 funds opening new positions, 5 increasing their positions, 8 reducing their positions, and 6 closing their positions.
120% more capital invested
Capital invested by funds: $10.9M → $24.1M (+$13.1M)
0% more first-time investments, than exits
New positions opened: 6 | Existing positions closed: 6
0.18% less ownership
Funds ownership: 25.54% → 25.37% (-0.18%)
3% less funds holding
Funds holding: 31 → 30 (-1)
38% less repeat investments, than reductions
Existing positions increased: 5 | Existing positions reduced: 8
Top Buyers
| 1 |
BFM
Boothbay Fund Management
New York
|
+$300K |
| 2 |
PAM
PVG Asset Management
Golden,
Colorado
|
+$179K |
| 3 |
Vanguard Group
Malvern,
Pennsylvania
|
+$122K |
| 4 |
Jane Street
New York
|
+$74.9K |
| 5 |
Renaissance Technologies
New York
|
+$71.4K |
Top Sellers
| 1 |
Millennium Management
New York
|
-$76.2K |
| 2 |
Envestnet Asset Management
Chicago,
Illinois
|
-$52.7K |
| 3 |
TW
TritonPoint Wealth
Chevy Chase,
Maryland
|
-$46.5K |
| 4 |
XT
XTX Topco
George Town,
Cayman Islands
|
-$46.3K |
| 5 |
1WA
180 Wealth Advisors
Federal Way,
Washington
|
-$42.3K |
| Name | Holding | Trade Value |
Shares Change |
Change in Stake |
|
|---|---|---|---|---|---|
|
BBHC
26
Brown Brothers Harriman & Co
New York
| $2.03K | – | – | – |
|
27
Osaic Holdings
Scottsdale,
Arizona
| $705 | -$3.63K | -931 | -90% |
|
|
SS
28
SBI Securities
Tokyo,
Japan
| $593 | -$125 | -32 | -26% |
|
29
BNP Paribas Financial Markets
Paris,
France
| $125 | – | – | – |
|
30
Wells Fargo
San Francisco,
California
| $66 | +$39 | +10 | New |
|
|
XT
31
XTX Topco
George Town,
Cayman Islands
| – | -$46.3K | -15,345 | Closed |
|
|
TW
32
TritonPoint Wealth
Chevy Chase,
Maryland
| – | -$46.5K | -15,119 | Closed |
|
33
Citigroup
New York
| – | -$15.2K | -4,927 | Closed |
|
34
Morgan Stanley
New York
| – | -$2.63K | -856 | Closed |
|
|
TRCT
35
Tower Research Capital (TRC)
New York
| – | -$2.05K | -666 | Closed |
|
36
Barclays
London,
United Kingdom
| – | -$175 | -57 | Closed |
|
CALC Hedge Fund Activity: Q4 2025 in Review
30 of the 8,223 institutional investors tracked by Wall St. Rank reported a position in CalciMedica (CALC) for Q4 2025, worth a combined $24.1M — up 120% from $10.9M a quarter earlier.
Fund positioning in CALC was balanced in Q4 2025: 6 funds opened new positions, 6 closed out, 5 added to existing stakes and 8 trimmed.
The largest buyer was Boothbay Fund Management, opening a new position worth an estimated $300K. The largest seller was Millennium Management, cutting an estimated $76.2K.
- 30 institutional investors held CalciMedica (CALC) as of Q4 2025, down from 31 in Q3 2025.
- Funds reported $24.1M of CalciMedica stock for Q4 2025, up 120% quarter-over-quarter.
- 6 funds opened new CalciMedica positions in Q4 2025 and 6 closed out, a net change of 0 holders.
- The largest CalciMedica buyer in Q4 2025 was Boothbay Fund Management, an estimated $300K added.
- The largest CalciMedica seller in Q4 2025 was Millennium Management, an estimated $76.2K sold.
Based on aggregated 13F filings for Q4 2025.