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Alnylam Pharmaceuticals
ALNY

Overview Fund Activity

646 hedge funds and large institutions have $43B invested in Alnylam Pharmaceuticals in 2025 Q2 according to their latest regulatory filings, with 97 funds opening new positions, 257 increasing their positions, 214 reducing their positions, and 62 closing their positions.

New
Increased
Maintained
Reduced
Closed
Holders
646
Holders Change
+29
Holders Change %
+4.7%
% of All Funds
8.66%
Holding in Top 10
9
Holding in Top 10 Change
-1
Holding in Top 10 Change %
-10%
% of All Funds
0.12%
New
97
Increased
257
Reduced
214
Closed
62
Calls
$188M
Puts
$203M
Net Calls
-$15.5M
Net Calls Change
-$50.8M

Top Buyers

1
Citadel Advisors
Citadel Advisors
Florida
+$195M
2
Holocene Advisors
Holocene Advisors
New York
+$195M
3
ClearBridge Investments
ClearBridge Investments
New York
+$179M
4
Macquarie Group
Macquarie Group
Australia
+$172M
5
Fidelity Investments
Fidelity Investments
Massachusetts
+$162M

Top Sellers

1
AQR Capital Management
AQR Capital Management
Connecticut
-$208M
2
Baillie Gifford & Co
Baillie Gifford & Co
United Kingdom
-$204M
3
Wellington Management Group
Wellington Management Group
Massachusetts
-$175M
4
T. Rowe Price Associates
T. Rowe Price Associates
Maryland
-$117M
5
Qube Research & Technologies (QRT)
Qube Research & Technologies (QRT)
United Kingdom
-$89.2M
Name Holding Trade Value Shares
Change 		Shares
Change %
Neuberger Berman Group
101
Neuberger Berman Group
New York
$32.3M +$197K +605 +0.6%
Aviva
102
Aviva
United Kingdom
$31.7M +$2.29M +7,012 +8%
Robeco Institutional Asset Management
103
Robeco Institutional Asset Management
Netherlands
$31.4M -$2.32M -7,113 -7%
Envestnet Asset Management
104
Envestnet Asset Management
Illinois
$31.2M +$7.74M +23,749 +33%
Barclays
105
Barclays
United Kingdom
$30.7M -$542K -1,661 -2%
Russell Investments Group
106
Russell Investments Group
United Kingdom
$30.4M -$11.6M -35,761 -28%
PAM
107
Panagora Asset Management
Massachusetts
$30.2M -$1.4M -4,305 -4%
PHP
108
Parkman Healthcare Partners
Connecticut
$30.1M +$7.63M +23,400 +34%
Nomura Asset Management
109
Nomura Asset Management
Japan
$29.8M +$1.48M +4,531 +5%
Canada Life
110
Canada Life
Manitoba, Canada
$29.7M +$2.39M +7,326 +9%
Millennium Management
111
Millennium Management
New York
$29.5M -$64.2M -196,892 -69%
TLP
112
Tri Locum Partners
New York
$29.2M +$29.2M +89,525 New
Manulife (Manufacturers Life Insurance)
113
Manulife (Manufacturers Life Insurance)
Ontario, Canada
$28.3M -$3.92M -12,029 -12%
Mitsubishi UFJ Trust & Banking
114
Mitsubishi UFJ Trust & Banking
Japan
$28M -$8.13M -24,931 -23%
Skandinaviska Enskilda Banken (SEB)
115
Skandinaviska Enskilda Banken (SEB)
Sweden
$27.7M -$403K -1,236 -1%
Adage Capital Partners
116
Adage Capital Partners
Massachusetts
$27.5M -$64.5M -197,794 -70%
Prudential Financial
117
Prudential Financial
New Jersey
$27.4M -$28.7M -88,084 -51%
CI
118
Capital International
California
$27M +$292K +894 +1%
Axa
119
Axa
France
$26.9M -$2.01M -6,172 -7%
HSBC Holdings
120
HSBC Holdings
United Kingdom
$26.6M +$6.67M +20,483 +33%
CC
121
Casdin Capital
New York
$26.6M -$12.6M -38,500 -32%
DCM
122
Driehaus Capital Management
Illinois
$26M +$7.37M +22,586 +40%
State of Wisconsin Investment Board
123
State of Wisconsin Investment Board
Wisconsin
$25.5M +$1.61M +4,951 +7%
PAI
124
Palo Alto Investors
California
$24.6M -$2.59M -7,953 -10%
PHS
125
PFM Health Sciences
California
$23.6M -$4.87M -14,925 -17%
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