ALNY icon

Alnylam Pharmaceuticals

839 hedge funds and large institutions have $51.7B invested in Alnylam Pharmaceuticals in 2025 Q4 according to their latest regulatory filings, with 165 funds opening new positions, 286 increasing their positions, 289 reducing their positions, and 118 closing their positions.

New
Increased
Maintained
Reduced
Closed

more call options, than puts

Call options by funds: $ | Put options by funds: $

more first-time investments, than exits

New positions opened: | Existing positions closed:

more funds holding

Funds holding:

less ownership

Funds ownership:

1% less repeat investments, than reductions

Existing positions increased: 286 | Existing positions reduced: 289

13% less capital invested

Capital invested by funds: $59.2B → $51.7B (-$7.51B)

69% less funds holding in top 10

Funds holding in top 10: 134 (-9)

Holders
839
Holders Change
Holders Change %
% of All Funds
Holding in Top 10
4
Holding in Top 10 Change
Holding in Top 10 Change %
% of All Funds
New
Increased
Reduced
Closed
Calls
$760M
Puts
$494M
Net Calls
Net Calls Change

Top Buyers

1 +$303M
2 +$220M
3 +$149M
4
D.E. Shaw & Co
D.E. Shaw & Co
New York
+$108M
5
Morgan Stanley
Morgan Stanley
New York
+$108M

Top Sellers

1 -$635M
2 -$383M
3 -$360M
4
Jane Street
Jane Street
New York
-$287M
5
Macquarie Group
Macquarie Group
Australia
-$276M
Name Holding Trade Value Shares
Change
Change in
Stake
NPA
526
Nichols & Pratt Advisers
Massachusetts
$413K
ECA
527
Elevate Capital Advisors
Colorado
$413K
ALAM
528
Asahi Life Asset Management
Japan
$411K
WA
529
Waddell & Associates
Tennessee
$404K
BCG
530
Breakwater Capital Group
New Jersey
$400K
PPW
531
Parcion Private Wealth
Washington
$398K
Calamos Advisors
532
Calamos Advisors
Illinois
$398K
WP
533
Westmount Partners
California
$398K
LS
534
Livforsakringsbolaget Skandia
Sweden
$398K
CG
535
Caprock Group
Idaho
$394K
OC
536
Oppenheimer & Co
New York
$384K
GIM
537
Generali Investments Management
Slovenia
$384K
ORG
538
Optimist Retirement Group
Washington
$383K
CG
539
Cynosure Group
Utah
$378K
OAM
540
Ostrum Asset Management
France
$377K
AWA
541
Aaron Wealth Advisors
Illinois
$371K
PMAM
542
Picton Mahoney Asset Management
Ontario, Canada
$371K
PCM
543
Prelude Capital Management
New York
$369K
TP
544
Thayer Partners
Pennsylvania
$369K
HWA
545
HCR Wealth Advisors
California
$367K
DO
546
denkapparat Operations
Germany
$363K
AFG
547
Atomi Financial Group
New York
$361K
WWC
548
Waypoint Wealth Counsel
Georgia
$356K
GI
549
GAMMA Investing
California
$355K
BFIM
550
Beese Fulmer Investment Management
Ohio
$353K