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Alnylam Pharmaceuticals

833 hedge funds and large institutions have $51.6B invested in Alnylam Pharmaceuticals in 2025 Q4 according to their latest regulatory filings, with 160 funds opening new positions, 284 increasing their positions, 290 reducing their positions, and 115 closing their positions.

New
Increased
Maintained
Reduced
Closed

more call options, than puts

Call options by funds: $ | Put options by funds: $

more first-time investments, than exits

New positions opened: | Existing positions closed:

more funds holding

Funds holding:

less ownership

Funds ownership:

2% less repeat investments, than reductions

Existing positions increased: 284 | Existing positions reduced: 290

13% less capital invested

Capital invested by funds: $59.2B → $51.6B (-$7.56B)

69% less funds holding in top 10

Funds holding in top 10: 134 (-9)

Holders
833
Holders Change
Holders Change %
% of All Funds
Holding in Top 10
4
Holding in Top 10 Change
Holding in Top 10 Change %
% of All Funds
New
Increased
Reduced
Closed
Calls
$760M
Puts
$448M
Net Calls
Net Calls Change

Top Buyers

1 +$303M
2 +$220M
3 +$158M
4
UBS Group
UBS Group
Switzerland
+$149M
5
D.E. Shaw & Co
D.E. Shaw & Co
New York
+$108M

Top Sellers

1 -$635M
2 -$383M
3 -$360M
4
Jane Street
Jane Street
New York
-$287M
5
Macquarie Group
Macquarie Group
Australia
-$276M
Name Holding Trade Value Shares
Change
Change in
Stake
AV
276
ASR Vermogensbeheer
Netherlands
$4.38M
CWM
277
CIBC World Markets
New York
$4.36M
AB
278
Amalgamated Bank
New York
$4.25M
CB
279
Commerce Bank
Missouri
$4.19M
SAM
280
Silvercrest Asset Management
New York
$4.14M
ACM
281
Atika Capital Management
New York
$4.11M
HFM
282
Harvest Fund Management
China
$4.1M
HCS
283
Himension Capital (Singapore)
Singapore
$4.05M
Lazard Asset Management
284
Lazard Asset Management
New York
$4.04M
OSAM
285
O'Shaughnessy Asset Management
Connecticut
$3.95M
AC
286
Allstate Corporation
Illinois
$3.91M
ERSOT
287
Employees Retirement System of Texas
Texas
$3.89M
William Blair & Company
288
William Blair & Company
Illinois
$3.89M
Commonwealth Equity Services
289
Commonwealth Equity Services
Massachusetts
$3.87M
Nisa Investment Advisors
290
Nisa Investment Advisors
Missouri
$3.84M
Pacer Advisors
291
Pacer Advisors
Pennsylvania
$3.81M
CCIA
292
Campbell & Co Investment Adviser
Maryland
$3.77M
JSSH
293
J. Safra Sarasin Holding
$3.63M
MAM
294
Martingale Asset Management
Massachusetts
$3.63M
Capstone Investment Advisors
295
Capstone Investment Advisors
New York
$3.55M
KI
296
Keystone Investors
Singapore
$3.53M
LSERS
297
Louisiana State Employees Retirement System
Louisiana
$3.5M
VAS
298
Vestmark Advisory Solutions
Massachusetts
$3.49M
Walleye Trading
299
Walleye Trading
New York
$3.44M
TFA
300
Transamerica Financial Advisors
Florida
$3.42M