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Alnylam Pharmaceuticals

833 hedge funds and large institutions have $51.6B invested in Alnylam Pharmaceuticals in 2025 Q4 according to their latest regulatory filings, with 160 funds opening new positions, 284 increasing their positions, 290 reducing their positions, and 115 closing their positions.

New
Increased
Maintained
Reduced
Closed

more call options, than puts

Call options by funds: $ | Put options by funds: $

more first-time investments, than exits

New positions opened: | Existing positions closed:

more funds holding

Funds holding:

less ownership

Funds ownership:

2% less repeat investments, than reductions

Existing positions increased: 284 | Existing positions reduced: 290

13% less capital invested

Capital invested by funds: $59.2B → $51.6B (-$7.56B)

69% less funds holding in top 10

Funds holding in top 10: 134 (-9)

Holders
833
Holders Change
Holders Change %
% of All Funds
Holding in Top 10
4
Holding in Top 10 Change
Holding in Top 10 Change %
% of All Funds
New
Increased
Reduced
Closed
Calls
$760M
Puts
$448M
Net Calls
Net Calls Change

Top Buyers

1 +$303M
2 +$220M
3 +$158M
4
UBS Group
UBS Group
Switzerland
+$149M
5
D.E. Shaw & Co
D.E. Shaw & Co
New York
+$108M

Top Sellers

1 -$635M
2 -$383M
3 -$360M
4
Jane Street
Jane Street
New York
-$287M
5
Macquarie Group
Macquarie Group
Australia
-$276M
Name Holding Trade Value Shares
Change
Change in
Stake
EOJOAM
351
E. Ohman J:or Asset Management
Sweden
$1.82M
BC
352
Burney Company
Virginia
$1.82M
OAC
353
OMERS Administration Corp
Ontario, Canada
$1.8M
MFG
354
Merit Financial Group
Georgia
$1.79M
NB
355
Norinchukin Bank
Japan
$1.78M
BHCM
356
Brevan Howard Capital Management
Jersey
$1.76M
BCI
357
Brinker Capital Investments
Pennsylvania
$1.75M
Envestnet Portfolio Solutions
358
Envestnet Portfolio Solutions
Illinois
$1.73M
QIM
359
Quantitative Investment Management
Virginia
$1.72M
AAM
360
Advisors Asset Management
Colorado
$1.71M
NSUP
361
NLB Skladi upravljanje premozenja
$1.71M
HHGC
362
Hunting Hill Global Capital
New York
$1.69M
HCM
363
Howland Capital Management
Massachusetts
$1.69M
IWC
364
Integrated Wealth Concepts
Massachusetts
$1.69M
SFA
365
Sequoia Financial Advisors
Ohio
$1.67M
MGP
366
Metis Global Partners
California
$1.66M
PCA
367
Pallas Capital Advisors
Massachusetts
$1.63M
FPAS
368
Focus Partners Advisor Solutions
Missouri
$1.63M
Comerica Bank
369
Comerica Bank
Texas
$1.61M
GC
370
Gilbert & Cook
Iowa
$1.6M
Verition Fund Management
371
Verition Fund Management
Connecticut
$1.59M
CT
372
Clearstead Trust
Maine
$1.58M
6CM
373
683 Capital Management
New York
$1.5M
FA
374
Faithward Advisors
Pennsylvania
$1.5M
HCM
375
Howard Capital Management
Georgia
$1.46M