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Alnylam Pharmaceuticals

846 hedge funds and large institutions have $51.7B invested in Alnylam Pharmaceuticals in 2025 Q4 according to their latest regulatory filings, with 169 funds opening new positions, 288 increasing their positions, 290 reducing their positions, and 118 closing their positions.

New
Increased
Maintained
Reduced
Closed

more call options, than puts

Call options by funds: $ | Put options by funds: $

more first-time investments, than exits

New positions opened: | Existing positions closed:

more funds holding

Funds holding:

less repeat investments, than reductions

Existing positions increased: | Existing positions reduced:

0.83% less ownership

Funds ownership: 99.03%98.2% (-0.83%)

13% less capital invested

Capital invested by funds: $59.2B → $51.7B (-$7.48B)

69% less funds holding in top 10

Funds holding in top 10: 134 (-9)

Holders
846
Holders Change
Holders Change %
% of All Funds
Holding in Top 10
4
Holding in Top 10 Change
Holding in Top 10 Change %
% of All Funds
New
Increased
Reduced
Closed
Calls
$760M
Puts
$494M
Net Calls
Net Calls Change

Top Buyers

1 +$303M
2 +$220M
3 +$149M
4
D.E. Shaw & Co
D.E. Shaw & Co
New York
+$108M
5
Morgan Stanley
Morgan Stanley
New York
+$108M

Top Sellers

1 -$635M
2 -$383M
3 -$360M
4
Jane Street
Jane Street
New York
-$287M
5
Macquarie Group
Macquarie Group
Australia
-$276M
Name Holding Trade Value Shares
Change
Change in
Stake
UM
426
UniSuper Management
Australia
$994K
TF
427
Theory Financial
Colorado
$992K
PSC
428
Portman Square Capital
United Kingdom
$977K
UCFA
429
United Capital Financial Advisors
Texas
$974K
IG
430
ING Group
Netherlands
$972K
DAM
431
Draper Asset Management
New York
$963K
I
432
InceptionR
California
$960K
CPBTD
433
Central Pacific Bank - Trust Division
Hawaii
$960K
PAS
434
Park Avenue Securities
New York
$951K
HKAM
435
Horizon Kinetics Asset Management
New York
$945K
QCM
436
QRG Capital Management
Illinois
$940K
ETC
437
Exchange Traded Concepts
Oklahoma
$939K
NPT
438
Nixon Peabody Trust
Massachusetts
$929K
Vontobel Holding
439
Vontobel Holding
Switzerland
$922K
CCM
440
Capstone Capital Management
$915K
TCM
441
Twin Capital Management
Pennsylvania
$878K
PAG
442
Private Advisory Group
Washington
$857K
IPAM
443
ICICI Prudential Asset Management
India
$843K
AGM
444
Alpine Global Management
New York
$820K
DS
445
DRW Securities
Illinois
$812K
ACS
446
Archford Capital Strategies
Illinois
$805K
EPM
447
Elm Partners Management
Pennsylvania
$798K
SNBOSD
448
Security National Bank of So Dak
Iowa
$795K
TG
449
TCW Group
California
$795K
SCP
450
Sivia Capital Partners
California
$794K