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Alnylam Pharmaceuticals

833 hedge funds and large institutions have $51.6B invested in Alnylam Pharmaceuticals in 2025 Q4 according to their latest regulatory filings, with 160 funds opening new positions, 284 increasing their positions, 290 reducing their positions, and 115 closing their positions.

New
Increased
Maintained
Reduced
Closed

more call options, than puts

Call options by funds: $ | Put options by funds: $

more first-time investments, than exits

New positions opened: | Existing positions closed:

more funds holding

Funds holding:

less ownership

Funds ownership:

2% less repeat investments, than reductions

Existing positions increased: 284 | Existing positions reduced: 290

13% less capital invested

Capital invested by funds: $59.2B → $51.6B (-$7.56B)

69% less funds holding in top 10

Funds holding in top 10: 134 (-9)

Holders
833
Holders Change
Holders Change %
% of All Funds
Holding in Top 10
4
Holding in Top 10 Change
Holding in Top 10 Change %
% of All Funds
New
Increased
Reduced
Closed
Calls
$760M
Puts
$448M
Net Calls
Net Calls Change

Top Buyers

1 +$303M
2 +$220M
3 +$158M
4
UBS Group
UBS Group
Switzerland
+$149M
5
D.E. Shaw & Co
D.E. Shaw & Co
New York
+$108M

Top Sellers

1 -$635M
2 -$383M
3 -$360M
4
Jane Street
Jane Street
New York
-$287M
5
Macquarie Group
Macquarie Group
Australia
-$276M
Name Holding Trade Value Shares
Change
Change in
Stake
RS
876
R Squared
Hong Kong
CAS
877
CTC Alternative Strategies
Illinois
FRM
878
Fox Run Management
Connecticut
FGP
879
Freestone Grove Partners
California
CIP
880
Convergence Investment Partners
Florida
QC
881
Quantedge Capital
Singapore
QCM
882
Qsemble Capital Management
New York
CWM
883
Crowley Wealth Management
Delaware
DIG
884
DeepCurrents Investment Group
New York
SCM
885
Semanteon Capital Management
Massachusetts
HI
886
HBK Investments
Texas
BCM
887
BlueCrest Capital Management
Jersey
GSC
888
Ground Swell Capital
South Carolina
NP
889
NorthRock Partners
Minnesota
SP
890
SIH Partners
Delaware
YCG
891
Yeomans Consulting Group
Georgia
PCM
892
Peregrine Capital Management
Minnesota
CCC
893
Compass Capital Corp
Massachusetts
WAM
894
Weiss Asset Management
Massachusetts
RCM
895
Requisite Capital Management
Texas
BBA
896
Baader Bank Aktiengesellschaft
Germany
KCP
897
Kera Capital Partners
California
Polen Capital Management
898
Polen Capital Management
Florida
RL
899
Retireful LLC
Michigan
SWGC
900
Summit Wealth Group (Colorado)
Colorado