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Alnylam Pharmaceuticals

833 hedge funds and large institutions have $51.6B invested in Alnylam Pharmaceuticals in 2025 Q4 according to their latest regulatory filings, with 160 funds opening new positions, 284 increasing their positions, 290 reducing their positions, and 115 closing their positions.

New
Increased
Maintained
Reduced
Closed

more call options, than puts

Call options by funds: $ | Put options by funds: $

more first-time investments, than exits

New positions opened: | Existing positions closed:

more funds holding

Funds holding:

less ownership

Funds ownership:

2% less repeat investments, than reductions

Existing positions increased: 284 | Existing positions reduced: 290

13% less capital invested

Capital invested by funds: $59.2B → $51.6B (-$7.56B)

69% less funds holding in top 10

Funds holding in top 10: 134 (-9)

Holders
833
Holders Change
Holders Change %
% of All Funds
Holding in Top 10
4
Holding in Top 10 Change
Holding in Top 10 Change %
% of All Funds
New
Increased
Reduced
Closed
Calls
$760M
Puts
$448M
Net Calls
Net Calls Change

Top Buyers

1 +$303M
2 +$220M
3 +$158M
4
UBS Group
UBS Group
Switzerland
+$149M
5
D.E. Shaw & Co
D.E. Shaw & Co
New York
+$108M

Top Sellers

1 -$635M
2 -$383M
3 -$360M
4
Jane Street
Jane Street
New York
-$287M
5
Macquarie Group
Macquarie Group
Australia
-$276M
Name Holding Trade Value Shares
Change
Change in
Stake
Twin Tree Management
376
Twin Tree Management
Texas
$1.45M
BM
377
Brandywine Managers
Delaware
$1.44M
CFO
378
Callan Family Office
Pennsylvania
$1.44M
SCM
379
Sterling Capital Management
North Carolina
$1.41M
VI
380
Vestcor Inc
New Brunswick, Canada
$1.41M
STA
381
Summit Trail Advisors
New York
$1.4M
LNWTC
382
Laird Norton Wetherby Trust Company
Washington
$1.39M
BAMCO Inc
383
BAMCO Inc
New York
$1.39M
DZ Bank
384
DZ Bank
Germany
$1.39M
Principal Financial Group
385
Principal Financial Group
Iowa
$1.39M
FC
386
FORA Capital
Florida
$1.38M
SC
387
SummitTX Capital
Texas
$1.38M
JGC
388
J. Goldman & Co
New York
$1.34M
SPAS
389
Spectrum Planning & Advisory Services
California
$1.33M
KeyBank National Association
390
KeyBank National Association
Ohio
$1.33M
SOAM
391
SBI Okasan Asset Management
Japan
$1.31M
KRSITF
392
Kentucky Retirement Systems Insurance Trust Fund
Kentucky
$1.31M
VFA
393
Values First Advisors
Tennessee
$1.28M
EI
394
Ethic Inc
New York
$1.28M
KCM
395
Kennedy Capital Management
Missouri
$1.28M
SLI
396
Sumitomo Life Insurance
Japan
$1.27M
GD
397
Grandfield & Dodd
New York
$1.24M
PCM
398
Polymer Capital Management
New York
$1.22M
Cambridge Investment Research Advisors
399
Cambridge Investment Research Advisors
Iowa
$1.21M
Balyasny Asset Management
400
Balyasny Asset Management
Illinois
$1.2M