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Alnylam Pharmaceuticals

832 hedge funds and large institutions have $51.6B invested in Alnylam Pharmaceuticals in 2025 Q4 according to their latest regulatory filings, with 160 funds opening new positions, 283 increasing their positions, 290 reducing their positions, and 115 closing their positions.

New
Increased
Maintained
Reduced
Closed

more call options, than puts

Call options by funds: $ | Put options by funds: $

more first-time investments, than exits

New positions opened: | Existing positions closed:

more funds holding

Funds holding:

less ownership

Funds ownership:

2% less repeat investments, than reductions

Existing positions increased: 283 | Existing positions reduced: 290

13% less capital invested

Capital invested by funds: $59.2B → $51.6B (-$7.57B)

69% less funds holding in top 10

Funds holding in top 10: 134 (-9)

Holders
832
Holders Change
Holders Change %
% of All Funds
Holding in Top 10
4
Holding in Top 10 Change
Holding in Top 10 Change %
% of All Funds
New
Increased
Reduced
Closed
Calls
$760M
Puts
$448M
Net Calls
Net Calls Change

Top Buyers

1 +$303M
2 +$220M
3 +$158M
4
UBS Group
UBS Group
Switzerland
+$149M
5
D.E. Shaw & Co
D.E. Shaw & Co
New York
+$108M

Top Sellers

1 -$635M
2 -$383M
3 -$360M
4
Jane Street
Jane Street
New York
-$287M
5
Macquarie Group
Macquarie Group
Australia
-$276M
Name Holding Trade Value Shares
Change
Change in
Stake
DekaBank Deutsche Girozentrale
151
DekaBank Deutsche Girozentrale
Germany
$18.2M
RPAM
152
Rhenman & Partners Asset Management
Sweden
$18.2M
Rafferty Asset Management
153
Rafferty Asset Management
New York
$17.9M
State of New Jersey Common Pension Fund D
154
State of New Jersey Common Pension Fund D
New Jersey
$17.9M
SSA
155
Schonfeld Strategic Advisors
New York
$17.9M
Osaic Holdings
156
Osaic Holdings
Arizona
$17.8M
Parnassus Investments
157
Parnassus Investments
California
$17.7M
Ohio Public Employees Retirement System (OPERS)
158
Ohio Public Employees Retirement System (OPERS)
Ohio
$17.7M
Natixis Advisors
159
Natixis Advisors
Massachusetts
$17.6M
AllianceBernstein
160
AllianceBernstein
Tennessee
$17.6M
Mariner
161
Mariner
Kansas
$16.9M
MIF
162
Mediolanum International Funds
Ireland
$16.9M
LF
163
Lansforsakringar Fondforvaltning
Sweden
$16.8M
NIM
164
NEOS Investment Management
Connecticut
$16.2M
Healthcare of Ontario Pension Plan (HOOPP) Trust Fund
165
Healthcare of Ontario Pension Plan (HOOPP) Trust Fund
Ontario, Canada
$16.1M
TAF
166
Tredje AP-fonden
Sweden
$16.1M
GC
167
Guggenheim Capital
Illinois
$16M
N
168
Natixis
France
$15.8M
GAM
169
Gotham Asset Management
New York
$15.8M
RAM
170
Resona Asset Management
Japan
$15.6M
BCM
171
Bronte Capital Management
Australia
$15.5M
Citadel Advisors
172
Citadel Advisors
Florida
$15.3M
PCMH
173
Polymer Capital Management (HK)
Hong Kong
$14.6M
ASRS
174
Arizona State Retirement System
Arizona
$14.5M
NAM
175
Nissay Asset Management
Japan
$14.2M