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Alnylam Pharmaceuticals

833 hedge funds and large institutions have $51.6B invested in Alnylam Pharmaceuticals in 2025 Q4 according to their latest regulatory filings, with 160 funds opening new positions, 284 increasing their positions, 290 reducing their positions, and 115 closing their positions.

New
Increased
Maintained
Reduced
Closed

more call options, than puts

Call options by funds: $ | Put options by funds: $

more first-time investments, than exits

New positions opened: | Existing positions closed:

more funds holding

Funds holding:

less ownership

Funds ownership:

2% less repeat investments, than reductions

Existing positions increased: 284 | Existing positions reduced: 290

13% less capital invested

Capital invested by funds: $59.2B → $51.6B (-$7.56B)

69% less funds holding in top 10

Funds holding in top 10: 134 (-9)

Holders
833
Holders Change
Holders Change %
% of All Funds
Holding in Top 10
4
Holding in Top 10 Change
Holding in Top 10 Change %
% of All Funds
New
Increased
Reduced
Closed
Calls
$760M
Puts
$448M
Net Calls
Net Calls Change

Top Buyers

1 +$303M
2 +$220M
3 +$158M
4
UBS Group
UBS Group
Switzerland
+$149M
5
D.E. Shaw & Co
D.E. Shaw & Co
New York
+$108M

Top Sellers

1 -$635M
2 -$383M
3 -$360M
4
Jane Street
Jane Street
New York
-$287M
5
Macquarie Group
Macquarie Group
Australia
-$276M
Name Holding Trade Value Shares
Change
Change in
Stake
UCFA
426
United Capital Financial Advisors
Texas
$974K
IG
427
ING Group
Netherlands
$972K
DAM
428
Draper Asset Management
New York
$963K
I
429
InceptionR
California
$960K
CPBTD
430
Central Pacific Bank - Trust Division
Hawaii
$960K
PAS
431
Park Avenue Securities
New York
$951K
HKAM
432
Horizon Kinetics Asset Management
New York
$945K
QCM
433
QRG Capital Management
Illinois
$940K
ETC
434
Exchange Traded Concepts
Oklahoma
$939K
NPT
435
Nixon Peabody Trust
Massachusetts
$929K
Vontobel Holding
436
Vontobel Holding
Switzerland
$922K
CCM
437
Capstone Capital Management
$915K
TCM
438
Twin Capital Management
Pennsylvania
$878K
PAG
439
Private Advisory Group
Washington
$857K
IPAM
440
ICICI Prudential Asset Management
India
$843K
AGM
441
Alpine Global Management
New York
$820K
DS
442
DRW Securities
Illinois
$812K
ACS
443
Archford Capital Strategies
Illinois
$805K
EPM
444
Elm Partners Management
Pennsylvania
$798K
SNBOSD
445
Security National Bank of So Dak
Iowa
$795K
TG
446
TCW Group
California
$795K
SCP
447
Sivia Capital Partners
California
$794K
TE
448
Tema ETFs
New York
$794K
S
449
SignatureFD
Georgia
$788K
VSQM
450
V-Square Quantitative Management
Illinois
$779K