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Alnylam Pharmaceuticals

833 hedge funds and large institutions have $51.6B invested in Alnylam Pharmaceuticals in 2025 Q4 according to their latest regulatory filings, with 160 funds opening new positions, 284 increasing their positions, 290 reducing their positions, and 115 closing their positions.

New
Increased
Maintained
Reduced
Closed

more call options, than puts

Call options by funds: $ | Put options by funds: $

more first-time investments, than exits

New positions opened: | Existing positions closed:

more funds holding

Funds holding:

less ownership

Funds ownership:

2% less repeat investments, than reductions

Existing positions increased: 284 | Existing positions reduced: 290

13% less capital invested

Capital invested by funds: $59.2B → $51.6B (-$7.56B)

69% less funds holding in top 10

Funds holding in top 10: 134 (-9)

Holders
833
Holders Change
Holders Change %
% of All Funds
Holding in Top 10
4
Holding in Top 10 Change
Holding in Top 10 Change %
% of All Funds
New
Increased
Reduced
Closed
Calls
$760M
Puts
$448M
Net Calls
Net Calls Change

Top Buyers

1 +$303M
2 +$220M
3 +$158M
4
UBS Group
UBS Group
Switzerland
+$149M
5
D.E. Shaw & Co
D.E. Shaw & Co
New York
+$108M

Top Sellers

1 -$635M
2 -$383M
3 -$360M
4
Jane Street
Jane Street
New York
-$287M
5
Macquarie Group
Macquarie Group
Australia
-$276M
Name Holding Trade Value Shares
Change
Change in
Stake
IAA
601
Independent Advisor Alliance
North Carolina
$241K
WC
602
Waterloo Capital
Texas
$241K
PE
603
PCM Encore
Colorado
$240K
CP
604
Covenant Partners
Tennessee
$240K
LWM
605
LeConte Wealth Management
Tennessee
$240K
AG
606
AlTi Global
New York
$239K
EWM
607
Evercore Wealth Management
New York
$239K
PPWP
608
Premier Path Wealth Partners
New Jersey
$237K
GCM
609
Graham Capital Management
Connecticut
$234K
LA
610
LVW Advisors
New York
$231K
Northwestern Mutual Wealth Management
611
Northwestern Mutual Wealth Management
Wisconsin
$231K
AG
612
Algert Global
California
$231K
CFG
613
Cooper Financial Group
California
$231K
KWA
614
Kingswood Wealth Advisors
California
$228K
OCBCO
615
Oversea-Chinese Banking Corp (OCBC)
Singapore
$225K
NWM
616
Northwest Wealth Management
Iowa
$225K
FCP
617
Fidelis Capital Partners
Florida
$224K
AA
618
Alta Advisers
United Kingdom
$221K
CPIG
619
Chicago Partners Investment Group
Illinois
$221K
GF
620
Gabelli Funds
New York
$219K
PWG
621
Portside Wealth Group
Utah
$217K
EL
622
Essex LLC
Illinois
$217K
CPA
623
Capital Performance Advisors
California
$215K
FFA
624
Fi3 Financial Advisors
Indiana
$214K
IB
625
Intrust Bank
Kansas
$214K