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BCYC

Bicycle Therapeutics

109 hedge funds and large institutions have $278M invested in Bicycle Therapeutics in 2025 Q4 according to their latest regulatory filings, with 22 funds opening new positions, 35 increasing their positions, 29 reducing their positions, and 11 closing their positions.

New
Increased
Maintained
Reduced
Closed

146% more call options, than puts

Call options by funds: $2.33M | Put options by funds: $947K

100% more funds holding in top 10

Funds holding in top 10: 12 (+1)

100% more first-time investments, than exits

New positions opened: 22 | Existing positions closed: 11

21% more repeat investments, than reductions

Existing positions increased: 35 | Existing positions reduced: 29

10% more funds holding

Funds holding: 99109 (+10)

4.45% more ownership

Funds ownership: 74.01%78.46% (+4.4%)

3% less capital invested

Capital invested by funds: $286M → $278M (-$7.96M)

Holders
109
Holders Change
+10
Holders Change %
+10.1%
% of All Funds
1.33%
Holding in Top 10
2
Holding in Top 10 Change
+1
Holding in Top 10 Change %
+100%
% of All Funds
0.02%
New
22
Increased
35
Reduced
29
Closed
11
Calls
$2.33M
Puts
$947K
Net Calls
+$1.39M
Net Calls Change
+$1.02M
Name Holding Trade Value Shares
Change
Change in
Stake
EP
26
Eversept Partners
New York
$1.27M -$114K -15,525 -8%
FPC
27
Flax Pond Capital
Massachusetts
$1.23M +$1.28M +173,633 New
TD Asset Management
28
TD Asset Management
Ontario, Canada
$1.05M -$222K -30,100 -17%
Two Sigma Advisers
29
Two Sigma Advisers
New York
$1.03M -$78.2K -10,600 -7%
FISPB
30
Fideuram - Intesa Sanpaolo Private Banking
$954K +$993K +134,689 New
Two Sigma Investments
31
Two Sigma Investments
New York
$935K -$387K -52,505 -28%
RC
32
Rangeley Capital
Connecticut
$935K +$14.7K +2,000 +2%
Manulife (Manufacturers Life Insurance)
33
Manulife (Manufacturers Life Insurance)
Ontario, Canada
$869K -$93.1K -12,629 -9%
DekaBank Deutsche Girozentrale
34
DekaBank Deutsche Girozentrale
Germany
$801K
Walleye Capital
35
Walleye Capital
New York
$791K +$823K +111,659 New
Susquehanna International Group
36
Susquehanna International Group
Pennsylvania
$768K +$603K +81,794 +307%
Bank of America
37
Bank of America
North Carolina
$683K -$3.65M -495,134 -84%
MCM
38
Monimus Capital Management
New Jersey
$664K +$63.5K +8,616 +10%
MG
39
Marex Group
$555K +$578K +78,406 New
Point72 Asset Management
40
Point72 Asset Management
Connecticut
$544K -$2.61M -354,121 -82%
State Street
41
State Street
Massachusetts
$497K -$31.2K -4,227 -6%
NFGH
42
Nan Fung Group Holdings
Hong Kong
$488K
DCM
43
DAFNA Capital Management
California
$457K
Jane Street
44
Jane Street
New York
$447K -$290K -39,269 -38%
State of Tennessee, Department of Treasury
45
State of Tennessee, Department of Treasury
Tennessee
$393K +$120K +16,311 +36%
SEI Investments
46
SEI Investments
Pennsylvania
$347K
XT
47
XTX Topco
Cayman Islands
$338K +$266K +36,026 +309%
QC
48
Quadrature Capital
United Kingdom
$331K +$139K +18,834 +68%
Man Group
49
Man Group
United Kingdom
$303K +$14.5K +1,969 +5%
AA
50
ALPS Advisors
Colorado
$290K +$124K +16,872 +70%

BCYC Hedge Fund Activity: Q4 2025 in Review

109 of the 8,223 institutional investors tracked by Wall St. Rank reported a position in Bicycle Therapeutics (BCYC) for Q4 2025, worth a combined $278M — down 2.8% from $286M a quarter earlier.

Buyers outnumbered sellers: 22 funds opened new BCYC positions and 11 closed out — a net gain of 11 holders — while 35 added to existing stakes and 29 trimmed.

The largest buyer was Schroder Investment Management Group, opening a new position worth an estimated $4.31M. The largest seller was Millennium Management, cutting an estimated $5.37M.

  • 109 institutional investors held Bicycle Therapeutics (BCYC) as of Q4 2025, up from 99 in Q3 2025.
  • Funds reported $278M of Bicycle Therapeutics stock for Q4 2025, down 2.8% quarter-over-quarter.
  • 22 funds opened new Bicycle Therapeutics positions in Q4 2025 and 11 closed out, a net change of +11 holders.
  • The largest Bicycle Therapeutics buyer in Q4 2025 was Schroder Investment Management Group, an estimated $4.31M added.
  • The largest Bicycle Therapeutics seller in Q4 2025 was Millennium Management, an estimated $5.37M sold.

Based on aggregated 13F filings for Q4 2025.