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Alnylam Pharmaceuticals

832 hedge funds and large institutions have $51.6B invested in Alnylam Pharmaceuticals in 2025 Q4 according to their latest regulatory filings, with 160 funds opening new positions, 283 increasing their positions, 290 reducing their positions, and 115 closing their positions.

New
Increased
Maintained
Reduced
Closed

more call options, than puts

Call options by funds: $ | Put options by funds: $

more first-time investments, than exits

New positions opened: | Existing positions closed:

more funds holding

Funds holding:

less ownership

Funds ownership:

2% less repeat investments, than reductions

Existing positions increased: 283 | Existing positions reduced: 290

13% less capital invested

Capital invested by funds: $59.2B → $51.6B (-$7.57B)

69% less funds holding in top 10

Funds holding in top 10: 134 (-9)

Holders
832
Holders Change
Holders Change %
% of All Funds
Holding in Top 10
4
Holding in Top 10 Change
Holding in Top 10 Change %
% of All Funds
New
Increased
Reduced
Closed
Calls
$760M
Puts
$448M
Net Calls
Net Calls Change

Top Buyers

1 +$303M
2 +$220M
3 +$158M
4
UBS Group
UBS Group
Switzerland
+$149M
5
D.E. Shaw & Co
D.E. Shaw & Co
New York
+$108M

Top Sellers

1 -$635M
2 -$383M
3 -$360M
4
Jane Street
Jane Street
New York
-$287M
5
Macquarie Group
Macquarie Group
Australia
-$276M
Name Holding Trade Value Shares
Change
Change in
Stake
IMRF
201
Illinois Municipal Retirement Fund
Illinois
$10.2M
QCM
202
Quantinno Capital Management
New York
$10.2M
Assenagon Asset Management
203
Assenagon Asset Management
Luxembourg
$10.2M
Carson Wealth (CWM LLC)
204
Carson Wealth (CWM LLC)
Nebraska
$10.1M
Macquarie Group
205
Macquarie Group
Australia
$10.1M
CUAMC
206
China Universal Asset Management Company
China
$10M
MMC
207
Mizuho Markets Cayman
Cayman Islands
$9.92M
Brown Advisory
208
Brown Advisory
Maryland
$9.88M
Cerity Partners
209
Cerity Partners
New York
$9.77M
ECSS
210
Eurizon Capital SGR SpA
$9.71M
Creative Planning
211
Creative Planning
Kansas
$9.47M
Corient Private Wealth
212
Corient Private Wealth
Florida
$9.4M
BCIM
213
British Columbia Investment Management
British Columbia, Canada
$9.23M
Toronto Dominion Bank
214
Toronto Dominion Bank
Ontario, Canada
$9.23M
SLAM
215
Swiss Life Asset Management
$8.94M
Nomura Holdings
216
Nomura Holdings
Japan
$8.92M
BBVA
217
Banco Bilbao Vizcaya Argentaria
Spain
$8.72M
Credit Agricole
218
Credit Agricole
France
$8.57M
IMCOOI
219
Investment Management Corp of Ontario (IMCO)
Canada
$8.56M
Acadian Asset Management
220
Acadian Asset Management
Massachusetts
$8.47M
APM
221
Avidity Partners Management
Texas
$8.35M
Capital Fund Management (CFM)
222
Capital Fund Management (CFM)
France
$8.33M
URS
223
Utah Retirement Systems
Utah
$8.24M
Thrivent Financial for Lutherans
224
Thrivent Financial for Lutherans
Minnesota
$8.21M
FISPB
225
Fideuram - Intesa Sanpaolo Private Banking
$8.14M