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Alnylam Pharmaceuticals
ALNY

Overview Fund Activity

646 hedge funds and large institutions have $43B invested in Alnylam Pharmaceuticals in 2025 Q2 according to their latest regulatory filings, with 97 funds opening new positions, 257 increasing their positions, 214 reducing their positions, and 62 closing their positions.

New
Increased
Maintained
Reduced
Closed
Holders
646
Holders Change
+29
Holders Change %
+4.7%
% of All Funds
8.66%
Holding in Top 10
9
Holding in Top 10 Change
-1
Holding in Top 10 Change %
-10%
% of All Funds
0.12%
New
97
Increased
257
Reduced
214
Closed
62
Calls
$188M
Puts
$203M
Net Calls
-$15.5M
Net Calls Change
-$50.8M

Top Buyers

1
Citadel Advisors
Citadel Advisors
Florida
+$195M
2
Holocene Advisors
Holocene Advisors
New York
+$195M
3
ClearBridge Investments
ClearBridge Investments
New York
+$179M
4
Macquarie Group
Macquarie Group
Australia
+$172M
5
Fidelity Investments
Fidelity Investments
Massachusetts
+$162M

Top Sellers

1
AQR Capital Management
AQR Capital Management
Connecticut
-$208M
2
Baillie Gifford & Co
Baillie Gifford & Co
United Kingdom
-$204M
3
Wellington Management Group
Wellington Management Group
Massachusetts
-$175M
4
T. Rowe Price Associates
T. Rowe Price Associates
Maryland
-$117M
5
Qube Research & Technologies (QRT)
Qube Research & Technologies (QRT)
United Kingdom
-$89.2M
Name Holding Trade Value Shares
Change 		Shares
Change %
BG
26
Bellevue Group
Switzerland
$221M -$29.9M -91,780 -12%
Deutsche Bank
27
Deutsche Bank
Germany
$212M +$23.6M +72,291 +13%
WP
28
Woodline Partners
California
$203M +$152M +466,651 +298%
Franklin Resources
29
Franklin Resources
California
$196M +$46.6M +143,017 +31%
Citadel Advisors
30
Citadel Advisors
Florida
$196M +$195M +596,963 +14,093%
Macquarie Group
31
Macquarie Group
Australia
$196M +$172M +527,519 +727%
Holocene Advisors
32
Holocene Advisors
New York
$195M +$195M +596,816 New
Charles Schwab
33
Charles Schwab
California
$186M +$5.59M +17,141 +3%
ClearBridge Investments
34
ClearBridge Investments
New York
$182M +$179M +549,322 +7,063%
Goldman Sachs
35
Goldman Sachs
New York
$178M +$39.8M +121,949 +29%
UBS Group
36
UBS Group
Switzerland
$177M +$86.4M +264,848 +95%
Loomis, Sayles & Company
37
Loomis, Sayles & Company
Massachusetts
$159M -$3.31M -10,156 -2%
Pictet Asset Management
38
Pictet Asset Management
Switzerland
$151M -$5.32M -16,361 -3%
TD Asset Management
39
TD Asset Management
Ontario, Canada
$144M -$14.8M -45,407 -9%
Royal Bank of Canada
40
Royal Bank of Canada
Ontario, Canada
$140M +$30.5M +93,604 +28%
Bank of New York Mellon
41
Bank of New York Mellon
New York
$140M -$14.7M -45,063 -9%
Amundi
42
Amundi
France
$130M -$20.1M -60,816 -13%
Swiss National Bank
43
Swiss National Bank
Switzerland
$128M +$9.65M +29,600 +8%
Jennison Associates
44
Jennison Associates
New York
$114M +$13.3M +40,851 +13%
Two Sigma Investments
45
Two Sigma Investments
New York
$112M +$47.6M +145,890 +74%
O
46
OrbiMed
New York
$111M -$1.37M -4,200 -1%
GGHC
47
Gilder Gagnon Howe & Co
New York
$110M -$2.77M -8,487 -2%
Federated Hermes
48
Federated Hermes
Pennsylvania
$106M +$19.5M +59,669 +23%
Wells Fargo
49
Wells Fargo
California
$105M +$7.09M +21,744 +7%
SEI Investments
50
SEI Investments
Pennsylvania
$101M +$10.2M +31,250 +11%
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