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Alnylam Pharmaceuticals

839 hedge funds and large institutions have $51.7B invested in Alnylam Pharmaceuticals in 2025 Q4 according to their latest regulatory filings, with 165 funds opening new positions, 286 increasing their positions, 289 reducing their positions, and 118 closing their positions.

New
Increased
Maintained
Reduced
Closed

more call options, than puts

Call options by funds: $ | Put options by funds: $

more first-time investments, than exits

New positions opened: | Existing positions closed:

more funds holding

Funds holding:

less ownership

Funds ownership:

1% less repeat investments, than reductions

Existing positions increased: 286 | Existing positions reduced: 289

13% less capital invested

Capital invested by funds: $59.2B → $51.7B (-$7.51B)

69% less funds holding in top 10

Funds holding in top 10: 134 (-9)

Holders
839
Holders Change
Holders Change %
% of All Funds
Holding in Top 10
4
Holding in Top 10 Change
Holding in Top 10 Change %
% of All Funds
New
Increased
Reduced
Closed
Calls
$760M
Puts
$494M
Net Calls
Net Calls Change

Top Buyers

1 +$303M
2 +$220M
3 +$149M
4
D.E. Shaw & Co
D.E. Shaw & Co
New York
+$108M
5
Morgan Stanley
Morgan Stanley
New York
+$108M

Top Sellers

1 -$635M
2 -$383M
3 -$360M
4
Jane Street
Jane Street
New York
-$287M
5
Macquarie Group
Macquarie Group
Australia
-$276M
Name Holding Trade Value Shares
Change
Change in
Stake
CTC
751
Cetera Trust Company
Minnesota
$6.36K
VWWMG
752
Vermillion & White Wealth Management Group
Pennsylvania
$6.36K
SS
753
Sunbelt Securities
Texas
$5.96K
SAM
754
Sherman Asset Management
California
$5.96K
SC
755
SouthState Corp
Florida
$5.57K
TCOV
756
Trust Company of Vermont
Vermont
$5.57K
UB
757
UMB Bank
Missouri
$5.57K
HWM
758
HighMark Wealth Management
Minnesota
$5.57K
CWIG
759
Chung Wu Investment Group
Texas
$5.17K
M
760
MOTCO
Texas
$5.17K
CFM
761
Cornerstone Financial Management
Massachusetts
$5.17K
VNA
762
Valley National Advisers
Pennsylvania
$5K
ACM
763
Accent Capital Management
Ohio
$4.77K
HFS
764
Hughes Financial Services
Virginia
$4.77K
STB
765
S&T Bank
Pennsylvania
$4.37K
FHA
766
Flagship Harbor Advisors
Massachusetts
$4.37K
CW
767
Curio Wealth
Maryland
$4.01K
TWM
768
Tripletail Wealth Management
Florida
$3.98K
MSFP
769
Mark Sheptoff Financial Planning
Connecticut
$3.98K
AIC
770
Archer Investment Corporation
Indiana
$3.98K
TFA
771
Toth Financial Advisory
Virginia
$3.98K
HIA
772
HFM Investment Advisors
New Jersey
$3.98K
HPWM
773
High Point Wealth Management
New Jersey
$3.98K
AG
774
AmeriFlex Group
Nevada
$3.58K
GBT
775
Grove Bank & Trust
Florida
$3.58K