Annexon
ANNX
217 hedge funds and large institutions have $864M invested in Annexon in 2026 Q1 according to their latest regulatory filings, with 66 funds opening new positions, 86 increasing their positions, 50 reducing their positions, and 15 closing their positions.
665% more call options, than puts
Call options by funds: $6.69M | Put options by funds: $875K
340% more first-time investments, than exits
New positions opened: 66 | Existing positions closed: 15
72% more repeat investments, than reductions
Existing positions increased: 86 | Existing positions reduced: 50
29% more funds holding
Funds holding: 168 → 217 (+49)
26% more capital invested
Capital invested by funds: $687M → $864M (+$176M)
25% more funds holding in top 10
Funds holding in top 10: 4 → 5 (+1)
15.9% more ownership
Funds ownership: 114.45% → 130.36% (+16%)
Top Buyers
| Rank | Fund | Capital Flow |
|---|---|---|
| 1 |
RG
Redmile Group
San Francisco,
California
|
+$25.3M |
| 2 |
SL
Siren LLC
Greenwich,
Connecticut
|
+$22.3M |
| 3 |
Bank of America
Charlotte,
North Carolina
|
+$14.9M |
| 4 |
GPP
Great Point Partners
Greenwich,
Connecticut
|
+$14.1M |
| 5 |
State Street
Boston,
Massachusetts
|
+$12.8M |
Top Sellers
| Rank | Fund | Capital Flow |
|---|---|---|
| 1 |
LP
Longaeva Partners
Chicago,
Illinois
|
-$14M |
| 2 |
WP
Woodline Partners
San Francisco,
California
|
-$9.36M |
| 3 |
Millennium Management
New York
|
-$9M |
| 4 |
Adage Capital Partners
Boston,
Massachusetts
|
-$6.76M |
| 5 |
SFM
Sphera Funds Management
Tel Aviv,
Israel
|
-$6.61M |
| Name | Holding | Trade Value |
Shares Change |
Change in Stake |
|
|---|---|---|---|---|---|
226
HSBC Holdings
London,
United Kingdom
| – | -$130K | -25,651 | Closed |
|
227
Group One Trading
Chicago,
Illinois
| – | -$79.8K | -14,184 | Closed |
|
228
Simplex Trading
Chicago,
Illinois
| – | -$57.8K | -10,268 | Closed |
|
|
AB
229
Amalgamated Bank
New York
| – | -$16K | -3,144 | Closed |
|
230
Daiwa Securities Group
Tokyo,
Japan
| – | -$2K | -352 | Closed |
|
231
AssetMark Inc
Concord,
California
| – | -$1.67K | -333 | Closed |
|
232
Northwestern Mutual Wealth Management
Milwaukee,
Wisconsin
| – | -$20 | -4 | Closed |
|
ANNX Hedge Fund Activity: Q1 2026 in Review
217 of the 8,126 institutional investors tracked by Wall St. Rank reported a position in Annexon (ANNX) for Q1 2026, worth a combined $864M — up 26% from $687M a quarter earlier.
Buyers outnumbered sellers: 66 funds opened new ANNX positions and 15 closed out — a net gain of 51 holders — while 86 added to existing stakes and 50 trimmed.
The largest buyer was Redmile Group, adding an estimated $25.3M. The largest seller was Longaeva Partners, cutting an estimated $14M.
- 217 institutional investors held Annexon (ANNX) as of Q1 2026, up from 168 in Q4 2025.
- Funds reported $864M of Annexon stock for Q1 2026, up 26% quarter-over-quarter.
- 66 funds opened new Annexon positions in Q1 2026 and 15 closed out, a net change of +51 holders.
- The largest Annexon buyer in Q1 2026 was Redmile Group, an estimated $25.3M added.
- The largest Annexon seller in Q1 2026 was Longaeva Partners, an estimated $14M sold.
Based on aggregated 13F filings for Q1 2026.