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Alnylam Pharmaceuticals

833 hedge funds and large institutions have $51.6B invested in Alnylam Pharmaceuticals in 2025 Q4 according to their latest regulatory filings, with 160 funds opening new positions, 284 increasing their positions, 290 reducing their positions, and 115 closing their positions.

New
Increased
Maintained
Reduced
Closed

more call options, than puts

Call options by funds: $ | Put options by funds: $

more first-time investments, than exits

New positions opened: | Existing positions closed:

more funds holding

Funds holding:

less ownership

Funds ownership:

2% less repeat investments, than reductions

Existing positions increased: 284 | Existing positions reduced: 290

13% less capital invested

Capital invested by funds: $59.2B → $51.6B (-$7.56B)

69% less funds holding in top 10

Funds holding in top 10: 134 (-9)

Holders
833
Holders Change
Holders Change %
% of All Funds
Holding in Top 10
4
Holding in Top 10 Change
Holding in Top 10 Change %
% of All Funds
New
Increased
Reduced
Closed
Calls
$760M
Puts
$448M
Net Calls
Net Calls Change

Top Buyers

1 +$303M
2 +$220M
3 +$158M
4
UBS Group
UBS Group
Switzerland
+$149M
5
D.E. Shaw & Co
D.E. Shaw & Co
New York
+$108M

Top Sellers

1 -$635M
2 -$383M
3 -$360M
4
Jane Street
Jane Street
New York
-$287M
5
Macquarie Group
Macquarie Group
Australia
-$276M
Name Holding Trade Value Shares
Change
Change in
Stake
FRA
501
Frank Rimerman Advisors
California
$497K
PFPG
502
Pinnacle Financial Partners (Georgia)
Georgia
$492K
FFA
503
Farther Finance Advisors
California
$491K
CI
504
Cigna Investments
Connecticut
$490K
BIM
505
Bridges Investment Management
Nebraska
$484K
SAM
506
Smartleaf Asset Management
Massachusetts
$478K
NG
507
Norden Group
Utah
$473K
WPC
508
Wedmont Private Capital
Pennsylvania
$470K
CIA
509
Caerus Investment Advisors
Texas
$466K
MC
510
Mathes Company
New York
$459K
LAM
511
LECAP Asset Management
United Kingdom
$458K
HH
512
Hilltop Holdings
Texas
$453K
SWP
513
Sagespring Wealth Partners
Tennessee
$452K
FTUS
514
Flow Traders U.S.
New York
$451K
TAA
515
TB Alternative Assets
Cayman Islands
$451K
BPC
516
Banque Pictet & Cie
Switzerland
$445K
AHL
517
Abel Hall LLC
Louisiana
$442K
SAM
518
Simplify Asset Management
Nevada
$441K
NSAM
519
North Star Asset Management
Wisconsin
$439K
CGPCS
520
Capital Group Private Client Services
California
$425K
EWA
521
EverSource Wealth Advisors
Alabama
$422K
SL
522
Sentinus LLC
Illinois
$418K
CBA
523
Coastal Bridge Advisors
Connecticut
$417K
PCG
524
Prosperity Consulting Group
Maryland
$414K
NPA
525
Nichols & Pratt Advisers
Massachusetts
$413K