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Alnylam Pharmaceuticals

833 hedge funds and large institutions have $51.6B invested in Alnylam Pharmaceuticals in 2025 Q4 according to their latest regulatory filings, with 160 funds opening new positions, 284 increasing their positions, 290 reducing their positions, and 115 closing their positions.

New
Increased
Maintained
Reduced
Closed

more call options, than puts

Call options by funds: $ | Put options by funds: $

more first-time investments, than exits

New positions opened: | Existing positions closed:

more funds holding

Funds holding:

less ownership

Funds ownership:

2% less repeat investments, than reductions

Existing positions increased: 284 | Existing positions reduced: 290

13% less capital invested

Capital invested by funds: $59.2B → $51.6B (-$7.56B)

69% less funds holding in top 10

Funds holding in top 10: 134 (-9)

Holders
833
Holders Change
Holders Change %
% of All Funds
Holding in Top 10
4
Holding in Top 10 Change
Holding in Top 10 Change %
% of All Funds
New
Increased
Reduced
Closed
Calls
$760M
Puts
$448M
Net Calls
Net Calls Change

Top Buyers

1 +$303M
2 +$220M
3 +$158M
4
UBS Group
UBS Group
Switzerland
+$149M
5
D.E. Shaw & Co
D.E. Shaw & Co
New York
+$108M

Top Sellers

1 -$635M
2 -$383M
3 -$360M
4
Jane Street
Jane Street
New York
-$287M
5
Macquarie Group
Macquarie Group
Australia
-$276M
Name Holding Trade Value Shares
Change
Change in
Stake
Kovitz Investment Group Partners
451
Kovitz Investment Group Partners
Illinois
$778K
BWMG
452
Bannerman Wealth Management Group
Texas
$774K
A
453
AlphaQuest
New York
$748K
XT
454
XTX Topco
Cayman Islands
$738K
GRP
455
Global Retirement Partners
California
$738K
KAS
456
Kestra Advisory Services
Texas
$736K
MAS
457
Meeder Advisory Services
Ohio
$731K
SFI
458
Siemens Fonds Invest
Germany
$730K
GA
459
GraniteShares Advisors
New York
$710K
O
460
Ossiam
France
$710K
EPW
461
Evolve Private Wealth
California
$709K
WP
462
Woodline Partners
California
$699K
DC
463
Davenport & Co
Virginia
$699K
SBF
464
Sara-Bay Financial
Florida
$695K
NYLIM
465
New York Life Investment Management
New York
$694K
NAM
466
NorthCrest Asset Manangement
Minnesota
$689K
BP
467
Ballentine Partners
Massachusetts
$684K
VIA
468
Virtus Investment Advisers
Connecticut
$683K
HWM
469
HB Wealth Management
Georgia
$677K
FSA
470
Fort Sheridan Advisors
Illinois
$676K
JSAM
471
J. Safra Asset Management
New York
$652K
EA
472
Emerald Advisers
Pennsylvania
$645K
CCM
473
Coldstream Capital Management
Washington
$626K
DT
474
Diversified Trust
Tennessee
$616K
FFM
475
Forum Financial Management
Illinois
$615K