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Alnylam Pharmaceuticals

846 hedge funds and large institutions have $51.7B invested in Alnylam Pharmaceuticals in 2025 Q4 according to their latest regulatory filings, with 169 funds opening new positions, 288 increasing their positions, 290 reducing their positions, and 118 closing their positions.

New
Increased
Maintained
Reduced
Closed

more call options, than puts

Call options by funds: $ | Put options by funds: $

more first-time investments, than exits

New positions opened: | Existing positions closed:

more funds holding

Funds holding:

less repeat investments, than reductions

Existing positions increased: | Existing positions reduced:

0.83% less ownership

Funds ownership: 99.03%98.2% (-0.83%)

13% less capital invested

Capital invested by funds: $59.2B → $51.7B (-$7.48B)

69% less funds holding in top 10

Funds holding in top 10: 134 (-9)

Holders
846
Holders Change
Holders Change %
% of All Funds
Holding in Top 10
4
Holding in Top 10 Change
Holding in Top 10 Change %
% of All Funds
New
Increased
Reduced
Closed
Calls
$760M
Puts
$494M
Net Calls
Net Calls Change

Top Buyers

1 +$303M
2 +$220M
3 +$149M
4
D.E. Shaw & Co
D.E. Shaw & Co
New York
+$108M
5
Morgan Stanley
Morgan Stanley
New York
+$108M

Top Sellers

1 -$635M
2 -$383M
3 -$360M
4
Jane Street
Jane Street
New York
-$287M
5
Macquarie Group
Macquarie Group
Australia
-$276M
Name Holding Trade Value Shares
Change
Change in
Stake
PCM
401
Polymer Capital Management
New York
$1.22M
Cambridge Investment Research Advisors
402
Cambridge Investment Research Advisors
Iowa
$1.21M
Balyasny Asset Management
403
Balyasny Asset Management
Illinois
$1.2M
NA
404
NewEdge Advisors
Louisiana
$1.2M
SGH
405
Sivik Global Healthcare
Connecticut
$1.19M
SAM
406
Sectoral Asset Management
Quebec, Canada
$1.19M
ECM
407
Everence Capital Management
Indiana
$1.18M
OCM
408
Orion Capital Management
California
$1.18M
VF
409
Virtu Financial
New York
$1.17M
GIC
410
Generali Investments CEE
Czech Republic
$1.15M
LJHT
411
Laurie J. Hall Trustee
$1.12M
RSWM
412
Robertson Stephens Wealth Management
California
$1.11M
SFP
413
Shepherd Financial Partners
Massachusetts
$1.09M
GT
414
Greenleaf Trust
Michigan
$1.09M
WFC
415
Western Financial Corp
California
$1.09M
RIA
416
Regal Investment Advisors
Michigan
$1.08M
P
417
&Partners
Tennessee
$1.07M
AIM
418
Anchor Investment Management
South Carolina
$1.07M
FDP
419
Financiere des Professionnels
Quebec, Canada
$1.07M
MUMSS
420
Mitsubishi UFJ Morgan Stanley Securities
Japan
$1.07M
CRC
421
Curi RMB Capital
Illinois
$1.06M
PS
422
Principal Securities
Iowa
$1.04M
CL
423
Choreo LLC
Illinois
$1.02M
EFG
424
Everhart Financial Group
Ohio
$1.01M
OAM
425
Oxford Asset Management
United Kingdom
$1.01M