Two Sigma Investments
BCYC

Two Sigma Investments’s Bicycle Therapeutics BCYC Stock Holding History

Two Sigma Investments’s Portfolio BCYC Stock Details BCYC Fund Activity
Bought
Maintained
Sold
Quarter Market Value Status Shares Change in
Stake 		Trade Value Portfolio Weight Portfolio Position
2026
Q1 		$765K Buy
164,800
+32,768
+25% +$187K ﹤0.01% 3450
2025
Q4 		$935K Sell
132,032
-52,505
-28% -$387K ﹤0.01% 2962
2025
Q3 		$1.43M Buy
184,537
+128,339
+228% +$969K ﹤0.01% 2348
2025
Q2 		$391K Buy
+56,198
New +$448K ﹤0.01% 2682
2024
Q3 		– Sell
-26,583
Closed -$538K – 3118
2024
Q2 		$538K Sell
26,583
-2,002
-7% -$45.2K ﹤0.01% 2335
2024
Q1 		$712K Sell
28,585
-75,043
-72% -$1.59M ﹤0.01% 2158
2023
Q4 		$1.87M Buy
103,628
+80,698
+352% +$1.34M ﹤0.01% 1620
2023
Q3 		$461K Sell
22,930
-29,696
-56% -$679K ﹤0.01% 2314
2023
Q2 		$1.34M Sell
52,626
-107,950
-67% -$2.51M ﹤0.01% 1768
2023
Q1 		$3.42M Buy
+160,576
New +$4.03M 0.01% 1085
2022
Q4 		– Sell
-49,500
Closed -$1.15M – 2805
2022
Q3 		$1.15M Sell
49,500
-331,154
-87% -$7.88M ﹤0.01% 1395
2022
Q2 		$6.39M Buy
380,654
+203,332
+115% +$4.29M 0.02% 667
2022
Q1 		$7.78M Buy
177,322
+25,961
+17% +$1.21M 0.02% 706
2021
Q4 		$9.21M Buy
151,361
+59,169
+64% +$3.26M 0.02% 838
2021
Q3 		$3.83M Buy
+92,192
New +$3.22M 0.01% 1435
2021
Q1 		– Sell
-20,399
Closed -$366K – 3814
2020
Q4 		$366K Buy
+20,399
New +$394K ﹤0.01% 2724

Other funds holding BCYC

BBA
Baker Bros. Advisors New York $17.4B AUM 131.5% 1-Year Est. Return
FIS
FCPM III Services Naarden, Netherlands $722M AUM 73.61% 1-Year Est. Return
AC
Armistice Capital New York $5.62B AUM 36.06% 1-Year Est. Return
LFCM
Long Focus Capital Management San Juan, Puerto Rico $3.8B AUM 7.31% 1-Year Est. Return
Acadian Asset Management
Acadian Asset Management Boston, Massachusetts $70.5B AUM 36% 1-Year Est. Return
SL
Siren LLC Greenwich, Connecticut $3.61B AUM 203.3% 1-Year Est. Return
GP
GSK plc London $599M AUM
Principal Financial Group
Principal Financial Group Des Moines, Iowa $187B AUM 18.48% 1-Year Est. Return
T. Rowe Price Associates
T. Rowe Price Associates Baltimore, Maryland $865B AUM 30.76% 1-Year Est. Return
Renaissance Technologies
Renaissance Technologies New York $63.9B AUM 45.56% 1-Year Est. Return

Two Sigma Investments's BCYC Position: Q1 2026 in Review

Two Sigma Investments increased its Bicycle Therapeutics (BCYC) stake by 25% in Q1 2026, buying an estimated $187K and bringing the position to 164,800 shares worth $765K. The position accounts for ﹤0.01% of the portfolio, ranked #3450.

Two Sigma Investments first reported a position in BCYC in Q4 2020 and has held it in 16 quarters since. The position peaked at $9.21M in Q4 2021. 98 funds tracked by Wall St. Rank hold BCYC as of Q1 2026.

  • Two Sigma Investments held 164,800 shares of Bicycle Therapeutics worth $765K as of Q1 2026.
  • Two Sigma Investments bought 32,768 Bicycle Therapeutics shares in Q1 2026, an estimated $187K.
  • Bicycle Therapeutics made up ﹤0.01% of Two Sigma Investments's portfolio in Q1 2026, its #3450 holding.
  • Two Sigma Investments first reported a position in Bicycle Therapeutics in Q4 2020 and has held it in 16 quarters since.
  • Two Sigma Investments's Bicycle Therapeutics position peaked at $9.21M in Q4 2021.
  • 98 funds tracked by Wall St. Rank held Bicycle Therapeutics as of Q1 2026.

Based on Two Sigma Investments's 13F filing for Q1 2026, filed 15 May 2026.