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Alnylam Pharmaceuticals

839 hedge funds and large institutions have $51.7B invested in Alnylam Pharmaceuticals in 2025 Q4 according to their latest regulatory filings, with 165 funds opening new positions, 286 increasing their positions, 289 reducing their positions, and 118 closing their positions.

New
Increased
Maintained
Reduced
Closed

more call options, than puts

Call options by funds: $ | Put options by funds: $

more first-time investments, than exits

New positions opened: | Existing positions closed:

more funds holding

Funds holding:

less ownership

Funds ownership:

1% less repeat investments, than reductions

Existing positions increased: 286 | Existing positions reduced: 289

13% less capital invested

Capital invested by funds: $59.2B → $51.7B (-$7.51B)

69% less funds holding in top 10

Funds holding in top 10: 134 (-9)

Holders
839
Holders Change
Holders Change %
% of All Funds
Holding in Top 10
4
Holding in Top 10 Change
Holding in Top 10 Change %
% of All Funds
New
Increased
Reduced
Closed
Calls
$760M
Puts
$494M
Net Calls
Net Calls Change

Top Buyers

1 +$303M
2 +$220M
3 +$149M
4
D.E. Shaw & Co
D.E. Shaw & Co
New York
+$108M
5
Morgan Stanley
Morgan Stanley
New York
+$108M

Top Sellers

1 -$635M
2 -$383M
3 -$360M
4
Jane Street
Jane Street
New York
-$287M
5
Macquarie Group
Macquarie Group
Australia
-$276M
Name Holding Trade Value Shares
Change
Change in
Stake
AI
326
Atria Investments
North Carolina
$2.45M
Pathstone Holdings
327
Pathstone Holdings
New Jersey
$2.44M
Truist Financial
328
Truist Financial
North Carolina
$2.43M
CI Investments Inc
329
CI Investments Inc
Ontario, Canada
$2.41M
KIM
330
Kestra Investment Management
Texas
$2.39M
BCM
331
Bridgeway Capital Management
Texas
$2.38M
Walleye Capital
332
Walleye Capital
New York
$2.37M
TRCT
333
Tower Research Capital (TRC)
New York
$2.32M
AAIS
334
ABN AMRO Investment Solutions
$2.29M
ALMGDA
335
AG2R La Mondiale Gestion d'Actifs
France
$2.22M
DP
336
Diadema Partners
New Jersey
$2.12M
WBC
337
Westpac Banking Corp
Australia
$2.11M
GCM
338
Genus Capital Management
British Columbia, Canada
$2.09M
BMSSC
339
B. Metzler seel. Sohn & Co
Germany
$2.09M
US Bancorp
340
US Bancorp
Minnesota
$2.08M
VA
341
Vident Advisory
Georgia
$2.05M
GIA
342
Gateway Investment Advisers
Ohio
$2.04M
PL
343
Perpetual Ltd
Australia
$2M
TMAM
344
Tokio Marine Asset Management
Japan
$1.99M
SPS
345
Susquehanna Portfolio Strategies
Pennsylvania
$1.99M
WMA
346
West Michigan Advisors
Michigan
$1.99M
TI
347
Tidal Investments
Wisconsin
$1.92M
A
348
AustralianSuper
Australia
$1.91M
NDSIB
349
North Dakota State Investment Board
North Dakota
$1.9M
AIP
350
Ameritas Investment Partners
Nebraska
$1.9M