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Alnylam Pharmaceuticals

Name Holding Trade Value Shares
Change
Change in
Stake
Invesco
26
Invesco
Georgia
$131M -$36.1M -137,378 -20%
Deutsche Bank
27
Deutsche Bank
Germany
$131M +$4.55M +17,308 +3%
Charles Schwab
28
Charles Schwab
California
$121M +$7M +26,614 +5%
Amundi
29
Amundi
France
$119M -$25.5M -97,019 -16%
TD Asset Management
30
TD Asset Management
Ontario, Canada
$119M +$4.14M +15,755 +3%
Loomis, Sayles & Company
31
Loomis, Sayles & Company
Massachusetts
$118M -$5.85M -22,258 -4%
Qube Research & Technologies (QRT)
32
Qube Research & Technologies (QRT)
United Kingdom
$114M +$87.6M +333,098 +219%
Bank of New York Mellon
33
Bank of New York Mellon
New York
$113M +$1.25M +4,764 +1%
Nuveen
34
Nuveen
North Carolina
$106M +$2.05M +7,789 +2%
Pictet Asset Management
35
Pictet Asset Management
Switzerland
$101M -$61.6M -234,110 -35%
Bank of America
36
Bank of America
North Carolina
$98.5M -$34.8M -132,220 -24%
O
37
OrbiMed
New York
$97.8M +$43.5M +165,300 +66%
Franklin Resources
38
Franklin Resources
California
$97.5M +$8.2M +31,166 +8%
Marshall Wace
39
Marshall Wace
United Kingdom
$89.1M +$82.9M +315,182 +497%
GGHC
40
Gilder Gagnon Howe & Co
New York
$86M -$4.87M -18,530 -5%
D.E. Shaw & Co
41
D.E. Shaw & Co
New York
$85.4M +$8.09M +30,780 +9%
Swiss National Bank
42
Swiss National Bank
Switzerland
$85.3M -$3.37M -12,800 -3%
Dimensional Fund Advisors
43
Dimensional Fund Advisors
Texas
$78.5M +$8.49M +32,272 +11%
Millennium Management
44
Millennium Management
New York
$78.5M +$21.7M +82,479 +33%
First Trust Advisors
45
First Trust Advisors
Illinois
$77.1M +$11.1M +42,211 +15%
Royal Bank of Canada
46
Royal Bank of Canada
Ontario, Canada
$73M -$26.5M -100,879 -25%
PCH
47
Polar Capital Holdings
United Kingdom
$72.9M
Goldman Sachs
48
Goldman Sachs
New York
$72.1M -$13.1M -49,645 -14%
UBS Group
49
UBS Group
Switzerland
$68.2M +$35.3M +134,295 +86%
Sumitomo Mitsui Trust Group
50
Sumitomo Mitsui Trust Group
Japan
$67.5M +$2.23M +8,462 +3%