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Alnylam Pharmaceuticals

846 hedge funds and large institutions have $51.7B invested in Alnylam Pharmaceuticals in 2025 Q4 according to their latest regulatory filings, with 169 funds opening new positions, 288 increasing their positions, 290 reducing their positions, and 118 closing their positions.

New
Increased
Maintained
Reduced
Closed

more call options, than puts

Call options by funds: $ | Put options by funds: $

more first-time investments, than exits

New positions opened: | Existing positions closed:

more funds holding

Funds holding:

less repeat investments, than reductions

Existing positions increased: | Existing positions reduced:

0.83% less ownership

Funds ownership: 99.03%98.2% (-0.83%)

13% less capital invested

Capital invested by funds: $59.2B → $51.7B (-$7.48B)

69% less funds holding in top 10

Funds holding in top 10: 134 (-9)

Holders
846
Holders Change
Holders Change %
% of All Funds
Holding in Top 10
4
Holding in Top 10 Change
Holding in Top 10 Change %
% of All Funds
New
Increased
Reduced
Closed
Calls
$760M
Puts
$494M
Net Calls
Net Calls Change

Top Buyers

1 +$303M
2 +$220M
3 +$149M
4
D.E. Shaw & Co
D.E. Shaw & Co
New York
+$108M
5
Morgan Stanley
Morgan Stanley
New York
+$108M

Top Sellers

1 -$635M
2 -$383M
3 -$360M
4
Jane Street
Jane Street
New York
-$287M
5
Macquarie Group
Macquarie Group
Australia
-$276M
Name Holding Trade Value Shares
Change
Change in
Stake
CBA
526
Coastal Bridge Advisors
Connecticut
$417K
PCG
527
Prosperity Consulting Group
Maryland
$414K
NPA
528
Nichols & Pratt Advisers
Massachusetts
$413K
ECA
529
Elevate Capital Advisors
Colorado
$413K
ALAM
530
Asahi Life Asset Management
Japan
$411K
WA
531
Waddell & Associates
Tennessee
$404K
BCG
532
Breakwater Capital Group
New Jersey
$400K
PPW
533
Parcion Private Wealth
Washington
$398K
Calamos Advisors
534
Calamos Advisors
Illinois
$398K
WP
535
Westmount Partners
California
$398K
LS
536
Livforsakringsbolaget Skandia
Sweden
$398K
CG
537
Caprock Group
Idaho
$394K
OC
538
Oppenheimer & Co
New York
$384K
GIM
539
Generali Investments Management
Slovenia
$384K
ORG
540
Optimist Retirement Group
Washington
$383K
CG
541
Cynosure Group
Utah
$378K
OAM
542
Ostrum Asset Management
France
$377K
AWA
543
Aaron Wealth Advisors
Illinois
$371K
PMAM
544
Picton Mahoney Asset Management
Ontario, Canada
$371K
PCM
545
Prelude Capital Management
New York
$369K
TP
546
Thayer Partners
Pennsylvania
$369K
HWA
547
HCR Wealth Advisors
California
$367K
DO
548
denkapparat Operations
Germany
$363K
AFG
549
Atomi Financial Group
New York
$361K
WWC
550
Waypoint Wealth Counsel
Georgia
$356K