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Alnylam Pharmaceuticals

839 hedge funds and large institutions have $51.7B invested in Alnylam Pharmaceuticals in 2025 Q4 according to their latest regulatory filings, with 165 funds opening new positions, 286 increasing their positions, 289 reducing their positions, and 118 closing their positions.

New
Increased
Maintained
Reduced
Closed

more call options, than puts

Call options by funds: $ | Put options by funds: $

more first-time investments, than exits

New positions opened: | Existing positions closed:

more funds holding

Funds holding:

less ownership

Funds ownership:

1% less repeat investments, than reductions

Existing positions increased: 286 | Existing positions reduced: 289

13% less capital invested

Capital invested by funds: $59.2B → $51.7B (-$7.51B)

69% less funds holding in top 10

Funds holding in top 10: 134 (-9)

Holders
839
Holders Change
Holders Change %
% of All Funds
Holding in Top 10
4
Holding in Top 10 Change
Holding in Top 10 Change %
% of All Funds
New
Increased
Reduced
Closed
Calls
$760M
Puts
$494M
Net Calls
Net Calls Change

Top Buyers

1 +$303M
2 +$220M
3 +$149M
4
D.E. Shaw & Co
D.E. Shaw & Co
New York
+$108M
5
Morgan Stanley
Morgan Stanley
New York
+$108M

Top Sellers

1 -$635M
2 -$383M
3 -$360M
4
Jane Street
Jane Street
New York
-$287M
5
Macquarie Group
Macquarie Group
Australia
-$276M
Name Holding Trade Value Shares
Change
Change in
Stake
SC
676
Steph & Co
Wisconsin
$53.7K
BLC
677
Brown, Lisle/Cummings
Rhode Island
$52.5K
Fifth Third Bancorp
678
Fifth Third Bancorp
Ohio
$50.5K
PPC
679
Park Place Capital
Alabama
$50.1K
FAMI
680
Fideuram Asset Management (Ireland)
$49.8K
RF
681
Rossby Financial
Florida
$49.3K
HI
682
Harbour Investments
Wisconsin
$46.1K
SWM
683
SHP Wealth Management
Massachusetts
$43.2K
AWM
684
Activest Wealth Management
Florida
$42.9K
TW
685
Titan Wealth
$41.8K
LSA
686
Leonteq Securities AG
Switzerland
$41.8K
EB
687
Eastern Bank
Massachusetts
$41.8K
KFAS
688
Keating Financial Advisory Services
Kansas
$41.4K
HNB
689
Huntington National Bank
Ohio
$40.6K
HFM
690
Hartford Financial Management
Connecticut
$39.8K
CT
691
Colonial Trust
South Carolina
$39.4K
PFBT
692
Parkside Financial Bank & Trust
Missouri
$38.6K
EC
693
Elequin Capital
New York
$38.6K
WIM
694
Westside Investment Management
California
$38.4K
QC
695
Quent Capital
New York
$37.4K
MCM
696
Manchester Capital Management
Vermont
$33.4K
WTC
697
WhitTier Trust Company
Nevada
$33.3K
CPG
698
Cornerstone Planning Group
New Jersey
$33.2K
HNB
699
Hilltop National Bank
Wyoming
$31.8K
OP
700
ORG Partners
Indiana
$29K