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Alnylam Pharmaceuticals

839 hedge funds and large institutions have $51.7B invested in Alnylam Pharmaceuticals in 2025 Q4 according to their latest regulatory filings, with 165 funds opening new positions, 286 increasing their positions, 289 reducing their positions, and 118 closing their positions.

New
Increased
Maintained
Reduced
Closed

more call options, than puts

Call options by funds: $ | Put options by funds: $

more first-time investments, than exits

New positions opened: | Existing positions closed:

more funds holding

Funds holding:

less ownership

Funds ownership:

1% less repeat investments, than reductions

Existing positions increased: 286 | Existing positions reduced: 289

13% less capital invested

Capital invested by funds: $59.2B → $51.7B (-$7.51B)

69% less funds holding in top 10

Funds holding in top 10: 134 (-9)

Holders
839
Holders Change
Holders Change %
% of All Funds
Holding in Top 10
4
Holding in Top 10 Change
Holding in Top 10 Change %
% of All Funds
New
Increased
Reduced
Closed
Calls
$760M
Puts
$494M
Net Calls
Net Calls Change

Top Buyers

1 +$303M
2 +$220M
3 +$149M
4
D.E. Shaw & Co
D.E. Shaw & Co
New York
+$108M
5
Morgan Stanley
Morgan Stanley
New York
+$108M

Top Sellers

1 -$635M
2 -$383M
3 -$360M
4
Jane Street
Jane Street
New York
-$287M
5
Macquarie Group
Macquarie Group
Australia
-$276M
Name Holding Trade Value Shares
Change
Change in
Stake
FAF
151
Första AP-fonden
Sweden
$18.5M
LPL Financial
152
LPL Financial
California
$18.3M
DekaBank Deutsche Girozentrale
153
DekaBank Deutsche Girozentrale
Germany
$18.2M
RPAM
154
Rhenman & Partners Asset Management
Sweden
$18.2M
Rafferty Asset Management
155
Rafferty Asset Management
New York
$17.9M
State of New Jersey Common Pension Fund D
156
State of New Jersey Common Pension Fund D
New Jersey
$17.9M
SSA
157
Schonfeld Strategic Advisors
New York
$17.9M
Osaic Holdings
158
Osaic Holdings
Arizona
$17.8M
Parnassus Investments
159
Parnassus Investments
California
$17.7M
Ohio Public Employees Retirement System (OPERS)
160
Ohio Public Employees Retirement System (OPERS)
Ohio
$17.7M
Natixis Advisors
161
Natixis Advisors
Massachusetts
$17.6M
AllianceBernstein
162
AllianceBernstein
Tennessee
$17.6M
Mariner
163
Mariner
Kansas
$16.9M
MIF
164
Mediolanum International Funds
Ireland
$16.9M
LF
165
Lansforsakringar Fondforvaltning
Sweden
$16.8M
NIM
166
NEOS Investment Management
Connecticut
$16.2M
Healthcare of Ontario Pension Plan (HOOPP) Trust Fund
167
Healthcare of Ontario Pension Plan (HOOPP) Trust Fund
Ontario, Canada
$16.1M
TAF
168
Tredje AP-fonden
Sweden
$16.1M
GC
169
Guggenheim Capital
Illinois
$16M
N
170
Natixis
France
$15.8M
GAM
171
Gotham Asset Management
New York
$15.8M
RAM
172
Resona Asset Management
Japan
$15.6M
BCM
173
Bronte Capital Management
Australia
$15.5M
Citadel Advisors
174
Citadel Advisors
Florida
$15.3M
PCMH
175
Polymer Capital Management (HK)
Hong Kong
$14.6M