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Alnylam Pharmaceuticals

839 hedge funds and large institutions have $51.7B invested in Alnylam Pharmaceuticals in 2025 Q4 according to their latest regulatory filings, with 165 funds opening new positions, 286 increasing their positions, 289 reducing their positions, and 118 closing their positions.

New
Increased
Maintained
Reduced
Closed

more call options, than puts

Call options by funds: $ | Put options by funds: $

more first-time investments, than exits

New positions opened: | Existing positions closed:

more funds holding

Funds holding:

less ownership

Funds ownership:

1% less repeat investments, than reductions

Existing positions increased: 286 | Existing positions reduced: 289

13% less capital invested

Capital invested by funds: $59.2B → $51.7B (-$7.51B)

69% less funds holding in top 10

Funds holding in top 10: 134 (-9)

Holders
839
Holders Change
Holders Change %
% of All Funds
Holding in Top 10
4
Holding in Top 10 Change
Holding in Top 10 Change %
% of All Funds
New
Increased
Reduced
Closed
Calls
$760M
Puts
$494M
Net Calls
Net Calls Change

Top Buyers

1 +$303M
2 +$220M
3 +$149M
4
D.E. Shaw & Co
D.E. Shaw & Co
New York
+$108M
5
Morgan Stanley
Morgan Stanley
New York
+$108M

Top Sellers

1 -$635M
2 -$383M
3 -$360M
4
Jane Street
Jane Street
New York
-$287M
5
Macquarie Group
Macquarie Group
Australia
-$276M
Name Holding Trade Value Shares
Change
Change in
Stake
PSC
426
Portman Square Capital
United Kingdom
$977K
UCFA
427
United Capital Financial Advisors
Texas
$974K
IG
428
ING Group
Netherlands
$972K
DAM
429
Draper Asset Management
New York
$963K
I
430
InceptionR
California
$960K
CPBTD
431
Central Pacific Bank - Trust Division
Hawaii
$960K
PAS
432
Park Avenue Securities
New York
$951K
HKAM
433
Horizon Kinetics Asset Management
New York
$945K
QCM
434
QRG Capital Management
Illinois
$940K
ETC
435
Exchange Traded Concepts
Oklahoma
$939K
NPT
436
Nixon Peabody Trust
Massachusetts
$929K
Vontobel Holding
437
Vontobel Holding
Switzerland
$922K
CCM
438
Capstone Capital Management
$915K
TCM
439
Twin Capital Management
Pennsylvania
$878K
PAG
440
Private Advisory Group
Washington
$857K
IPAM
441
ICICI Prudential Asset Management
India
$843K
AGM
442
Alpine Global Management
New York
$820K
DS
443
DRW Securities
Illinois
$812K
ACS
444
Archford Capital Strategies
Illinois
$805K
EPM
445
Elm Partners Management
Pennsylvania
$798K
SNBOSD
446
Security National Bank of So Dak
Iowa
$795K
TG
447
TCW Group
California
$795K
SCP
448
Sivia Capital Partners
California
$794K
TE
449
Tema ETFs
New York
$794K
S
450
SignatureFD
Georgia
$788K