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Alnylam Pharmaceuticals

839 hedge funds and large institutions have $51.7B invested in Alnylam Pharmaceuticals in 2025 Q4 according to their latest regulatory filings, with 165 funds opening new positions, 286 increasing their positions, 289 reducing their positions, and 118 closing their positions.

New
Increased
Maintained
Reduced
Closed

more call options, than puts

Call options by funds: $ | Put options by funds: $

more first-time investments, than exits

New positions opened: | Existing positions closed:

more funds holding

Funds holding:

less ownership

Funds ownership:

1% less repeat investments, than reductions

Existing positions increased: 286 | Existing positions reduced: 289

13% less capital invested

Capital invested by funds: $59.2B → $51.7B (-$7.51B)

69% less funds holding in top 10

Funds holding in top 10: 134 (-9)

Holders
839
Holders Change
Holders Change %
% of All Funds
Holding in Top 10
4
Holding in Top 10 Change
Holding in Top 10 Change %
% of All Funds
New
Increased
Reduced
Closed
Calls
$760M
Puts
$494M
Net Calls
Net Calls Change

Top Buyers

1 +$303M
2 +$220M
3 +$149M
4
D.E. Shaw & Co
D.E. Shaw & Co
New York
+$108M
5
Morgan Stanley
Morgan Stanley
New York
+$108M

Top Sellers

1 -$635M
2 -$383M
3 -$360M
4
Jane Street
Jane Street
New York
-$287M
5
Macquarie Group
Macquarie Group
Australia
-$276M
Name Holding Trade Value Shares
Change
Change in
Stake
VMPIC
201
Varma Mutual Pension Insurance Co
Finland
$10.4M
EAM
202
Erste Asset Management
Austria
$10.4M
Daiwa Securities Group
203
Daiwa Securities Group
Japan
$10.3M
IMRF
204
Illinois Municipal Retirement Fund
Illinois
$10.2M
QCM
205
Quantinno Capital Management
New York
$10.2M
Assenagon Asset Management
206
Assenagon Asset Management
Luxembourg
$10.2M
Carson Wealth (CWM LLC)
207
Carson Wealth (CWM LLC)
Nebraska
$10.1M
Macquarie Group
208
Macquarie Group
Australia
$10.1M
CUAMC
209
China Universal Asset Management Company
China
$10M
MMC
210
Mizuho Markets Cayman
Cayman Islands
$9.92M
Brown Advisory
211
Brown Advisory
Maryland
$9.88M
Cerity Partners
212
Cerity Partners
New York
$9.77M
ECSS
213
Eurizon Capital SGR SpA
$9.71M
Creative Planning
214
Creative Planning
Kansas
$9.47M
BCIM
215
British Columbia Investment Management
British Columbia, Canada
$9.23M
Toronto Dominion Bank
216
Toronto Dominion Bank
Ontario, Canada
$9.23M
SLAM
217
Swiss Life Asset Management
$8.94M
Nomura Holdings
218
Nomura Holdings
Japan
$8.92M
BBVA
219
Banco Bilbao Vizcaya Argentaria
Spain
$8.72M
Credit Agricole
220
Credit Agricole
France
$8.57M
IMCOOI
221
Investment Management Corp of Ontario (IMCO)
Canada
$8.56M
Acadian Asset Management
222
Acadian Asset Management
Massachusetts
$8.47M
APM
223
Avidity Partners Management
Texas
$8.35M
Capital Fund Management (CFM)
224
Capital Fund Management (CFM)
France
$8.33M
URS
225
Utah Retirement Systems
Utah
$8.24M