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Alnylam Pharmaceuticals

833 hedge funds and large institutions have $51.6B invested in Alnylam Pharmaceuticals in 2025 Q4 according to their latest regulatory filings, with 160 funds opening new positions, 284 increasing their positions, 290 reducing their positions, and 115 closing their positions.

New
Increased
Maintained
Reduced
Closed

more call options, than puts

Call options by funds: $ | Put options by funds: $

more first-time investments, than exits

New positions opened: | Existing positions closed:

more funds holding

Funds holding:

less ownership

Funds ownership:

2% less repeat investments, than reductions

Existing positions increased: 284 | Existing positions reduced: 290

13% less capital invested

Capital invested by funds: $59.2B → $51.6B (-$7.56B)

69% less funds holding in top 10

Funds holding in top 10: 134 (-9)

Holders
833
Holders Change
Holders Change %
% of All Funds
Holding in Top 10
4
Holding in Top 10 Change
Holding in Top 10 Change %
% of All Funds
New
Increased
Reduced
Closed
Calls
$760M
Puts
$448M
Net Calls
Net Calls Change

Top Buyers

1 +$303M
2 +$220M
3 +$158M
4
UBS Group
UBS Group
Switzerland
+$149M
5
D.E. Shaw & Co
D.E. Shaw & Co
New York
+$108M

Top Sellers

1 -$635M
2 -$383M
3 -$360M
4
Jane Street
Jane Street
New York
-$287M
5
Macquarie Group
Macquarie Group
Australia
-$276M
Name Holding Trade Value Shares
Change
Change in
Stake
Fifth Third Bancorp
676
Fifth Third Bancorp
Ohio
$50.5K
PPC
677
Park Place Capital
Alabama
$50.1K
FAMI
678
Fideuram Asset Management (Ireland)
$49.8K
RF
679
Rossby Financial
Florida
$49.3K
HI
680
Harbour Investments
Wisconsin
$46.1K
AWM
681
Activest Wealth Management
Florida
$42.9K
TW
682
Titan Wealth
$41.8K
LSA
683
Leonteq Securities AG
Switzerland
$41.8K
EB
684
Eastern Bank
Massachusetts
$41.8K
KFAS
685
Keating Financial Advisory Services
Kansas
$41.4K
HNB
686
Huntington National Bank
Ohio
$40.6K
HFM
687
Hartford Financial Management
Connecticut
$39.8K
CT
688
Colonial Trust
South Carolina
$39.4K
PFBT
689
Parkside Financial Bank & Trust
Missouri
$38.6K
EC
690
Elequin Capital
New York
$38.6K
WIM
691
Westside Investment Management
California
$38.4K
QC
692
Quent Capital
New York
$37.4K
MCM
693
Manchester Capital Management
Vermont
$33.4K
WTC
694
WhitTier Trust Company
Nevada
$33.3K
CPG
695
Cornerstone Planning Group
New Jersey
$33.2K
HNB
696
Hilltop National Bank
Wyoming
$31.8K
OP
697
ORG Partners
Indiana
$29K
TFM
698
TFC Financial Management
Massachusetts
$28.6K
GSWM
699
Golden State Wealth Management
California
$28.6K
WT
700
Whittier Trust
California
$28K