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Alnylam Pharmaceuticals

839 hedge funds and large institutions have $51.7B invested in Alnylam Pharmaceuticals in 2025 Q4 according to their latest regulatory filings, with 165 funds opening new positions, 286 increasing their positions, 289 reducing their positions, and 118 closing their positions.

New
Increased
Maintained
Reduced
Closed

more call options, than puts

Call options by funds: $ | Put options by funds: $

more first-time investments, than exits

New positions opened: | Existing positions closed:

more funds holding

Funds holding:

less ownership

Funds ownership:

1% less repeat investments, than reductions

Existing positions increased: 286 | Existing positions reduced: 289

13% less capital invested

Capital invested by funds: $59.2B → $51.7B (-$7.51B)

69% less funds holding in top 10

Funds holding in top 10: 134 (-9)

Holders
839
Holders Change
Holders Change %
% of All Funds
Holding in Top 10
4
Holding in Top 10 Change
Holding in Top 10 Change %
% of All Funds
New
Increased
Reduced
Closed
Calls
$760M
Puts
$494M
Net Calls
Net Calls Change

Top Buyers

1 +$303M
2 +$220M
3 +$149M
4
D.E. Shaw & Co
D.E. Shaw & Co
New York
+$108M
5
Morgan Stanley
Morgan Stanley
New York
+$108M

Top Sellers

1 -$635M
2 -$383M
3 -$360M
4
Jane Street
Jane Street
New York
-$287M
5
Macquarie Group
Macquarie Group
Australia
-$276M
Name Holding Trade Value Shares
Change
Change in
Stake
SFC
576
SYM Financial Corp
Indiana
$290K
MF
577
Meridian Financial
Massachusetts
$289K
PWP
578
Perfromance Wealth Partners
Illinois
$288K
OIAM
579
OFI Invest Asset Management
France
$281K
BFS
580
Bradley Foster & Sargent
Connecticut
$279K
G
581
GenTrust
Florida
$276K
EFS
582
Essex Financial Services
Connecticut
$274K
DWM
583
Dynasty Wealth Management
Florida
$274K
ATS
584
Ashton Thomas Securities
New York
$274K
FT
585
Fiduciary Trust
Massachusetts
$270K
AAP
586
Arax Advisory Partners
Colorado
$270K
SRL
587
Scientech Research LLC
New Jersey
$269K
GT
588
Glenmede Trust
Pennsylvania
$268K
SAI
589
Savvy Advisors Inc
New York
$267K
EWA
590
EP Wealth Advisors
California
$267K
LAM
591
L2 Asset Management
Massachusetts
$267K
LWAM
592
Legacy Wealth Asset Management
Minnesota
$266K
IA
593
IFP Advisors
Florida
$264K
BIG
594
Brooklyn Investment Group
New York
$258K
WFI
595
West Family Investments
California
$257K
SFS
596
Sowell Financial Services
Arkansas
$256K
PMFA
597
Plante Moran Financial Advisors
Michigan
$253K
EW
598
Evoke Wealth
California
$247K
TCA
599
Transcend Capital Advisors
New Jersey
$247K
EA
600
Everpar Advisors
Oklahoma
$247K