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Alnylam Pharmaceuticals

839 hedge funds and large institutions have $51.7B invested in Alnylam Pharmaceuticals in 2025 Q4 according to their latest regulatory filings, with 165 funds opening new positions, 286 increasing their positions, 289 reducing their positions, and 118 closing their positions.

New
Increased
Maintained
Reduced
Closed

more call options, than puts

Call options by funds: $ | Put options by funds: $

more first-time investments, than exits

New positions opened: | Existing positions closed:

more funds holding

Funds holding:

less ownership

Funds ownership:

1% less repeat investments, than reductions

Existing positions increased: 286 | Existing positions reduced: 289

13% less capital invested

Capital invested by funds: $59.2B → $51.7B (-$7.51B)

69% less funds holding in top 10

Funds holding in top 10: 134 (-9)

Holders
839
Holders Change
Holders Change %
% of All Funds
Holding in Top 10
4
Holding in Top 10 Change
Holding in Top 10 Change %
% of All Funds
New
Increased
Reduced
Closed
Calls
$760M
Puts
$494M
Net Calls
Net Calls Change

Top Buyers

1 +$303M
2 +$220M
3 +$149M
4
D.E. Shaw & Co
D.E. Shaw & Co
New York
+$108M
5
Morgan Stanley
Morgan Stanley
New York
+$108M

Top Sellers

1 -$635M
2 -$383M
3 -$360M
4
Jane Street
Jane Street
New York
-$287M
5
Macquarie Group
Macquarie Group
Australia
-$276M
Name Holding Trade Value Shares
Change
Change in
Stake
HCM
376
Howard Capital Management
Georgia
$1.46M
Twin Tree Management
377
Twin Tree Management
Texas
$1.45M
BM
378
Brandywine Managers
Delaware
$1.44M
CFO
379
Callan Family Office
Pennsylvania
$1.44M
SCM
380
Sterling Capital Management
North Carolina
$1.41M
VI
381
Vestcor Inc
New Brunswick, Canada
$1.41M
STA
382
Summit Trail Advisors
New York
$1.4M
LNWTC
383
Laird Norton Wetherby Trust Company
Washington
$1.39M
BAMCO Inc
384
BAMCO Inc
New York
$1.39M
DZ Bank
385
DZ Bank
Germany
$1.39M
Principal Financial Group
386
Principal Financial Group
Iowa
$1.39M
FC
387
FORA Capital
Florida
$1.38M
SC
388
SummitTX Capital
Texas
$1.38M
JGC
389
J. Goldman & Co
New York
$1.34M
SPAS
390
Spectrum Planning & Advisory Services
California
$1.33M
KeyBank National Association
391
KeyBank National Association
Ohio
$1.33M
SOAM
392
SBI Okasan Asset Management
Japan
$1.31M
KRSITF
393
Kentucky Retirement Systems Insurance Trust Fund
Kentucky
$1.31M
VFA
394
Values First Advisors
Tennessee
$1.28M
EI
395
Ethic Inc
New York
$1.28M
KCM
396
Kennedy Capital Management
Missouri
$1.28M
SLI
397
Sumitomo Life Insurance
Japan
$1.27M
GD
398
Grandfield & Dodd
New York
$1.24M
PCM
399
Polymer Capital Management
New York
$1.22M
Cambridge Investment Research Advisors
400
Cambridge Investment Research Advisors
Iowa
$1.21M