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Alnylam Pharmaceuticals

848 hedge funds and large institutions have $51.7B invested in Alnylam Pharmaceuticals in 2025 Q4 according to their latest regulatory filings, with 170 funds opening new positions, 289 increasing their positions, 290 reducing their positions, and 118 closing their positions.

New
Increased
Maintained
Reduced
Closed

54% more call options, than puts

Call options by funds: $760M | Put options by funds: $494M

44% more first-time investments, than exits

New positions opened: 170 | Existing positions closed: 118

3% more funds holding

Funds holding: 821848 (+27)

0% less repeat investments, than reductions

Existing positions increased: 289 | Existing positions reduced: 290

0.86% less ownership

Funds ownership: 99.09%98.23% (-0.86%)

13% less capital invested

Capital invested by funds: $59.2B → $51.7B (-$7.5B)

69% less funds holding in top 10

Funds holding in top 10: 134 (-9)

Holders
848
Holders Change
+27
Holders Change %
+3.29%
% of All Funds
10.32%
Holding in Top 10
4
Holding in Top 10 Change
-9
Holding in Top 10 Change %
-69.23%
% of All Funds
0.05%
New
170
Increased
289
Reduced
290
Closed
118
Calls
$760M
Puts
$494M
Net Calls
+$266M
Net Calls Change
+$352M
Name Holding Trade Value Shares
Change
Change in
Stake
KBC Group
51
KBC Group
Belgium
$138M +$33.1M +74,842 +27%
WorldQuant Millennium Advisors
52
WorldQuant Millennium Advisors
New York
$137M +$54.3M +122,797 +56%
Sumitomo Mitsui Trust Group
53
Sumitomo Mitsui Trust Group
Japan
$130M +$5.89M +13,311 +4%
GGHC
54
Gilder Gagnon Howe & Co
New York
$127M -$4.43M -10,016 -3%
Pictet Asset Management
55
Pictet Asset Management
Switzerland
$126M -$31.6M -71,493 -18%
NAMI
56
Nomura Asset Management International
Pennsylvania
$124M +$138M +311,757 New
Jane Street
57
Jane Street
New York
$124M -$287M -647,462 -68%
Dimensional Fund Advisors
58
Dimensional Fund Advisors
Texas
$120M +$26.5M +59,931 +25%
O
59
OrbiMed
New York
$115M -$5.66M -12,800 -4%
Allspring Global Investments
60
Allspring Global Investments
North Carolina
$112M -$14.2M -32,147 -10%
Jennison Associates
61
Jennison Associates
New York
$110M -$12M -27,104 -9%
Los Angeles Capital Management
62
Los Angeles Capital Management
California
$108M +$35.7M +80,658 +51%
CAM
63
Congress Asset Management
Massachusetts
$107M +$66.6M +150,439 +127%
TD Asset Management
64
TD Asset Management
Ontario, Canada
$107M -$19.2M -43,416 -14%
Canada Pension Plan Investment Board
65
Canada Pension Plan Investment Board
Ontario, Canada
$103M +$54.2M +122,380 +90%
Wells Fargo
66
Wells Fargo
California
$102M -$10.1M -22,928 -8%
First Trust Advisors
67
First Trust Advisors
Illinois
$102M +$20.6M +46,571 +22%
Royal London Asset Management
68
Royal London Asset Management
United Kingdom
$101M -$1.88M -4,241 -2%
PCH
69
Polar Capital Holdings
United Kingdom
$95.7M -$4.8M -10,854 -4%
California Public Employees Retirement System
70
California Public Employees Retirement System
California
$94.2M +$3.26M +7,364 +3%
CS
71
Candriam SCA
Luxembourg
$89.2M +$5.27M +11,914 +6%
Barclays
72
Barclays
United Kingdom
$88.5M +$56.7M +128,153 +136%
Victory Capital Management
73
Victory Capital Management
Texas
$87.8M +$17.9M +40,517 +22%
FFM
74
FengHe Fund Management
Singapore
$87M +$96.8M +218,700 New
ProShare Advisors
75
ProShare Advisors
Maryland
$83.9M +$91.4M +206,446 +4,458%