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Alnylam Pharmaceuticals

839 hedge funds and large institutions have $51.7B invested in Alnylam Pharmaceuticals in 2025 Q4 according to their latest regulatory filings, with 165 funds opening new positions, 286 increasing their positions, 289 reducing their positions, and 118 closing their positions.

New
Increased
Maintained
Reduced
Closed

more call options, than puts

Call options by funds: $ | Put options by funds: $

more first-time investments, than exits

New positions opened: | Existing positions closed:

more funds holding

Funds holding:

less ownership

Funds ownership:

1% less repeat investments, than reductions

Existing positions increased: 286 | Existing positions reduced: 289

13% less capital invested

Capital invested by funds: $59.2B → $51.7B (-$7.51B)

69% less funds holding in top 10

Funds holding in top 10: 134 (-9)

Holders
839
Holders Change
Holders Change %
% of All Funds
Holding in Top 10
4
Holding in Top 10 Change
Holding in Top 10 Change %
% of All Funds
New
Increased
Reduced
Closed
Calls
$760M
Puts
$494M
Net Calls
Net Calls Change

Top Buyers

1 +$303M
2 +$220M
3 +$149M
4
D.E. Shaw & Co
D.E. Shaw & Co
New York
+$108M
5
Morgan Stanley
Morgan Stanley
New York
+$108M

Top Sellers

1 -$635M
2 -$383M
3 -$360M
4
Jane Street
Jane Street
New York
-$287M
5
Macquarie Group
Macquarie Group
Australia
-$276M
Name Holding Trade Value Shares
Change
Change in
Stake
AWA
826
Acumen Wealth Advisors
Tennessee
$796
CFD
827
Creative Financial Designs
Indiana
$795
BGA
828
Battery Global Advisors
Massachusetts
$795
CTC
829
Central Trust Company
Missouri
$553
BFS
830
Bare Financial Services
Pennsylvania
$398
DCM
831
Davis Capital Management
Florida
$398
RJA
832
Ross\Johnson & Associates
Minnesota
$398
SA
833
Seneschal Advisors
Washington
$398
FC
834
Financial Consulate
Maryland
$398
CCM
835
Chilton Capital Management
Texas
$398
HCM
836
Hollencrest Capital Management
California
$398
GEA
837
Glen Eagle Advisors
New Jersey
$398
APW
838
Atlantic Private Wealth
North Carolina
$398
MI
839
Motiv8 Investments
Florida
$3
RP
840
Regeneron Pharmaceuticals
New York
HF
841
HRT Financial
New York
SAG
842
Susquehanna Advisors Group
Pennsylvania
ACM
843
Aquatic Capital Management
Illinois
JG
844
Jain Global
New York
QC
845
Quadrature Capital
United Kingdom
Zurich Cantonal Bank
846
Zurich Cantonal Bank
Switzerland
PAI
847
Palo Alto Investors
California
ECM
848
ExodusPoint Capital Management
New York
EHI
849
Eagle Health Investments
Connecticut
AT
850
AMF Tjänstepension
Sweden