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Alnylam Pharmaceuticals

839 hedge funds and large institutions have $51.7B invested in Alnylam Pharmaceuticals in 2025 Q4 according to their latest regulatory filings, with 165 funds opening new positions, 286 increasing their positions, 289 reducing their positions, and 118 closing their positions.

New
Increased
Maintained
Reduced
Closed

more call options, than puts

Call options by funds: $ | Put options by funds: $

more first-time investments, than exits

New positions opened: | Existing positions closed:

more funds holding

Funds holding:

less ownership

Funds ownership:

1% less repeat investments, than reductions

Existing positions increased: 286 | Existing positions reduced: 289

13% less capital invested

Capital invested by funds: $59.2B → $51.7B (-$7.51B)

69% less funds holding in top 10

Funds holding in top 10: 134 (-9)

Holders
839
Holders Change
Holders Change %
% of All Funds
Holding in Top 10
4
Holding in Top 10 Change
Holding in Top 10 Change %
% of All Funds
New
Increased
Reduced
Closed
Calls
$760M
Puts
$494M
Net Calls
Net Calls Change

Top Buyers

1 +$303M
2 +$220M
3 +$149M
4
D.E. Shaw & Co
D.E. Shaw & Co
New York
+$108M
5
Morgan Stanley
Morgan Stanley
New York
+$108M

Top Sellers

1 -$635M
2 -$383M
3 -$360M
4
Jane Street
Jane Street
New York
-$287M
5
Macquarie Group
Macquarie Group
Australia
-$276M
Name Holding Trade Value Shares
Change
Change in
Stake
ASRS
176
Arizona State Retirement System
Arizona
$14.5M
GAM
177
Groupama Asset Management
France
$14.3M
NAM
178
Nissay Asset Management
Japan
$14.2M
Lord, Abbett & Co
179
Lord, Abbett & Co
New Jersey
$14.1M
PPF
180
PFA Pension Forsikringsaktieselskab
$14.1M
Bank of Montreal
181
Bank of Montreal
Ontario, Canada
$14M
EAM
182
Eventide Asset Management
Massachusetts
$13.5M
RSS
183
Rosenblum Silverman Sutton
California
$13.2M
TRSOTSOK
184
Teachers Retirement System of the State of Kentucky
Kentucky
$12.6M
PAM
185
Panagora Asset Management
Massachusetts
$12.3M
DnB Asset Management
186
DnB Asset Management
Norway
$12.2M
JF
187
Jump Financial
Illinois
$12.2M
GFM
188
GF Fund Management
China
$12.1M
ZIG
189
Zurich Insurance Group
Switzerland
$12.1M
FAF
190
Fjarde Ap-fonden
Sweden
$12M
OBAM
191
ODDO BHF Asset Management
France
$12M
CIBC Asset Management
192
CIBC Asset Management
Ontario, Canada
$11.9M
SO
193
STRS Ohio
Ohio
$11.1M
USCWA
194
U.S. Capital Wealth Advisors
Texas
$10.9M
X
195
Xponance
Pennsylvania
$10.9M
TI
196
Trexquant Investment
Connecticut
$10.6M
EI
197
EFG International
$10.5M
JFG
198
Jefferies Financial Group
New York
$10.5M
II
199
IFM Investors
Australia
$10.4M
UIM
200
USS Investment Management
United Kingdom
$10.4M