ALNY icon

Alnylam Pharmaceuticals

846 hedge funds and large institutions have $51.7B invested in Alnylam Pharmaceuticals in 2025 Q4 according to their latest regulatory filings, with 169 funds opening new positions, 288 increasing their positions, 290 reducing their positions, and 118 closing their positions.

New
Increased
Maintained
Reduced
Closed

more call options, than puts

Call options by funds: $ | Put options by funds: $

more first-time investments, than exits

New positions opened: | Existing positions closed:

more funds holding

Funds holding:

less repeat investments, than reductions

Existing positions increased: | Existing positions reduced:

0.83% less ownership

Funds ownership: 99.03%98.2% (-0.83%)

13% less capital invested

Capital invested by funds: $59.2B → $51.7B (-$7.48B)

69% less funds holding in top 10

Funds holding in top 10: 134 (-9)

Holders
846
Holders Change
Holders Change %
% of All Funds
Holding in Top 10
4
Holding in Top 10 Change
Holding in Top 10 Change %
% of All Funds
New
Increased
Reduced
Closed
Calls
$760M
Puts
$494M
Net Calls
Net Calls Change

Top Buyers

1 +$303M
2 +$220M
3 +$149M
4
D.E. Shaw & Co
D.E. Shaw & Co
New York
+$108M
5
Morgan Stanley
Morgan Stanley
New York
+$108M

Top Sellers

1 -$635M
2 -$383M
3 -$360M
4
Jane Street
Jane Street
New York
-$287M
5
Macquarie Group
Macquarie Group
Australia
-$276M
Name Holding Trade Value Shares
Change
Change in
Stake
UIM
201
USS Investment Management
United Kingdom
$10.4M
VMPIC
202
Varma Mutual Pension Insurance Co
Finland
$10.4M
EAM
203
Erste Asset Management
Austria
$10.4M
Daiwa Securities Group
204
Daiwa Securities Group
Japan
$10.3M
IMRF
205
Illinois Municipal Retirement Fund
Illinois
$10.2M
QCM
206
Quantinno Capital Management
New York
$10.2M
Assenagon Asset Management
207
Assenagon Asset Management
Luxembourg
$10.2M
Carson Wealth (CWM LLC)
208
Carson Wealth (CWM LLC)
Nebraska
$10.1M
Macquarie Group
209
Macquarie Group
Australia
$10.1M
CUAMC
210
China Universal Asset Management Company
China
$10M
MMC
211
Mizuho Markets Cayman
Cayman Islands
$9.92M
Brown Advisory
212
Brown Advisory
Maryland
$9.88M
Cerity Partners
213
Cerity Partners
New York
$9.77M
ECSS
214
Eurizon Capital SGR SpA
$9.71M
Creative Planning
215
Creative Planning
Kansas
$9.47M
BCIM
216
British Columbia Investment Management
British Columbia, Canada
$9.23M
Toronto Dominion Bank
217
Toronto Dominion Bank
Ontario, Canada
$9.23M
SLAM
218
Swiss Life Asset Management
$8.94M
Nomura Holdings
219
Nomura Holdings
Japan
$8.92M
BBVA
220
Banco Bilbao Vizcaya Argentaria
Spain
$8.72M
Credit Agricole
221
Credit Agricole
France
$8.57M
IMCOOI
222
Investment Management Corp of Ontario (IMCO)
Canada
$8.56M
Acadian Asset Management
223
Acadian Asset Management
Massachusetts
$8.47M
APM
224
Avidity Partners Management
Texas
$8.35M
Capital Fund Management (CFM)
225
Capital Fund Management (CFM)
France
$8.33M