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Alnylam Pharmaceuticals

833 hedge funds and large institutions have $51.6B invested in Alnylam Pharmaceuticals in 2025 Q4 according to their latest regulatory filings, with 160 funds opening new positions, 284 increasing their positions, 290 reducing their positions, and 115 closing their positions.

New
Increased
Maintained
Reduced
Closed

more call options, than puts

Call options by funds: $ | Put options by funds: $

more first-time investments, than exits

New positions opened: | Existing positions closed:

more funds holding

Funds holding:

less ownership

Funds ownership:

2% less repeat investments, than reductions

Existing positions increased: 284 | Existing positions reduced: 290

13% less capital invested

Capital invested by funds: $59.2B → $51.6B (-$7.56B)

69% less funds holding in top 10

Funds holding in top 10: 134 (-9)

Holders
833
Holders Change
Holders Change %
% of All Funds
Holding in Top 10
4
Holding in Top 10 Change
Holding in Top 10 Change %
% of All Funds
New
Increased
Reduced
Closed
Calls
$760M
Puts
$448M
Net Calls
Net Calls Change

Top Buyers

1 +$303M
2 +$220M
3 +$158M
4
UBS Group
UBS Group
Switzerland
+$149M
5
D.E. Shaw & Co
D.E. Shaw & Co
New York
+$108M

Top Sellers

1 -$635M
2 -$383M
3 -$360M
4
Jane Street
Jane Street
New York
-$287M
5
Macquarie Group
Macquarie Group
Australia
-$276M
Name Holding Trade Value Shares
Change
Change in
Stake
TFIPS
626
Towarzystwo Funduszy Inwestycyjnych PZU SA
$211K
SIA
627
Soltis Investment Advisors
Utah
$211K
AC
628
AlphaCore Capital
California
$210K
AWM
629
Ariadne Wealth Management
California
$209K
GS
630
GTS Securities
New York
$209K
CFP
631
Cascade Financial Partners
California
$208K
FFO
632
Fortitude Family Office
Arizona
$206K
OIA
633
OneDigital Investment Advisors
Kansas
$203K
PA
634
PharVision Advisers
Florida
$200K
PCTC
635
Perkins Coie Trust Company
Washington
$199K
HI
636
Horizon Investments
North Carolina
$179K
MCM
637
MAI Capital Management
Ohio
$178K
UFF
638
USA Financial Formulas
Michigan
$169K
VCM
639
Versant Capital Management
Arizona
$165K
BC
640
Bayforest Capital
United Kingdom
$164K
SAG
641
SageView Advisory Group
California
$158K
RIL
642
Rothschild Investment LLC
Illinois
$143K
QT
643
Quantbot Technologies
New York
$139K
GC
644
Globeflex Capital
California
$133K
EFMH
645
E Fund Management (HK)
Hong Kong
$132K
TWC
646
TD Waterhouse Canada
Ontario, Canada
$131K
HP
647
Havemeyer Place
Connecticut
$119K
BTI
648
Blue Trust Inc
Georgia
$113K
MR
649
Munich Reinsurance
$109K
GWM
650
Greenline Wealth Management
Florida
$96.1K