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Alnylam Pharmaceuticals

839 hedge funds and large institutions have $51.7B invested in Alnylam Pharmaceuticals in 2025 Q4 according to their latest regulatory filings, with 165 funds opening new positions, 286 increasing their positions, 289 reducing their positions, and 118 closing their positions.

New
Increased
Maintained
Reduced
Closed

more call options, than puts

Call options by funds: $ | Put options by funds: $

more first-time investments, than exits

New positions opened: | Existing positions closed:

more funds holding

Funds holding:

less ownership

Funds ownership:

1% less repeat investments, than reductions

Existing positions increased: 286 | Existing positions reduced: 289

13% less capital invested

Capital invested by funds: $59.2B → $51.7B (-$7.51B)

69% less funds holding in top 10

Funds holding in top 10: 134 (-9)

Holders
839
Holders Change
Holders Change %
% of All Funds
Holding in Top 10
4
Holding in Top 10 Change
Holding in Top 10 Change %
% of All Funds
New
Increased
Reduced
Closed
Calls
$760M
Puts
$494M
Net Calls
Net Calls Change

Top Buyers

1 +$303M
2 +$220M
3 +$149M
4
D.E. Shaw & Co
D.E. Shaw & Co
New York
+$108M
5
Morgan Stanley
Morgan Stanley
New York
+$108M

Top Sellers

1 -$635M
2 -$383M
3 -$360M
4
Jane Street
Jane Street
New York
-$287M
5
Macquarie Group
Macquarie Group
Australia
-$276M
Name Holding Trade Value Shares
Change
Change in
Stake
TFA
301
Transamerica Financial Advisors
Florida
$3.42M
SCI
302
S&CO Inc
Massachusetts
$3.26M
MIM
303
MetLife Investment Management
New Jersey
$3.26M
Rockefeller Capital Management
304
Rockefeller Capital Management
New York
$3.23M
ASN
305
Advisory Services Network
Georgia
$3.22M
M&T Bank
306
M&T Bank
New York
$3.17M
DJSG
307
D.J. St. Germain
Massachusetts
$3.12M
KRS
308
Kentucky Retirement Systems
Kentucky
$3.12M
PP
309
Prudential plc
United Kingdom
$3.11M
LA
310
LBP AM
France
$3.1M
Bank of Nova Scotia
311
Bank of Nova Scotia
Ontario, Canada
$3.08M
OIMU
312
Osmosis Investment Management UK
United Kingdom
$3.06M
NW
313
NewEdge Wealth
Pennsylvania
$2.99M
EP
314
Edgestream Partners
New Jersey
$2.88M
JPMIA
315
J.P. Marvel Investment Advisors
Massachusetts
$2.83M
Focus Partners Wealth
316
Focus Partners Wealth
Massachusetts
$2.82M
PIMJS
317
PKO Investment Management Joint-Stock
Poland
$2.7M
DFCM
318
Dark Forest Capital Management
Puerto Rico
$2.67M
GIBU
319
Gulf International Bank (UK)
United Kingdom
$2.63M
SA
320
Sanctuary Advisors
Indiana
$2.59M
Janney Montgomery Scott
321
Janney Montgomery Scott
Pennsylvania
$2.59M
MSRPS
322
Maryland State Retirement & Pension System
Maryland
$2.52M
HSA
323
Hussman Strategic Advisors
Maryland
$2.51M
PIM
324
Plato Investment Management
Australia
$2.5M
DILIC
325
Dai-ichi Life Insurance Company
Japan
$2.49M