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Alnylam Pharmaceuticals

833 hedge funds and large institutions have $51.6B invested in Alnylam Pharmaceuticals in 2025 Q4 according to their latest regulatory filings, with 160 funds opening new positions, 284 increasing their positions, 290 reducing their positions, and 115 closing their positions.

New
Increased
Maintained
Reduced
Closed

more call options, than puts

Call options by funds: $ | Put options by funds: $

more first-time investments, than exits

New positions opened: | Existing positions closed:

more funds holding

Funds holding:

less ownership

Funds ownership:

2% less repeat investments, than reductions

Existing positions increased: 284 | Existing positions reduced: 290

13% less capital invested

Capital invested by funds: $59.2B → $51.6B (-$7.56B)

69% less funds holding in top 10

Funds holding in top 10: 134 (-9)

Holders
833
Holders Change
Holders Change %
% of All Funds
Holding in Top 10
4
Holding in Top 10 Change
Holding in Top 10 Change %
% of All Funds
New
Increased
Reduced
Closed
Calls
$760M
Puts
$448M
Net Calls
Net Calls Change

Top Buyers

1 +$303M
2 +$220M
3 +$158M
4
UBS Group
UBS Group
Switzerland
+$149M
5
D.E. Shaw & Co
D.E. Shaw & Co
New York
+$108M

Top Sellers

1 -$635M
2 -$383M
3 -$360M
4
Jane Street
Jane Street
New York
-$287M
5
Macquarie Group
Macquarie Group
Australia
-$276M
Name Holding Trade Value Shares
Change
Change in
Stake
ECA
526
Elevate Capital Advisors
Colorado
$413K
ALAM
527
Asahi Life Asset Management
Japan
$411K
WA
528
Waddell & Associates
Tennessee
$404K
BCG
529
Breakwater Capital Group
New Jersey
$400K
PPW
530
Parcion Private Wealth
Washington
$398K
Calamos Advisors
531
Calamos Advisors
Illinois
$398K
WP
532
Westmount Partners
California
$398K
LS
533
Livforsakringsbolaget Skandia
Sweden
$398K
CG
534
Caprock Group
Idaho
$394K
OC
535
Oppenheimer & Co
New York
$384K
GIM
536
Generali Investments Management
Slovenia
$384K
ORG
537
Optimist Retirement Group
Washington
$383K
CG
538
Cynosure Group
Utah
$378K
OAM
539
Ostrum Asset Management
France
$377K
AWA
540
Aaron Wealth Advisors
Illinois
$371K
PMAM
541
Picton Mahoney Asset Management
Ontario, Canada
$371K
PCM
542
Prelude Capital Management
New York
$369K
TP
543
Thayer Partners
Pennsylvania
$369K
HWA
544
HCR Wealth Advisors
California
$367K
DO
545
denkapparat Operations
Germany
$363K
AFG
546
Atomi Financial Group
New York
$361K
WWC
547
Waypoint Wealth Counsel
Georgia
$356K
GI
548
GAMMA Investing
California
$355K
BFIM
549
Beese Fulmer Investment Management
Ohio
$353K
SC
550
Savant Capital
Illinois
$348K