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Alnylam Pharmaceuticals

848 hedge funds and large institutions have $51.7B invested in Alnylam Pharmaceuticals in 2025 Q4 according to their latest regulatory filings, with 170 funds opening new positions, 289 increasing their positions, 290 reducing their positions, and 118 closing their positions.

New
Increased
Maintained
Reduced
Closed

54% more call options, than puts

Call options by funds: $760M | Put options by funds: $494M

44% more first-time investments, than exits

New positions opened: 170 | Existing positions closed: 118

3% more funds holding

Funds holding: 821848 (+27)

0% less repeat investments, than reductions

Existing positions increased: 289 | Existing positions reduced: 290

0.86% less ownership

Funds ownership: 99.09%98.23% (-0.86%)

13% less capital invested

Capital invested by funds: $59.2B → $51.7B (-$7.5B)

69% less funds holding in top 10

Funds holding in top 10: 134 (-9)

Holders
848
Holders Change
+27
Holders Change %
+3.29%
% of All Funds
10.32%
Holding in Top 10
4
Holding in Top 10 Change
-9
Holding in Top 10 Change %
-69.23%
% of All Funds
0.05%
New
170
Increased
289
Reduced
290
Closed
118
Calls
$760M
Puts
$494M
Net Calls
+$266M
Net Calls Change
+$352M
Name Holding Trade Value Shares
Change
Change in
Stake
Qube Research & Technologies (QRT)
26
Qube Research & Technologies (QRT)
United Kingdom
$308M -$16.2M -36,602 -5%
Deutsche Bank
27
Deutsche Bank
Germany
$283M +$46.8M +105,655 +17%
Bank of America
28
Bank of America
North Carolina
$272M -$360M -813,314 -54%
UBS AM
29
UBS AM
Illinois
$259M -$24.9M -56,198 -8%
Charles Schwab
30
Charles Schwab
California
$258M +$12.9M +29,069 +5%
Federated Hermes
31
Federated Hermes
Pennsylvania
$250M +$34.5M +77,959 +14%
Two Sigma Investments
32
Two Sigma Investments
New York
$245M +$8.94M +20,194 +3%
Amundi
33
Amundi
France
$242M +$99.4M +224,607 +58%
ClearBridge Investments
34
ClearBridge Investments
New York
$237M -$11.3M -25,422 -4%
Royal Bank of Canada
35
Royal Bank of Canada
Ontario, Canada
$235M +$68.5M +154,737 +35%
N
36
Nuveen
North Carolina
$225M -$9.75M -22,032 -4%
Marshall Wace
37
Marshall Wace
United Kingdom
$219M +$18.4M +41,551 +8%
Bank of New York Mellon
38
Bank of New York Mellon
New York
$200M +$37.3M +84,350 +20%
AF
39
Align Financial
Minnesota
$199M +$88M +198,825 New
Massachusetts Financial Services
40
Massachusetts Financial Services
Massachusetts
$197M +$61.4M +138,778 +39%
Loomis, Sayles & Company
41
Loomis, Sayles & Company
Massachusetts
$194M -$5.21M -11,775 -2%
BG
42
Bellevue Group
Switzerland
$177M -$275K -621 -0.1%
D.E. Shaw & Co
43
D.E. Shaw & Co
New York
$177M +$108M +245,076 +123%
1832 Asset Management
44
1832 Asset Management
Ontario, Canada
$175M -$8.5M -19,200 -4%
Jacobs Levy Equity Management
45
Jacobs Levy Equity Management
New Jersey
$160M -$3.97M -8,971 -2%
BNP Paribas Financial Markets
46
BNP Paribas Financial Markets
France
$155M +$105M +236,396 +154%
Raymond James Financial
47
Raymond James Financial
Florida
$154M +$5.05M +11,411 +3%
Goldman Sachs
48
Goldman Sachs
New York
$149M -$72.1M -163,023 -30%
Swiss National Bank
49
Swiss National Bank
Switzerland
$143M -$7.35M -16,600 -4%
Squarepoint
50
Squarepoint
New York
$140M +$90.9M +205,404 +141%