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Alnylam Pharmaceuticals

833 hedge funds and large institutions have $51.6B invested in Alnylam Pharmaceuticals in 2025 Q4 according to their latest regulatory filings, with 160 funds opening new positions, 284 increasing their positions, 290 reducing their positions, and 115 closing their positions.

New
Increased
Maintained
Reduced
Closed

more call options, than puts

Call options by funds: $ | Put options by funds: $

more first-time investments, than exits

New positions opened: | Existing positions closed:

more funds holding

Funds holding:

less ownership

Funds ownership:

2% less repeat investments, than reductions

Existing positions increased: 284 | Existing positions reduced: 290

13% less capital invested

Capital invested by funds: $59.2B → $51.6B (-$7.56B)

69% less funds holding in top 10

Funds holding in top 10: 134 (-9)

Holders
833
Holders Change
Holders Change %
% of All Funds
Holding in Top 10
4
Holding in Top 10 Change
Holding in Top 10 Change %
% of All Funds
New
Increased
Reduced
Closed
Calls
$760M
Puts
$448M
Net Calls
Net Calls Change

Top Buyers

1 +$303M
2 +$220M
3 +$158M
4
UBS Group
UBS Group
Switzerland
+$149M
5
D.E. Shaw & Co
D.E. Shaw & Co
New York
+$108M

Top Sellers

1 -$635M
2 -$383M
3 -$360M
4
Jane Street
Jane Street
New York
-$287M
5
Macquarie Group
Macquarie Group
Australia
-$276M
Name Holding Trade Value Shares
Change
Change in
Stake
NA
401
NewEdge Advisors
Louisiana
$1.2M
SGH
402
Sivik Global Healthcare
Connecticut
$1.19M
SAM
403
Sectoral Asset Management
Quebec, Canada
$1.19M
ECM
404
Everence Capital Management
Indiana
$1.18M
OCM
405
Orion Capital Management
California
$1.18M
VF
406
Virtu Financial
New York
$1.17M
GIC
407
Generali Investments CEE
Czech Republic
$1.15M
LJHT
408
Laurie J. Hall Trustee
$1.12M
RSWM
409
Robertson Stephens Wealth Management
California
$1.11M
SFP
410
Shepherd Financial Partners
Massachusetts
$1.09M
GT
411
Greenleaf Trust
Michigan
$1.09M
WFC
412
Western Financial Corp
California
$1.09M
RIA
413
Regal Investment Advisors
Michigan
$1.08M
P
414
&Partners
Tennessee
$1.07M
AIM
415
Anchor Investment Management
South Carolina
$1.07M
FDP
416
Financiere des Professionnels
Quebec, Canada
$1.07M
MUMSS
417
Mitsubishi UFJ Morgan Stanley Securities
Japan
$1.07M
CRC
418
Curi RMB Capital
Illinois
$1.06M
PS
419
Principal Securities
Iowa
$1.04M
CL
420
Choreo LLC
Illinois
$1.02M
EFG
421
Everhart Financial Group
Ohio
$1.01M
OAM
422
Oxford Asset Management
United Kingdom
$1.01M
UM
423
UniSuper Management
Australia
$994K
TF
424
Theory Financial
Colorado
$992K
PSC
425
Portman Square Capital
United Kingdom
$977K