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Alnylam Pharmaceuticals

833 hedge funds and large institutions have $51.6B invested in Alnylam Pharmaceuticals in 2025 Q4 according to their latest regulatory filings, with 160 funds opening new positions, 284 increasing their positions, 290 reducing their positions, and 115 closing their positions.

New
Increased
Maintained
Reduced
Closed

more call options, than puts

Call options by funds: $ | Put options by funds: $

more first-time investments, than exits

New positions opened: | Existing positions closed:

more funds holding

Funds holding:

less ownership

Funds ownership:

2% less repeat investments, than reductions

Existing positions increased: 284 | Existing positions reduced: 290

13% less capital invested

Capital invested by funds: $59.2B → $51.6B (-$7.56B)

69% less funds holding in top 10

Funds holding in top 10: 134 (-9)

Holders
833
Holders Change
Holders Change %
% of All Funds
Holding in Top 10
4
Holding in Top 10 Change
Holding in Top 10 Change %
% of All Funds
New
Increased
Reduced
Closed
Calls
$760M
Puts
$448M
Net Calls
Net Calls Change

Top Buyers

1 +$303M
2 +$220M
3 +$158M
4
UBS Group
UBS Group
Switzerland
+$149M
5
D.E. Shaw & Co
D.E. Shaw & Co
New York
+$108M

Top Sellers

1 -$635M
2 -$383M
3 -$360M
4
Jane Street
Jane Street
New York
-$287M
5
Macquarie Group
Macquarie Group
Australia
-$276M
Name Holding Trade Value Shares
Change
Change in
Stake
SCI
301
S&CO Inc
Massachusetts
$3.26M
MIM
302
MetLife Investment Management
New Jersey
$3.26M
Rockefeller Capital Management
303
Rockefeller Capital Management
New York
$3.23M
ASN
304
Advisory Services Network
Georgia
$3.22M
M&T Bank
305
M&T Bank
New York
$3.17M
DJSG
306
D.J. St. Germain
Massachusetts
$3.12M
KRS
307
Kentucky Retirement Systems
Kentucky
$3.12M
PP
308
Prudential plc
United Kingdom
$3.11M
LA
309
LBP AM
France
$3.1M
Bank of Nova Scotia
310
Bank of Nova Scotia
Ontario, Canada
$3.08M
OIMU
311
Osmosis Investment Management UK
United Kingdom
$3.06M
NW
312
NewEdge Wealth
Pennsylvania
$2.99M
EP
313
Edgestream Partners
New Jersey
$2.88M
JPMIA
314
J.P. Marvel Investment Advisors
Massachusetts
$2.83M
Focus Partners Wealth
315
Focus Partners Wealth
Massachusetts
$2.82M
PIMJS
316
PKO Investment Management Joint-Stock
Poland
$2.7M
DFCM
317
Dark Forest Capital Management
Puerto Rico
$2.67M
GIBU
318
Gulf International Bank (UK)
United Kingdom
$2.63M
SA
319
Sanctuary Advisors
Indiana
$2.59M
Janney Montgomery Scott
320
Janney Montgomery Scott
Pennsylvania
$2.59M
MSRPS
321
Maryland State Retirement & Pension System
Maryland
$2.52M
HSA
322
Hussman Strategic Advisors
Maryland
$2.51M
PIM
323
Plato Investment Management
Australia
$2.5M
DILIC
324
Dai-ichi Life Insurance Company
Japan
$2.49M
AI
325
Atria Investments
North Carolina
$2.45M