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Alnylam Pharmaceuticals

839 hedge funds and large institutions have $51.7B invested in Alnylam Pharmaceuticals in 2025 Q4 according to their latest regulatory filings, with 165 funds opening new positions, 286 increasing their positions, 289 reducing their positions, and 118 closing their positions.

New
Increased
Maintained
Reduced
Closed

more call options, than puts

Call options by funds: $ | Put options by funds: $

more first-time investments, than exits

New positions opened: | Existing positions closed:

more funds holding

Funds holding:

less ownership

Funds ownership:

1% less repeat investments, than reductions

Existing positions increased: 286 | Existing positions reduced: 289

13% less capital invested

Capital invested by funds: $59.2B → $51.7B (-$7.51B)

69% less funds holding in top 10

Funds holding in top 10: 134 (-9)

Holders
839
Holders Change
Holders Change %
% of All Funds
Holding in Top 10
4
Holding in Top 10 Change
Holding in Top 10 Change %
% of All Funds
New
Increased
Reduced
Closed
Calls
$760M
Puts
$494M
Net Calls
Net Calls Change

Top Buyers

1 +$303M
2 +$220M
3 +$149M
4
D.E. Shaw & Co
D.E. Shaw & Co
New York
+$108M
5
Morgan Stanley
Morgan Stanley
New York
+$108M

Top Sellers

1 -$635M
2 -$383M
3 -$360M
4
Jane Street
Jane Street
New York
-$287M
5
Macquarie Group
Macquarie Group
Australia
-$276M
Name Holding Trade Value Shares
Change
Change in
Stake
CFB
276
Cullen/Frost Bankers
Texas
$4.39M
AV
277
ASR Vermogensbeheer
Netherlands
$4.38M
CWM
278
CIBC World Markets
New York
$4.36M
AB
279
Amalgamated Bank
New York
$4.25M
CB
280
Commerce Bank
Missouri
$4.19M
SAM
281
Silvercrest Asset Management
New York
$4.14M
ACM
282
Atika Capital Management
New York
$4.11M
HFM
283
Harvest Fund Management
China
$4.1M
HCS
284
Himension Capital (Singapore)
Singapore
$4.05M
Lazard Asset Management
285
Lazard Asset Management
New York
$4.04M
OSAM
286
O'Shaughnessy Asset Management
Connecticut
$3.95M
AC
287
Allstate Corporation
Illinois
$3.91M
ERSOT
288
Employees Retirement System of Texas
Texas
$3.89M
William Blair & Company
289
William Blair & Company
Illinois
$3.89M
Commonwealth Equity Services
290
Commonwealth Equity Services
Massachusetts
$3.87M
Nisa Investment Advisors
291
Nisa Investment Advisors
Missouri
$3.84M
Pacer Advisors
292
Pacer Advisors
Pennsylvania
$3.81M
CCIA
293
Campbell & Co Investment Adviser
Maryland
$3.77M
JSSH
294
J. Safra Sarasin Holding
$3.63M
MAM
295
Martingale Asset Management
Massachusetts
$3.63M
Capstone Investment Advisors
296
Capstone Investment Advisors
New York
$3.55M
KI
297
Keystone Investors
Singapore
$3.53M
LSERS
298
Louisiana State Employees Retirement System
Louisiana
$3.5M
VAS
299
Vestmark Advisory Solutions
Massachusetts
$3.49M
Walleye Trading
300
Walleye Trading
New York
$3.44M