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Alnylam Pharmaceuticals

839 hedge funds and large institutions have $51.7B invested in Alnylam Pharmaceuticals in 2025 Q4 according to their latest regulatory filings, with 165 funds opening new positions, 286 increasing their positions, 289 reducing their positions, and 118 closing their positions.

New
Increased
Maintained
Reduced
Closed

more call options, than puts

Call options by funds: $ | Put options by funds: $

more first-time investments, than exits

New positions opened: | Existing positions closed:

more funds holding

Funds holding:

less ownership

Funds ownership:

1% less repeat investments, than reductions

Existing positions increased: 286 | Existing positions reduced: 289

13% less capital invested

Capital invested by funds: $59.2B → $51.7B (-$7.51B)

69% less funds holding in top 10

Funds holding in top 10: 134 (-9)

Holders
839
Holders Change
Holders Change %
% of All Funds
Holding in Top 10
4
Holding in Top 10 Change
Holding in Top 10 Change %
% of All Funds
New
Increased
Reduced
Closed
Calls
$760M
Puts
$494M
Net Calls
Net Calls Change

Top Buyers

1 +$303M
2 +$220M
3 +$149M
4
D.E. Shaw & Co
D.E. Shaw & Co
New York
+$108M
5
Morgan Stanley
Morgan Stanley
New York
+$108M

Top Sellers

1 -$635M
2 -$383M
3 -$360M
4
Jane Street
Jane Street
New York
-$287M
5
Macquarie Group
Macquarie Group
Australia
-$276M
Name Holding Trade Value Shares
Change
Change in
Stake
QCG
601
Quadrant Capital Group
Ohio
$245K
IAA
602
Independent Advisor Alliance
North Carolina
$241K
WC
603
Waterloo Capital
Texas
$241K
PE
604
PCM Encore
Colorado
$240K
CP
605
Covenant Partners
Tennessee
$240K
LWM
606
LeConte Wealth Management
Tennessee
$240K
AG
607
AlTi Global
New York
$239K
EWM
608
Evercore Wealth Management
New York
$239K
PPWP
609
Premier Path Wealth Partners
New Jersey
$237K
GCM
610
Graham Capital Management
Connecticut
$234K
LA
611
LVW Advisors
New York
$231K
Northwestern Mutual Wealth Management
612
Northwestern Mutual Wealth Management
Wisconsin
$231K
AG
613
Algert Global
California
$231K
CFG
614
Cooper Financial Group
California
$231K
KWA
615
Kingswood Wealth Advisors
California
$228K
OCBCO
616
Oversea-Chinese Banking Corp (OCBC)
Singapore
$225K
NWM
617
Northwest Wealth Management
Iowa
$225K
FCP
618
Fidelis Capital Partners
Florida
$224K
AA
619
Alta Advisers
United Kingdom
$221K
CPIG
620
Chicago Partners Investment Group
Illinois
$221K
GF
621
Gabelli Funds
New York
$219K
PWG
622
Portside Wealth Group
Utah
$217K
EL
623
Essex LLC
Illinois
$217K
CPA
624
Capital Performance Advisors
California
$215K
FFA
625
Fi3 Financial Advisors
Indiana
$214K