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Alnylam Pharmaceuticals

839 hedge funds and large institutions have $51.7B invested in Alnylam Pharmaceuticals in 2025 Q4 according to their latest regulatory filings, with 165 funds opening new positions, 286 increasing their positions, 289 reducing their positions, and 118 closing their positions.

New
Increased
Maintained
Reduced
Closed

more call options, than puts

Call options by funds: $ | Put options by funds: $

more first-time investments, than exits

New positions opened: | Existing positions closed:

more funds holding

Funds holding:

less ownership

Funds ownership:

1% less repeat investments, than reductions

Existing positions increased: 286 | Existing positions reduced: 289

13% less capital invested

Capital invested by funds: $59.2B → $51.7B (-$7.51B)

69% less funds holding in top 10

Funds holding in top 10: 134 (-9)

Holders
839
Holders Change
Holders Change %
% of All Funds
Holding in Top 10
4
Holding in Top 10 Change
Holding in Top 10 Change %
% of All Funds
New
Increased
Reduced
Closed
Calls
$760M
Puts
$494M
Net Calls
Net Calls Change

Top Buyers

1 +$303M
2 +$220M
3 +$149M
4
D.E. Shaw & Co
D.E. Shaw & Co
New York
+$108M
5
Morgan Stanley
Morgan Stanley
New York
+$108M

Top Sellers

1 -$635M
2 -$383M
3 -$360M
4
Jane Street
Jane Street
New York
-$287M
5
Macquarie Group
Macquarie Group
Australia
-$276M
Name Holding Trade Value Shares
Change
Change in
Stake
VSQM
451
V-Square Quantitative Management
Illinois
$779K
Kovitz Investment Group Partners
452
Kovitz Investment Group Partners
Illinois
$778K
BWMG
453
Bannerman Wealth Management Group
Texas
$774K
A
454
AlphaQuest
New York
$748K
XT
455
XTX Topco
Cayman Islands
$738K
GRP
456
Global Retirement Partners
California
$738K
KAS
457
Kestra Advisory Services
Texas
$736K
MAS
458
Meeder Advisory Services
Ohio
$731K
SFI
459
Siemens Fonds Invest
Germany
$730K
GA
460
GraniteShares Advisors
New York
$710K
O
461
Ossiam
France
$710K
EPW
462
Evolve Private Wealth
California
$709K
WP
463
Woodline Partners
California
$699K
DC
464
Davenport & Co
Virginia
$699K
SBF
465
Sara-Bay Financial
Florida
$695K
NYLIM
466
New York Life Investment Management
New York
$694K
NAM
467
NorthCrest Asset Manangement
Minnesota
$689K
BP
468
Ballentine Partners
Massachusetts
$684K
VIA
469
Virtus Investment Advisers
Connecticut
$683K
HWM
470
HB Wealth Management
Georgia
$677K
FSA
471
Fort Sheridan Advisors
Illinois
$676K
JSAM
472
J. Safra Asset Management
New York
$652K
EA
473
Emerald Advisers
Pennsylvania
$645K
CCM
474
Coldstream Capital Management
Washington
$626K
DT
475
Diversified Trust
Tennessee
$616K