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Alnylam Pharmaceuticals

833 hedge funds and large institutions have $51.6B invested in Alnylam Pharmaceuticals in 2025 Q4 according to their latest regulatory filings, with 160 funds opening new positions, 284 increasing their positions, 290 reducing their positions, and 115 closing their positions.

New
Increased
Maintained
Reduced
Closed

more call options, than puts

Call options by funds: $ | Put options by funds: $

more first-time investments, than exits

New positions opened: | Existing positions closed:

more funds holding

Funds holding:

less ownership

Funds ownership:

2% less repeat investments, than reductions

Existing positions increased: 284 | Existing positions reduced: 290

13% less capital invested

Capital invested by funds: $59.2B → $51.6B (-$7.56B)

69% less funds holding in top 10

Funds holding in top 10: 134 (-9)

Holders
833
Holders Change
Holders Change %
% of All Funds
Holding in Top 10
4
Holding in Top 10 Change
Holding in Top 10 Change %
% of All Funds
New
Increased
Reduced
Closed
Calls
$760M
Puts
$448M
Net Calls
Net Calls Change

Top Buyers

1 +$303M
2 +$220M
3 +$158M
4
UBS Group
UBS Group
Switzerland
+$149M
5
D.E. Shaw & Co
D.E. Shaw & Co
New York
+$108M

Top Sellers

1 -$635M
2 -$383M
3 -$360M
4
Jane Street
Jane Street
New York
-$287M
5
Macquarie Group
Macquarie Group
Australia
-$276M
Name Holding Trade Value Shares
Change
Change in
Stake
Pathstone Holdings
326
Pathstone Holdings
New Jersey
$2.44M
Truist Financial
327
Truist Financial
North Carolina
$2.43M
CI Investments Inc
328
CI Investments Inc
Ontario, Canada
$2.41M
KIM
329
Kestra Investment Management
Texas
$2.39M
BCM
330
Bridgeway Capital Management
Texas
$2.38M
Walleye Capital
331
Walleye Capital
New York
$2.37M
TRCT
332
Tower Research Capital (TRC)
New York
$2.32M
AAIS
333
ABN AMRO Investment Solutions
$2.29M
ALMGDA
334
AG2R La Mondiale Gestion d'Actifs
France
$2.22M
DP
335
Diadema Partners
New Jersey
$2.12M
WBC
336
Westpac Banking Corp
Australia
$2.11M
GCM
337
Genus Capital Management
British Columbia, Canada
$2.09M
BMSSC
338
B. Metzler seel. Sohn & Co
Germany
$2.09M
US Bancorp
339
US Bancorp
Minnesota
$2.08M
VA
340
Vident Advisory
Georgia
$2.05M
GIA
341
Gateway Investment Advisers
Ohio
$2.04M
PL
342
Perpetual Ltd
Australia
$2M
TMAM
343
Tokio Marine Asset Management
Japan
$1.99M
SPS
344
Susquehanna Portfolio Strategies
Pennsylvania
$1.99M
WMA
345
West Michigan Advisors
Michigan
$1.99M
TI
346
Tidal Investments
Wisconsin
$1.92M
A
347
AustralianSuper
Australia
$1.91M
NDSIB
348
North Dakota State Investment Board
North Dakota
$1.9M
AIP
349
Ameritas Investment Partners
Nebraska
$1.9M
AAM
350
Azzad Asset Management
Virginia
$1.83M