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Alnylam Pharmaceuticals

839 hedge funds and large institutions have $51.7B invested in Alnylam Pharmaceuticals in 2025 Q4 according to their latest regulatory filings, with 165 funds opening new positions, 286 increasing their positions, 289 reducing their positions, and 118 closing their positions.

New
Increased
Maintained
Reduced
Closed

more call options, than puts

Call options by funds: $ | Put options by funds: $

more first-time investments, than exits

New positions opened: | Existing positions closed:

more funds holding

Funds holding:

less ownership

Funds ownership:

1% less repeat investments, than reductions

Existing positions increased: 286 | Existing positions reduced: 289

13% less capital invested

Capital invested by funds: $59.2B → $51.7B (-$7.51B)

69% less funds holding in top 10

Funds holding in top 10: 134 (-9)

Holders
839
Holders Change
Holders Change %
% of All Funds
Holding in Top 10
4
Holding in Top 10 Change
Holding in Top 10 Change %
% of All Funds
New
Increased
Reduced
Closed
Calls
$760M
Puts
$494M
Net Calls
Net Calls Change

Top Buyers

1 +$303M
2 +$220M
3 +$149M
4
D.E. Shaw & Co
D.E. Shaw & Co
New York
+$108M
5
Morgan Stanley
Morgan Stanley
New York
+$108M

Top Sellers

1 -$635M
2 -$383M
3 -$360M
4
Jane Street
Jane Street
New York
-$287M
5
Macquarie Group
Macquarie Group
Australia
-$276M
Name Holding Trade Value Shares
Change
Change in
Stake
TCG
101
Tremblant Capital Group
Florida
$43.8M
BNP Paribas Asset Management
102
BNP Paribas Asset Management
France
$43.6M
HighTower Advisors
103
HighTower Advisors
Illinois
$42.3M
PI
104
PineBridge Investments
New York
$39.8M
Nomura Asset Management
105
Nomura Asset Management
Japan
$37.5M
Fidelity International
106
Fidelity International
Bermuda
$37.4M
Westfield Capital Management
107
Westfield Capital Management
Massachusetts
$37.2M
SG Americas Securities
108
SG Americas Securities
New York
$36.2M
HSBC Holdings
109
HSBC Holdings
United Kingdom
$35.7M
LCIP
110
Life Cycle Investment Partners
$35M
BA
111
Bridgewater Associates
Connecticut
$34M
Hudson Bay Capital Management
112
Hudson Bay Capital Management
Connecticut
$33.8M
Mirae Asset Global ETFs Holdings
113
Mirae Asset Global ETFs Holdings
Hong Kong
$31.9M
Mitsubishi UFJ Trust & Banking
114
Mitsubishi UFJ Trust & Banking
Japan
$31.6M
Millennium Management
115
Millennium Management
New York
$30M
CC
116
Casdin Capital
New York
$29.8M
RSCM
117
Rock Springs Capital Management
Maryland
$28.3M
Fiera Capital (Canada)
118
Fiera Capital (Canada)
Quebec, Canada
$28.1M
SCM
119
Soleus Capital Management
Connecticut
$27.8M
DCM
120
Driehaus Capital Management
Illinois
$27.7M
Schroder Investment Management Group
121
Schroder Investment Management Group
United Kingdom
$27M
DM
122
Deerfield Management
New York
$27M
CI
123
Capital International
California
$26.9M
DB
124
Danske Bank
Denmark
$26.7M
National Bank of Canada
125
National Bank of Canada
Quebec, Canada
$26.4M